Search results for "Lung"
showing 10 items of 2389 documents
Measurement of the chi(b) (3 P) mass and of the relative rate of chi(b1) (1 P) and chi(b2) (1 P) production
2014
The production of $\chi_b$ mesons in proton-proton collisions is studied using a data sample collected by the LHCb detector, at centre-of-mass energies of $\sqrt{s}=7$ and $8$ TeV and corresponding to an integrated luminosity of 3.0 fb$^{-1}$. The $\chi_b$ mesons are identified through their decays to $\Upsilon(1S)\gamma$ and $\Upsilon(2S)\gamma$ using photons that converted to $e^+e^-$ pairs in the detector. The $\chi_b(3P)$ meson mass, and the relative prompt production rate of $\chi_{b1}(1P)$ and $\chi_{b2}(1P)$ mesons as a function of the $\Upsilon(1S)$ transverse momentum in the $\chi_b$ rapidity range 2.0< $y$<4.5, are measured. Assuming a mass splitting between the $\chi_{b1}(3P)$ an…
Characterization of the shape-staggering effect in mercury nuclei
2018
In rare cases, the removal of a single proton (Z) or neutron (N) from an atomic nucleus leads to a dramatic shape change. These instances are crucial for understanding the components of the nuclear interactions that drive deformation. The mercury isotopes (Z = 80) are a striking example1,2: their close neighbours, the lead isotopes (Z = 82), are spherical and steadily shrink with decreasing N. The even-mass (A = N + Z) mercury isotopes follow this trend. The odd-mass mercury isotopes 181,183,185Hg, however, exhibit noticeably larger charge radii. Due to the experimental difficulties of probing extremely neutron-deficient systems, and the computational complexity of modelling such heavy nucl…
A charge plunger device to measure the lifetimes of excited nuclear states where transitions are dominated by internal conversion
2020
A charge plunger device has been commissioned based on the DPUNS plunger (Taylor et al., 2013) using the in-flight mass separator MARA at the University of Jyväskylä. The 152Sm(32S,4n)180Pt reaction was used to populate excited states in 180Pt. A lifetime measurement of the 21+ state was performed by applying the charge plunger technique, which relies on the detection of the charge state-distribution of recoils rather than the detection of the emitted γ rays. This state was a good candidate to test the charge plunger technique as it has a known lifetime and depopulates through a converted transition that competes strongly with γ-ray emission. The lifetime of the 21+ state was measured to be…
First measurement of the charge asymmetry in beauty-quark pair production.
2014
The difference in the angular distributions between beauty quarks and antiquarks, referred to as the charge asymmetry, is measured for the first time in b[bar over b] pair production at a hadron collider. The data used correspond to an integrated luminosity of 1.0 fb[superscript −1] collected at 7 TeV center-of-mass energy in proton-proton collisions with the LHCb detector. The measurement is performed in three regions of the invariant mass of the b[bar over b] system. The results obtained are A[b[bar over b] over C](40 105 GeV/c[superscript 2]) = 1.6 ± 1.7 ± 0.6%, where A[b[bar over b] over C] is defined as the asymmetry in the difference in rapidity between jets formed from the beauty q…
Billion-Fold Enhancement in Sensitivity of Nuclear Magnetic Resonance Spectroscopy for Magnesium Ions in Solution
2014
Beta-nuclear magnetic resonance (NMR) spectroscopy is highly sensitive compared to conventional NMR spectroscopy, and may be applied for several elements across the periodic table. Beta-NMR has previously been successfully applied in the fields of nuclear and solid-state physics. In this work, beta-NMR is applied, for the first time, to record an NMR spectrum for a species in solution. 31Mg b-NMR spectra are measured for as few as 10^7 magnesium ions in ionic liquid (EMIM-Ac) within minutes, as a prototypical test case. Resonances are observed at 3882.9 and 3887.2 kHz in an external field of 0.3 T. The key achievement of the current work is to demonstrate that beta-NMR is applicable for the…
MR imaging of the lungs with hyperpolarized helium-3 gas transported by air.
2002
Hyperpolarized noble gas MRI shows promise in the functional imaging of the pulmonary air spaces. The production of hyperpolarized (HP) gas requires specialized laser optical pumping apparatus, which is not likely to be home built in the majority of clinical MRI radiology centres. There are two routes through which HP gas will be made available to hospitals for clinical use: either the apparatus will be installed locally at a considerable expense to the centre, or a central facility will produce the gas and then deliver it to remote MRI sites as and when required. In this study, the feasibility of transporting large quantities of HP gas for in vivo MR imaging from a remote production facili…
Study of intrinsic energy dependence of α-alanine and dose intercomparison with ESR and ISE techniques
1993
Abstract The intrinsic energy behavior of the radiation chemical yields G(R·) and G(NH3) which determine the dose response for the alanine/ESR and alanine/Ion-Selective Electrode (ISE) system, is an important characteristic for the consistent use in different radiation environments. Therefore, the response of ISS and Gent α-alanine dosimeters in the dose range 0.1 to 700 kGy was examined with 60Co, bremsstrahlung and electron beam radiation. Bremsstrahlung beams with end point energy between 5 and 12 MeV and electron beams with mean energy at the effective point of measurement between 4 and 25 MeV were used. Analysis of the 60Co calibration results shows that there are no significant differ…
Entrectinib: a potent new TRK, ROS1, and ALK inhibitor
2015
Abstract: Introduction: Receptor tyrosine kinases (RTKs) and their signaling pathways, control normal cellular processes; however, their deregulation play important roles in malignant transformation. In advanced non-small cell lung cancer (NSCLC), the recognition of oncogenic activation of specific RTKs, has led to the development of molecularly targeted agents that only benefit roughly 20% of patients. Entrectinib is a pan-TRK, ROS1 and ALK inhibitor that has shown potent anti-neoplastic activity and tolerability in various neoplastic conditions, particularly NSCLC. Areas covered: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-cl…
Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo
2001
5-(-{2-[4-(2-[18F]Fluoroethoxy)-phenyl]-l-methyl-ethylamino}-l-hydroxy-ethyl)-benzene-1, 3-diol ([18F]fluoroethylfenoterol) was synthesised from 4-(2-{benzyl-[2-(3,5-bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-amino}-propyl)-phenol using 2-[18F]fluoroethyltosylate (92% RCY) followed by reductive cleavage of the benzyl protecting groups. Preliminary in vitro tests showed [19F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself.
Amazing IL-9: revealing a new function for an “old” cytokine
2012
Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with…