Search results for "M1"
showing 10 items of 837 documents
Differential function of the phosphoglucomutase isozymes PGM1 and PGM2
1979
A total of 13 metabolites thought to be possibly inhibitory were tested for their influence on PGM isozyme activities, each at several different concentrations. The analysis of statistical significance was based on enzyme activities obtained by densitometric measurements of starch gels. Five of the substances were found to inhibit PGM activity, three of which definitely and a further one probably led to a significantly stronger inhibition of the isozymes of the PGM2 locus than of PGM1 isozymes. They are (1) fructose-1,6-diphosphate, (2) adenosine triphosphate, (3) citrate, and (4) possibly 2,3-diphosphoglycerate. Thus, PGM1 isozymes proved to function better in hard or perhaps marginal meta…
Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
2019
Muscarinic acetylcholine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [45]) are GPCRs of the Class A, rhodopsin-like family where the endogenous agonist is acetylcholine. In addition to the agents listed in the table, AC-42, its structural analogues AC-260584 and 77-LH-28-1, N-desmethylclozapine, TBPB and LuAE51090 have been described as functionally selective agonists of the M1 receptor subtype via binding in a mode distinct from that utilized by non-selective agonists [243, 242, 253, 155, 154, 181, 137, 11, 230]. There are two pharmacologically characterised allosteric sites on muscarinic receptors, one defined by it binding gallami…
Phorbol Esters and Muscarinic Receptor Agonists Activate Phospholipase D in Heart and Brain
1991
Phospholipase D (PLD) hydrolyzes phosphatidylcholine and thereby seems to play a key role in a novel pathway of signal transduction. PLD activity in rat hippocampal slices and atria of rat, guinea pig and chicken hearts was determined by measuring the catalytic products choline (Ch), phosphatidic acid (PA) and, in the presence of a primary alcohol, phosphatidylpropanol or phosphatidylethanol. It was found that the PLD activity was high, even under resting conditions, in both tissues, especially in the hippocampus, and that the enzyme activity could be enhanced by activation of protein kinase C and by muscarinic receptor stimulation.
Oxidative Stress and Cognitive Alterations Induced by Cancer Chemotherapy Drugs: A Scoping Review
2021
Cognitive impairment is one of the most deleterious effects of chemotherapy treatment in cancer patients, and this problem sometimes remains even after chemotherapy ends. Common classes of chemotherapy-based regimens such as anthracyclines, taxanes, and platinum derivatives can induce both oxidative stress in the blood and in the brain, and these effects can be reproduced in neuronal and glia cell cultures. In rodent models, both the acute and repeated administration of doxorubicin or adriamycin (anthracyclines) or cisplatin impairs cognitive functions, as shown by their diminished performance in different learning and memory behavioural tasks. Administration of compounds with strong antiox…
Automatisation des tableaux de bord et cohérence du contrôle de gestion : à propos de deux cas
2007
Cet article presente les resultats d’une enquete exploratoire dont l’objet est l’etude des rapports entre l’automatisation des tableaux de bord et la coherence du controle de gestion. A partir de deux cas juges exemplaires, celui d’une entreprise industrielle et celui d’une banque, nous etudions cette relation sous l’angle du partage des representations et de la coherence des comportements. Il en ressort que l’augmentation de la formalisation ne cree pas davantage de rigidite mais produit au contraire plus de dynamique ou de continuite et de permanence. Cependant, les resultats montrent aussi la limite d’une gestion automatique de la coherence dans la mesure ou les informations necessaires …
Preservation in Disaster Situations: a case study of the Valvilla Wool Mill Museum, Finland
2013
This article discusses the role of documentation and rescue planning in minimizing collection damages in disaster situations. The topic is surveyed through a case study of a fire that occurred in 2003 at the Valvilla Wool Mill museum in Hyvinkää, in Southern Finland. This incident caused significant damage to the authenticity and integrity of the museum’s archival collection. Both the fire and the extinguishing of the fire caused severe damage to items in the archival collection. Deterioration continued during aftercare, causing serious secondary collection damage because the methods of the first aid and aftercare were spontaneously planned and applied. By using the Valvilla Wool Mill museu…
CORPORATE SOCIAL RESPONSABILITY IN THE CURRENT GLOBAL ECONOMIC CONTEXT
2012
In the current economic context, the social issue has become a major preoccupation for the current activity of the organizations that aim to create performance. This is because the modern organization is evaluated also from the point of view of its contribution to the social life of the community it belongs to. As Sophocles said “all benefactors think a little bit also about themselves”. Nowadays, managers not only do they have to lead the activities of the economic organizations in a profitable way, but also have to be responsible for the impact of these activities. Therefore, when confronted to the numerous opportunities and dangers, current companies and managers must find economically, …
L'articulation des usages diagnostique et interactif d'un seul et même système de contrôle de gestion : le cas d'un système d'indicateurs environneme…
2013
With the conceptual framework of control levers of Simons (1995), this article shows how to coordinate diagnostic and interactive uses of the same "management control system" (in this case a system of environmental indicators) for the deployment and the emergence of new strategies. In contrast to the literature, we propose an articulation "in parallel" of levers of control as alternative to sliding levers of control. These results are obtained from a case study in a French wine and spirits subject to large strategic environmental uncertainties.
Atmosfēras piesārņojuma personificētais monitorings
2020
Bakalaura darbā “Atmosfēras piesārņojuma personificētais monitorings” apkopota zinātniskā literatūra par atmosfēras piesārņojumu, avotiem, ietekmi uz veselību, raksturota situācija Latvijā. Darba praktiskā daļā veikti cieto daļiņu (PM10, PM2,5), slāpekļa dioksīda un gaistošo organisko savienojumu mērījumi dažādos selektīvi izvēlētos maršrutos laika periodā no 20.02.2020. līdz 29.04.2020. realizējot personificēto monitoringu. Mērījumi veikti izmantojot ar gaisa kvalitātes sensoriem aprīkotu iekārtu – individuālo dozimetru. Iegūtie mērījumi sistematizēti un apstrādāti, lai novērtētu indivīdam uzņemto piesārņojuma dozu.
The Analyses of the Teacher’s Activities Facing with Efficiency
2008
The element of education has here a very important role not only regarding the aspect of quality of the act but in integrating the need of quality in the national culture. The individual’s conception has to assimilate the conviction that the welfare can not exist without a responsible and quality labor. Starting form this mission, it becomes obvious that the entire university’s activity should be oriented towards the institution’s competitiveness growth both at a national level and at the international level through: the quality of the offer and the result of the activity, a good management, a financial politic adequate to the rational use of the resources and of drawing new resources, to s…