Search results for "M2"
showing 10 items of 256 documents
Development of a Novel Object Detection System Based on Synthetic Data Generated from Unreal Game Engine
2022
This paper presents a novel approach to training a real-world object detection system based on synthetic data utilizing state-of-the-art technologies. Training an object detection system can be challenging and time-consuming as machine learning requires substantial volumes of training data with associated metadata. Synthetic data can solve this by providing unlimited desired training data with automatic generation. However, the main challenge is creating a balanced dataset that closes the reality gap and generalizes well when deployed in the real world. A state-of-the-art game engine, Unreal Engine 4, was used to approach the challenge of generating a photorealistic dataset for deep learnin…
Chapter 17 Muscarinic receptors and cell signalling
1996
Publisher Summary Cells have developed signal transduction mechanisms in order to communicate with the cell exterior. Acetylcholine as an external signal is recognized by nicotinic and muscarinic receptors. This chapter presents various muscarinic receptors belonging to the superfamily of G protein-coupled receptors consisting of seven transmembrane (TM) helices tightly packed in a ring-like structure and arranged in a counter-clockwise fashion. Agonist binding leads to a conformational change of the receptor, thereby activating associated G proteins. Muscarinic stimulation of G proteins leads to the activation or inhibition of ion channels, such as K + and Ca 2+ channels, the activation of…
The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA2+-fil…
2015
Abstract Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca2+ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6. Here we compared the structure, subcellular localization, tissue expression and the effect on the cellular Ca2+ homeostasis of all family members side by side. We found that all TMBIM proteins possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 and its bacterial homologue BsYetJ. TMBIM1-3 and TMBIM4-6 represent two phylogenetically distinct groups that are localized in the Go…
THE SHAPLEY-SOLIDARITY VALUE FOR GAMES WITH A COALITION STRUCTURE
2013
A value for games with a coalition structure is introduced, where the rules guiding cooperation among the members of the same coalition are different from the interaction rules among coalitions. In particular, players inside a coalition exhibit a greater degree of solidarity than they are willing to use with players outside their coalition. The Shapley value is therefore used to compute the aggregate payoffs for the coalitions, and the solidarity value to obtain the payoffs for the players inside each coalition.
Mutations in the β-tropomyosin (TPM2) gene – a rare cause of nemaline myopathy
2002
Nemaline myopathy is a clinically and genetically heterogeneous muscle disorder. In the nebulin gene we have detected a number of autosomal recessive mutations. Both autosomal dominant and recessive mutations have been detected in the genes for alpha -actin and alpha -tropomyosin 3. A recessive mutation causing nemaline myopathy among the Old Order Amish has recently been identified in the gene for slow skeletal muscle troponin T. As linkage studies had shown that at least one further gene exists for nemaline myopathy, we investigated another tropomyosin gene expressed in skeletal muscle, the beta -tropomyosin 2 gene. Screening 66 unrelated patients, using single strand conformation polymor…
Heterodimerization of Two Pathological Mutants Enhances the Activity of Human Phosphomannomutase2
2015
The most frequent disorder of glycosylation is due to mutations in the gene encoding phosphomannomutase2 (PMM2-CDG). For this disease, which is autosomal and recessive, there is no cure at present. Most patients are composite heterozygous and carry one allele encoding an inactive mutant, R141H, and one encoding a hypomorphic mutant. Phosphomannomutase2 is a dimer. We reproduced composite heterozygosity in vitro by mixing R141H either with the wild type protein or the most common hypomorphic mutant F119L and compared the quaternary structure, the activity and the stability of the heterodimeric enzymes. We demonstrated that the activity of R141H/F119L heterodimers in vitro, which reproduces t…
Languages associated with saturated formations of groups
2013
International audience; In a previous paper, the authors have shown that Eilenberg's variety theorem can be extended to more general structures, called formations. In this paper, we give a general method to describe the languages corresponding to saturated formations of groups, which are widely studied in group theory. We recover in this way a number of known results about the languages corresponding to the classes of nilpotent groups, soluble groups and supersoluble groups. Our method also applies to new examples, like the class of groups having a Sylow tower.; Dans un article précédent, les auteurs avaient montré comment étendre le théorème des variétés d'Eilenberg à des structures plus g…
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Regularity and h-polynomials of toric ideals of graphs
2020
For all integers 4 ≤ r ≤ d 4 \leq r \leq d , we show that there exists a finite simple graph G = G r , d G= G_{r,d} with toric ideal I G ⊂ R I_G \subset R such that R / I G R/I_G has (Castelnuovo–Mumford) regularity r r and h h -polynomial of degree d d . To achieve this goal, we identify a family of graphs such that the graded Betti numbers of the associated toric ideal agree with its initial ideal, and, furthermore, that this initial ideal has linear quotients. As a corollary, we can recover a result of Hibi, Higashitani, Kimura, and O’Keefe that compares the depth and dimension of toric ideals of graphs.
Soluble E-Selectin Enhances Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Human Tumor Cell Lines
1998
E-selectin mediates neovascularization via its soluble form, while its membrane-bound form initiates binding of tumor cells to vascular endothelium. Therefore, it was studied whether soluble E-selectin regulates further adhesion molecules on tumor cells. In tumor cells but not in related nonmalignant cells, intercellular adhesion molecule (ICAM)-1 expression was strikingly increased from 5 to 68% positive cells by in vitro inoculation of a recombinant E-selectin-IgG1 within 24 h, as analyzed by flow cytometry. The absence of changes in the expression of vascular cell adhesion molecule, integrin ligands (CD11a, CD18, integrin alpha 4), and sialyl-Lewis X indicates a specific effect of solubl…