Search results for "MIME"
showing 10 items of 311 documents
Behavioural and pharmacological characterization of a novel cannabimimetic adamantane-derived indole, APICA, in C57BL/6J mice
2015
The novel adamantane derivative APICA (N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide) was recently identified as a cannabimimetic indole of abuse (1, 2). Despite its novel structure, APICA recalls cannabimimetic indoles, such as representative member JWH-018. The emerging abuse problem, together with the paucity of information about the bioactivity of APICA (3) emphasize the need for further evaluation of the in vivo pharmacology of this novel indole-derived compound. In the present study, the effects of APICA (0 - 1 - 3 mg/Kg, i.p.) were tested in C57BL/6J mice, in a battery of tests that are sensitive to the effects of psychoactive cannabinoids, including body temperature; locomotor a…
Adaptive Materials Research for Architecture
2018
The volume "Adaptive Materials Research for Architecture" is a Special Issue of the journal "Advanced Material Research". The goal of this volume is to spread knowledge on studies, analyses and results of scientific research carried out from academics, researchers, and scientists regarding the soundest issues related to smart materials, innovative technologies and ongoing researches in the field of adaptive materials in past and current architectural practice.
1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs.
2021
[Image: see text] 1,5-Disubstituted 1,2,3-triazoles (1,5-Tz) are considered bioisosteres of cis-amide bonds. However, their use for enhancing the pharmacological properties of peptides or proteins is not yet well established. Aiming to illustrate their utility, we chose the peptide conjugate [Nle(15)]MG11 (DOTA-dGlu-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH(2)) as a model compound since it is known that the cholecystokinin-2 receptor (CCK2R) is able to accommodate turn conformations. Analogs of [Nle(15)]MG11 incorporating 1,5-Tz in the backbone were synthesized and radiolabeled with lutetium-177, and their pharmacological properties (cell internalization, receptor binding affinity and specificity, pla…
Manganese(II) complexes of scorpiand-like azamacrocycles as MnSOD mimics.
2011
Mn(II) complexes of scorpiand-type azamacrocycles constituted by a tretrazapyridinophane core appended with an ethylamino tail including 2- or 4-quinoline functionalities show very appealing in vitro SOD activity. The observed behaviour is related to structural and electrochemical parameters.
Power-Laws hereditariness of biomimetic ceramics for cranioplasty neurosurgery
2019
Abstract We discuss the hereditary behavior of hydroxyapatite-based composites used for cranioplasty surgery in the context of material isotropy. We classify mixtures of collagen and hydroxiapatite composites as biomimetic ceramic composites with hereditary properties modeled by fractional-order calculus. We assume isotropy of the biomimetic ceramic is assumed and provide thermodynamic of restrictions for the material parameters. We exploit the proposed formulation of the fractional-order isotropic hereditariness further by means of a novel mechanical hierarchy corresponding exactly to the three-dimensional fractional-order constitutive model introduced.
Synthesis of calcium carbonate biological materials: how many proteins are needed?
2013
In Nature, calcium carbonate biomineralizations are the most abundant mineralized structures of biological origin. Because many exhibit remarkable characteristics, several attempts have been made to use them as substitution materials for bone reconstruction or as models for generating biomimetic composites that exhibit tailored properties. CaCO3biomineralizations contain small amounts of amalgamate of proteins and polysaccharides that are secreted during the calcification process. They contribute to control the morphology of the crystallites and to spatially organize them in well-defined microstructures. These macromolecules, collectively defined as the skeletal matrix, have been the focus …
Gene therapy with growth factors for periodontal tissue engineering : a review
2011
The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. A challenge faced by periodontal therapy is the predictable regeneration of periodontal tissues lost as a consequence of disease. Growth factors are critical to the development, maturation, maintenance and repair of oral tissues as they establish an extra-cellular environment that is conducive to cell and tissue growth. Tissue engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microen…
Exploiting Imperfections in Perception-Action Learning
2019
In this paper a some examples of simulations and experiments performed in the last few years in the field of bio-inspired robotics are reviewed and revisited, deepening their characteristics and emphasising the role of imperfections that could be the main actors guiding their success in real environment. Our cases of study rely on both geetic and behavioral experiments on the fruit fly, from which models, simulations and robotic experiments were performed.
Development of peptidomimetic boronates as proteasome inhibitors.
2013
Abstract Proteasome inhibition has emerged over the past decade as an effective therapeutic approach for the treatment of hematologic malignancies. It is a multicatalytic complex, whose proteolytic activity relies in three types of subunits: chymotrypsin-like (β5), trypsin-like (β2) and caspase-like (β1). Most important for the development of effective antitumor agents is the inhibition of the β5 subunits. In this context, the dipeptide boronate bortezomib (Velcade ® ) represents the first proteasome inhibitor approved by the FDA and the lead compound in drug discovery. This paper describes the synthesis and biological evaluation of a series of conformationally constrained pseudopeptide bor…
Los avatares de un cuadro: arte y literatura en El sueño de Venecia de Paloma Díaz-Mas y El velázquez de París de Carmen Boullosa
2008
En El sueño de Venecia de Paloma Díaz-Mas y en El velázquez de París de Carmen Boullosa, el protagonismo recae en un cuadro y los avatares sufridos por el mismo a lo largo de la historia. El propósito de este estudio es analizar la manera en que el rastreo de la historia de estos cuadros en ambas novelas genera reflexiones de índole pictórica y literaria sobre la naturaleza del arte, el proceso de creación, el carácter de la recepción e interpretación artísticas y el papel de la memoria y el arte tanto pictórico como literario en la recuperación o invención del pasado.