Search results for "Mace"
showing 10 items of 4713 documents
Architecture in iron in the city of XIX century Roof structures of theatres and covered markets in Palermo
2016
In post-unification Palermo, components manufactured abroad were usually used for complementary iron structures (greenhouses and skylights, projecting roofs, staircases…), whereas, for more demanding works, more weight was given to the contribution of producers with experience gained in the field of metal construction. Analysis is here carried out on the works of greatest importance, from the roofs of the two major theatres to the roofing of food market structures; the finest technicians were employed and a critical debate was triggered in the city with regard to formal, static and building aspects.
Strategies, Technologies and Novel Components for the Architectural Integration of Photovoltaics
2015
La ricerca riguarda l'integrazione architettonica del fotovoltaico (FV) per il retrofit energetico del patrimonio edilizio esistente e la costruzione di edifici a energia zero (ZEB). L'obiettivo è lo studio e la successiva definizione di strategie, tecnologie e componenti innovativi per l'involucro edilizio che integrino il fotovoltaico, con particolare attenzione verso le tecnologie fotovoltaiche di nuova generazione. Il lavoro si concentra anche sull'ottimizzazione energetica e sull'analisi delle prestazioni di un componente innovativo per il BIPV (Building Integrated Photovoltaics, letteralmente fotovoltaico integrato negli edifici) utile alla costruzione di involucri edilizi sostenibili…
The assessment of the reliability of an innovative 3rd generation solar cell integrated with “thermal belt” glass block
2017
Glass block is a building product widely used for the construction of translucent building façades and roofs. The need to adapt the product to the regulations in the field of energy saving and environmental sustainability has led to the design of innovative configurations, through the integration of different sub-components. These ones are able to improve its energy performance by means of the integration of a“thermal belt”, cold glued to the glass shells, which constitute the traditional glass block, and 3rd generation solar cells. This paper reports the first results of the experimental program designed to assess some durability components: inherent and critical reliability. <div id="g…
Sorafenib in Mice – A Pharmacokinetic Study
2015
Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fide…
Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery
2020
Transcutaneous immunization (TCI) via needle-free and non-invasive drug delivery systems is a promising approach for overcoming the current limitations of conventional parenteral vaccination methods. The targeted access to professional antigen-presenting cell (APC) populations within the skin, such as Langerhans cells (LCs), various dermal dendritic cells (dDCs), macrophages, and others makes the skin an ideal vaccination site to specifically shape immune responses as required. The stratum corneum (SC) of the skin is the main penetration barrier that needs to be overcome by the vaccine components in a coordinated way to achieve optimal access to dermal APC populations that induce priming of…
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R
2021
Euphorbia species have a large spectrum of traditional medicinal uses. We tested the biological activities of the essential oil (EO) of Euphorbia intisy Drake in an acquired multidrug resistance leukemia model to assess whether the EO obtained by hydrodistillation of stems was able to reverse the resistant phenotype. HL-60R cell lines are characterized by the overexpression of P-glycoprotein (P-gp), inhibitors of apoptosis proteins (IAPs) and constitutive expression of NF-κB. EO chemical composition was determined by GC/MS analysis
Spectral characteristics of 5-hydroxymethylfurfural as a related substance in medicinal products containing glucose
2019
Objectives: To study 5-hydroxymethylfurfural (5-HMF) spectral characteristics aiming at their future application in analytical procedures and their validation for the determination of 5-HMF in liquid products containing glucose after sterilization.Method: Direct spectrophotometric method for the determination of 5-HMF using the molar absorption coefficient at the absorption maximum (284 nm).Results and discussion: aqueous 5-HMF solutions have strong absorption in the ultraviolet range below 310 nm and give two absorption maxima at wavelengths of 229–230 nm and 284 nm. An excellent linear relationship between absorbance and 5-HMF concentration was observed in the concentration range of 2.0–1…
Analytical Research Based on the Use of Low Cost Instrumentation
2019
Erratum: Mangas-Sanjuán, V.; et al. Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the De…
2020
Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a reference ointment containing calcipotriol and betamethasone (Daivobet 50 µg/0.5 mg/g) in order to define the acceptance range that allows concluding equivalence between these batches. Being batches of the same reference product, they are expected to be clinically equivalent and possess similar microstructure. The 90% confidence intervals for the test/reference ratio of these physical parameters …
Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine, a new ring system as potential COX inhibitor
2012
Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.