Search results for "Mace"

A modelistic approach showing the importance of the stagnant aqueous layers in in vitro diffusion studies, and in vitro-in vivo correlations

1991

Abstract The present study deals with the role of the aqueous diffusion layers on the in vitro penetration of xenobiotics across artificial lipoidal membranes, and their ability to reproduce biophysical absorption models when in vivo results are to be simulated from the in vitro tests. The aqueous boundary layers which are invariably formed on artificial lipoidal membranes can be optionally preserved or disrupted, according to the type of absorption site which should be simulated, a condition which could reasonably lead to a better correspondence between in vitro and in vivo results; in practice, disruption of water layers can be easily achieved by a synthetic surfactant solution at its cri…

Antivirale Wirkstoffe, 20. Mitt. 4,6-Dialkylierte 2-Benzylthiopyrimidine

1981

Aus der Kondensation von Benzylisothioharnstoff (1) mit den β-Diketonen 2a–c gehen die 2-Benzylthiopyrimidine 3a–c hervor. Wird die Reaktion 1+2b jedoch in 30proz. wasr. Kaliumcarbonat-Losung/Ethanol/Ether durchgefuhrt, so tritt unter Ethanolyse Bildung von 2-Ethoxy-4,6-diethylpyrimidin (4) ein. 2-Benzylthio-4-ethyl-6-(trifluormethyl)pyrimidin ubt Hemmwirkung gegen Influenza A-Virus aus. Antiviral Agents, XX: 4,6-Dialkylated 2-Benzylthiopyrimidines Condensations of benzylisothiourea (1) with the β-diketones 2a–c yield the 4,6-dialkylated 2-benzylthiopyrimidines 3a–c. However, in 30% aqueous potassium carbonate solution/ethanol/ether, the reaction 1+2b proceeds by ethanolysis to form 2-ethox…

Water-Soluble Polysaccharides from Ephedra alata Stems: Structural Characterization, Functional Properties, and Antioxidant Activity

2020

In this study, the physicochemical characterization, functional properties, and antioxidant activity of polysaccharides extracted from Ephedra alata (EAP) were investigated. EAP were extracted in water during 3 h with a liquid/solid ratio of 5 in a water bath at 90 &deg

SINGLE-PEAK RESOLUTION CRITERIA FOR OPTIMIZATION OF MOBILE PHASE COMPOSITION IN LIQUID CHROMATOGRAPHY

2001

Three criteria that evaluate the single peak resolution (peak purity) in chromatography, the free height fraction, free area fraction, and valley ratio, are examined. The main advantages of these criteria against other criteria based on peak pair separation, are that the measurements are not affected by the identity of neighboring peaks and are normalized, which make them very intuitive. The methodology is illustrated through the isocratic separation of mixtures of several sulphonamides (sulphacetamide, sulphadiazine, sulphadimethoxine, sulphaguanidine, sulphamerazine, sulphamethazine, sulphamethoxazole, sulphamethizole, sulphamonomethoxine, sulphanilamide, sulphapyridine, sulphaquinoxaline…

2019

Structural changes of glycolic acid (GA) complex with nitrogen induced by selective overtone excitation of the νOH mode were followed in argon matrices using FTIR spectroscopy. For the most stable SSC1 complex present in different trapping sites directly upon deposition site, selective changes in the νOH region were achieved upon near-infrared irradiation. Simultaneously, new conformers of the GA…N2 complex were formed, giving rise to several sets of bands in the νOH and νC=O regions of the spectra. Both position and intensity of new absorptions appeared to be highly sensitive on the wavelength of radiation used, as well as on the annealing of the matrix. Based on theoretical calculations a…

Antibacterial and antifungal activities of Otanthus maritimus (L.) Hoffmanns.Link essential oil from Sicily.

2013

The chemical composition of the essential oil obtained from the flowers of Otanthus maritimus L., a perennial plant growing wild in maritime sands in the Mediterranean region, was investigated by GC and GC-MS analyses. Totally 66 were identified. The oil was dominated by the high content of monoterpene compounds, especially oxygenated monoterpenes which accounted for 73.1%. The most abundant components were yomogi alcohol (20.8%), camphor (15.8%), artemisyl acetate (15.3%) and artemisia alcohol (13.7%). The oil was tested against two Gram (+) and six Gram (-) bacterial strains, both American Type Culture Collection standard strains and clinically isolated (CI), one potentially pathogenic ye…

Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long-term pulmonary function in patients treated with recombinant human N-acet…

2010

Pulmonary function is impaired in untreated mucopolysaccharidosis type VI (MPS VI). Pulmonary function was studied in patients during long-term enzyme replacement therapy (ERT) with recombinant human arylsulfatase B (rhASB; rhN-acetylgalactosamine 4-sulfatase). Pulmonary function tests prior to and for up to 240 weeks of weekly infusions of rhASB at 1 mg/kg were completed in 56 patients during Phase 1/2, Phase 2, Phase 3 and Phase 3 Extension trials of rhASB and the Survey Study. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and, in a subset of patients, maximum voluntary ventilation (MVV), were analyzed as absolute volume in liters. FEV1 and FVC showed little change f…

Über das Vorkommen von Atropin in Sclerotinia minor Jagger und Corticium rolfsii Curzi

1960

Kardiovaskulārā riska izvērtējums ar FFR-CT metodi pacientiem ar perifēro artēriju oklizīvu slimību perioperatīvajā periodā

2018

Ievads. Perifēro artēriju okluzīva slimība (PAOS) ir aterosklerotiska saslimšana, kas raksturojas ar vienas vai vairāku perifēro artēriju stenozi vai oklūziju. Kopīgie riska faktori PAOS un koronāro artēriju slimībai (KAS) rezultējas ar to, ka pacientiem ar PAOS ir lielāka KAS incidence, kā arī risks jauniem koronāriem notikumiem. PAOS pacientu mirstība koronāro notikumu dēļ ir 6,6 reizes lielāka nekā pacientiem bez šīs slimības (Duran et al., 2010). Frakcionētās plūsmas rezerves aprēķināšana izmantojot datortomogrāfijas angiogrāfiju (FFRCT) ir metode, kas ļauj neinvazīvi izmeklēt vainagartērijas un diagnosticēt hemodinamiski nozīmīgas stenozes. Metodes un materiāli. PSKUS prospektīvā pētīj…

Holesterīna pazeminošo līdzekļu aprites datu analīze un pacientu aptaujas izvērtējums

2016

Paaugstināts holesterīna līmenis asinīs ir būtisks koronārās sirds slimības riska faktors, no tām mirstības rādītājs Latvijā ir trīs reizes augstāks nekā vidēji ES valstīs un augstākais Baltijas valstīs (SPKC, 2016). Maģistra darba mērķis ir analizēt informāciju no receptēm par holesterīna pazeminošo medikamentu apriti 2 gadu periodā un ar anketēšanas metodi analizēt pacientu aptaujas datus. Visbiežāk izrakstītā aktīvā viela gan pēc aprites (2013. g. - 57%; 2014. g. - 53%) gan pēc aptaujas (56%) datiem ir atorvastatīns. Otrs izrakstītākais ir rosuvastatīns. Farmaceitam ir svarīga loma sniedzot atbalstu pacientam ar veselību saistītos jautājumos: 19% respondentu farmaceits ir aicinājis pārba…