Search results for "Map"
showing 10 items of 3484 documents
Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity
2013
Jak/Tyk proteins have recently aroused as possible therapeutic targets for the treatment of psoriasis. In psoriasis, these proteins signal through STAT molecules including STAT3, and STAT3 expression and activation has been shown augmented in psoriatic lesions. Here, we characterized the expression of Jak/Tyk proteins in lesional compared with non-lesional psoriatic skin. Jak1, Jak2 mRNA and protein and Tyk2 mRNA appeared to be downregulated, whereas Jak3 mRNA expression was increased. Moreover, STAT3 expression and activation was examined in psoriasis. STAT3 is activated at two phosphorylation sites: Tyr705 and Ser727. Both phosphorylation sites were phosphorylated in lesional psoriatic sk…
A region on human chromosome 4 (q35.1→qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis
2005
Human papillomavirus (HPV) types 16 and 18 are known to play a major role in cervical carcinogenesis. Additional genetic alterations are required for the development and progression of cervical cancer. Previously, we showed that the introduction of an entire human chromosome 4 into HPV-immortalized cells by microcell-mediated chromosome transfer (MMCT) can induce senescence in cell hybrids. In the present study, we established eight new murine donor cell lines harboring different fragments of the human chromosome 4. These were tested for their ability to induce senescence by MMCT into HPV16-immortalized keratinocytes (HPK II) and cervical carcinoma cells (HeLa). By exclusion, we could ident…
Human kininogens interact with M protein, a bacterial surface protein and virulence determinant.
1995
Streptococcus pyogenes, the most significant streptococcal species in clinical medicine, expresses surface proteins with affinity for several human plasma proteins. Here we report that kininogens, the precursors to the vasoactive kinins, bind to the surface of S. pyogenes. M protein, a surface molecule and a major virulence factor-in these bacteria, occurs in > 80 different serotypes. Among 49 strains of S. pyogenes, all of different M serotypes, 41 bound radiolabelled kininogens, whereas 6 M protein-negative mutant strains showed no affinity. M protein of most serotypes bind fibrinogen, and among the 55 strains tested, binding of kininogens was closely correlated to fibrinogen bindi…
The case for strategic international alliances to harness nutritional genomics for public and personal health
2005
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need …
Design of an ICT Tool for Decision Making in Social and Health Policies
2015
The governance requires technical support regarding the complexity in deciding health policies to assist people who require long-term care. Long-term care policies require the use of ICT simulation tools that can provide policy makers with the option of going into a decision theatre and virtually knowing the consequences of different policies prior to finally determining the real policy to be adopted. In this sense, there is an absence of simulation tools for decision making about long-term care policies. In this chapter, the authors propose the foundations and guidelines of SSIMSOWELL, a new scalable, multiagent simulation tool that increases the prediction capacity of governance in the lo…
A geostatistical approach to map near-surface soil moisture through hyperspatial resolution thermal inertia.
2021
Thermal inertia has been applied to map soil water content exploiting remote sensing data in the short and long wave regions of the electromagnetic spectrum. Over the last years, optical and thermal cameras were sufficiently miniaturized to be loaded onboard of unmanned aerial systems (UASs), which provide unprecedented potentials to derive hyperspatial resolution thermal inertia for soil water content mapping. In this study, we apply a simplification of thermal inertia, the apparent thermal inertia (ATI), over pixels where underlying thermal inertia hypotheses are fulfilled (unshaded bare soil). Then, a kriging algorithm is used to spatialize the ATI to get a soil water content map. The pr…
Sisarusten hoidon järjestäminen kun perheeseen syntyy vauva
2016
TIIVISTELMÄ Huupponen Mari. 2016. Sisarusten hoidon järjestäminen kun perheeseen syntyy vauva. Varhaiskasvatustieteen pro gradu–tutkielma. Jyväskylän yliopisto. Varhaiskasvatuksen laitos. 70 sivua. Tässä tutkimuksessa perehdyin sisarusten hoidon järjestämiseen kun perheeseen syntyy vauva. Tutkimuksen tarkoituksena oli saada selville kuinka yleistä on viedä sisarus päivähoitoon ja mitkä syyt vaikuttavat päätökseen hoitopaikasta. Aiheeseen perehdyin lasten kasvu- ja toimintaympäristöjen kautta, jotka tässä tutkimuksessa ovat koti- ja päivähoitoympäristöt. Vanhemmuutta tarkastelin mm Rautiaisen (2001) vanhemmuuden roolikartan sekä erilaisten kasvatusilmapiirien (Alasuutari 2003; Ugaste 2005) k…
Calibrating the effective scattering albedo in the SMOS algorithm: some first results
2016
International audience; This study focuses on the calibration of the effective scattering albedo (ω) of vegetation in the soil moisture (SM) retrieval at L-Band. Currently, in the SMOS Level 2 and 3 algorithms, the value of ω is set to 0 for low vegetation and ∼ 0.06 – 0.08 for forests. Different parameterizations of vegetation (in terms of ω values) were tested in this study. The possibility of combining soil roughness and vegetation contributions as a single parameter (“combined” method) leads to an important simplification in the algorithm and was also evaluated here. Following these assumptions, retrieved values of SMOS SM were compared with SM data measured over many in situ sites worl…
Comparison of downscaling techniques for high resolution soil moisture mapping
2017
Soil moisture impacts exchanges of water, energy and carbon fluxes between the land surface and the atmosphere. Passive microwave remote sensing at L-band can capture spatial and temporal patterns of soil moisture in the landscape. Both ESA and NASA have launched L-band radiometers, in the form of the SMOS and SMAP satellites respectively, to monitor soil moisture globally, every 3-day at about 40 km resolution. However, their coarse scale restricts the range of applications. While SMAP included an L-band radar to downscale the radiometer soil moisture to 9 km, the radar failed after 3 months and this initial approach is not applicable to developing a consistent long term soil moisture prod…
Analyzing the impact of using the SRP (Simplified roughness parameterization) method on soil moisture retrieval over different regions of the globe
2015
International audience; This paper focuses on a new approach to account for soil roughness effects in the retrieval of soil moisture (SM) at L-band in the framework of the SMOS (Soil Moisture and Ocean Salinity) mission: the Simplified Roughness Parameterization (SRP). While the classical retrieval approach considers SM and τ nad (vegetation optical depth) as retrieved parameters, this approach is based on the retrieval of SM and the TR parameter combining τ nad and soil roughness (TR τ nad + Hr /2). Different roughness parameterizations were tested to find the best correlation (R), bias and unbiased RMSE (ubRMSE) when comparing homogeneous retrievals of SM and in situ SM measurements carri…