Search results for "Memory"

Suppressive effects of C3b on monocyte-dependent T cell proliferation.

1987

The effect of C3b treatment of human monocytes on secondary antigen-dependent T cell response was studied. When antigen-specific T cell blasts were cultivated together with C3b-treated monocytes the proliferative response was inhibited in a dose-dependent fashion. This suppressive effect was specific for C3b because heat-inactivated C3b or buffer alone had no influence on T cell proliferation. In part, this suppressive effect is mediated through a C3b-induced decreased expression of class II antigens on the surface of treated monocytes, but another suppressive mechanism exists because the C3b pretreatment of monocytes also led to an inhibition of the proliferative response in a class II ant…

T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

2015

International audience; T lymphocytes' ability to discriminate between structurally related antigens has been attributed to the unique signaling properties of the T cell receptor. However, recent studies have suggested that the output of this discrimination process is conditioned by environmental cues. Here, we demonstrate how the IL-2 cytokine, collectively generated by strongly activated T cell clones, can induce weaker T cell clones to proliferate. We identify the PI3K pathway as being critical for integrating the antigen and cytokine responses and for controlling cell-cycle entry. We build a hybrid stochastic/deterministic computational model that accounts for such signal synergism and …

Relative importance of taste, texture and flavour on consumers memory for custard desserts

2006

International audience

A Guide to Designing a Memory fMRI Paradigm for Pre-surgical Evaluation in Temporal Lobe Epilepsy

2020

There has been increasing interest in the clinical and experimental use of memory functional Magnetic Resonance Imaging (fMRI). The 2017 American Academy of Neurology practice guidelines on the use of pre-surgical cognitive fMRI suggests that verbal memory fMRI could be used to lateralize memory functions in people with Temporal Lobe Epilepsy (TLE) and should be used to predict post-operative verbal memory outcome. There are however technical and methodological considerations, to optimize both the sensitivity and specificity of this imaging modality. Below we discuss these constraints and suggest recommendations to consider when designing a memory fMRI paradigm.

Editorial: Activation, functions, and generation of immunological memory in γδ T lymphocytes: lessons from nonhuman primates

2014

T cells constitute an unconventional lymphocyte population with distinct functions complementary to those of CD4 and CD8 T cells. As such, they have both adaptive features, such as expression of the TCR, and innate-like functions reminiscent of NK cells, with whom they share extensive repertoires of activating and inhibitory receptors [1, 2]. Although most antigens recognized by murine T cells remain obscure, advances have been made in identifying ligands for human T cells. The majority of circulating human T lymphocytes expresses a TCR formed by the preferentially-paired V 9 and V 2 chains (here and thereafter, called V 9V 2 T cells). Instead of binding peptides associated with molecules b…

Empirical Autotuning of Two-level Parallel Linear Algebra Routines on Large cc-NUMA Systems

2012

In large cc-NUMA systems the efficient use of the different levels of the memory hierarchy is not an easy task, and the performance of multithreading implementations of the libraries decreases when the number of cores used increases, so producing an important lost of efficiency. To alleviate this problem, routines with multilevel parallelism can be developed by combining OpenMP and BLAS parallelism. In that way, higher performance can be achieved, but it is necessary to develop some autotuning technique for the appropriate selection of the number of threads to use at each level. The selection can be made through theoretical models of the execution time or some installation methodology. This…

2017

Moving and acting underwater within recreational or occupational activities requires intact executive functions, since they subserve higher cognitive functions such as successful self-regulation, coping with novel situations, and decision making; all of which could be influenced by nitrogen narcosis due to elevated partial pressure under water. However, specific executive functions that could provide a differentiated view on humans’ cognitive performance ability have not yet been systematically analyzed in full-water immersion, which is a research gap addressed within this approach to contribute to a better understanding of nitrogen narcosis. In this study, 20 young, healthy, and certified …

Different sensory aspects of a food are not remembered with equal acuity

2009

International audience; In the present study, food memory for three sensory aspects involved in food perception, taste, texture and aroma, is compared. Participants received a lunch including a custard dessert (target) under incidental learning condition. One day later, participants were presented with samples identical to the target and with distractors varying either in sweetness, thickness or cherry aroma. Memory was assessed by an absolute recognition question (“Did you eat this sample yesterday?”) and by relative questions (“Is this sample less, equal or more sweet than the sample you ate yesterday?”). Results showed better memory performance for sweetness than for the two other sensor…

“Following in the footprint of the teacher”: A methodological approach for the treatment of memory repression in the class

2017

La “represión de la memoria” es un fenómeno que reconstruye y tergiversa los recuerdos en torno al periodo de ciudadanía activa anterior a la Guerra Civil Española y en torno al brutal proceso represivo del régimen franquista, afectando así a la propia configuración de la sociedad actual. En este trabajo se realiza una diagnosis de este fenómeno en el espacio educativo y se presenta una propuesta didáctica que luche contra esta represión llevando la propia memoria al aula como objeto de estudio e intentando convertir a los alumnos en investigadores y, lo más importante, en ciudadanos críticos The “repressed memory” is a phenomenon that reconstructs and distorts memories around the active ci…

How to blend language and ICT in the didactics of scientific translation

2014

New information and communication technologies (ICT) have burst into all spheres of our lives, modifying them in ways inconceivable barely 10 years ago. Generally speaking, these modifications have enhanced interaction processes (telecommunications), work and human production (task automation). The field of professional translation has been particularly affected by this technological revolution and has led to new research, professional and didactic paradigms, known as Automatic Translation and Computer Aided Translation. This is the framework for our present work, which attempts to put together the development of communicative (linguistic) competences with procedural (instrumental) and eval…