Search results for "Memory"

GABAA agonist muscimol ameliorates learning/memory deficits in streptozocin-induced Alzheimer’s disease non-transgenic rat model

2015

Background: GABAergic inhibitory action regulates learning/memory processes and contributes to neurotransmission (Gong et al., 2009). Existing evidence suggests GABAergic system is involved in pathophysiology of Alzheimer’s disease (AD) via inhibitory interneuron deficits (Verret et al., 2012) and decrease in functional GABAA receptors (Limon et al., 2012). In vitro, GABA and muscimol (GABAA receptor agonist) blocked neuronal death induced by Aβ in rat hippocampal and cortical neurons (Paula-Lima et al., 2005). Our concept: low doses of muscimol may prevent learning/memory deficits in intracerebroventricular (icv) streptozocin (STZ)-induced AD non-transgenic rat model. Methods. Wistar male …

2021

The cell—cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality tra…

»…vzpomínám na něho ustavičně a přeji mu, aby se mu tatínek brzo vrátil«. O (terapeutycznej) roli pamięci w korespondencji więziennej Jana Zahradníčka

2020

Przedmiotem analizy są listy czeskiego poety Jana Zahradníčka wysyłane z komunistycznego więzienia do żony Marii w latach 1951–1960. Wybór to zapis zarówno życiowej traumy wynikającej z długo letniej izolacji oraz tragedii rodzinnej (śmierć dwóch córek), a jednocześnie świadectwo tego, że dzięki terapeutycznej roli pamięci autor przetrwał ów trudny czas. Punktem wyjścia są m. in. rozważania Aleidy Assmann, które co prawda prymarnie odnosiły się do pamięci kolektywnej społeczeństw dotkniętych traumatyczną przeszłością, ale mogą być także użyteczne dla rozpatrywanego tutaj studium przypadku jednostki.

Arithmetic Problems Formulation and Working Memory Load

1987

First, third, and fifth graders (French children in American-numbered grades) were asked to solve arithmetic problems in which an initial state was modified by two successive transformations. Three independent variables were manipulated systematically. First, the unknown state was either the final state (Sl) or the initial state (S2). Second, either the known state (01) or the transformations (02) appeared in the first place in the problem wording. Third, the question was either located at the end (Ql) or at the beginning (42) of the problem text. As anticipated, these modifications strongly affected the performances at every age: S1 appears clearly easier than S2; 0 1 leads to a better per…

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

2021

LRP1-targeted St-Cl–polyglutamate conjugates as multivalent neuroprotective/neurotrophic therapeutics for Alzheimer’s disease.

Aminobisphosphonate-activated γδ T cells in immunotherapy of cancer: doubts no more

2008

BACKGROUND: Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors. OBJECTIVE: We discuss the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in cancer patients. METHODS: The antitumoral effects of gammadelta T cells both in vitro and in vivo have been demonstrated suggesting a new therapeutic approach for translation into the clinical setting. RESULTS/CONCLUSION: V gamma 9 V delta 2 T lymphocytes represent a particularly interesting target for immunotherapeutic …

Selective erasure of a fear memory

2009

International audience; Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning b…

Dissociation between priming and recognition in the expression of sequential knowledge

2002

Exposure to a repeating sequence of target stimuli in a speeded localization task can support both priming of sequence-consistent responses and recognition of sequence components. Here, a task is introduced in which measures of priming and recognition are obtained concurrently, and it is demonstrated that priming of sequence-consistent responses occurs even when test stimuli are not recognized. The results show that sequence knowledge can be expressed in the absence of conscious recognition. However, we also show that this result is consistent with a simple model in which priming and recognition depend on exactly the same underlying memory strength variable.

[IC‐P‐152]: ASSOCIATION OF CORTICAL AMYLOID LOAD WITH RESTING‐STATE EEG FUNCTIONAL CONNECTIVITY IN SUBJECTIVE MEMORY COMPLAINERS FROM THE INSIGHT‐PRE…

2017

Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory

2018

Background Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined as executive control and storage process. Previous studies mainly focused on the overall effect of transcranial direct current stimulation (tDCS) on working memory. However, little has been known about the segregative effects of tDCS on the sub-processes within working memory. Method Transcranial direct current stimulation, as one of the non-invasive brain stimulation techniques, is being widely used to modulate the cortical activation of local brain areas. This study modified a spatial n-back experiment with anodal and cathodal tDCS exertion on th…