Search results for "Meta-analysis"

Accuracy of risk tools to predict critical bleeding in major trauma: A systematic review with meta-analysis.

2021

BACKGROUND Early detection of critical bleeding by accurate tools can help ensure rapid delivery of blood products to improve outcomes in major trauma patients. We conducted a systematic review to evaluate the accuracy of risk tools to predict critical bleeding in patients with major trauma. METHODS PubMed, Embase, and CENTRAL were searched up to February 2021 for studies investigating risk tools to predict critical bleeding for major trauma people in prehospital and emergency department. We followed the Preferred Reporting Items for Systematic Review and Meta-Analysis of Diagnostic Test Accuracy study guidelines. Two independent authors included studies, extracted data, appraised the quali…

Analysis of the Economic Research Context after the Outbreak of the Economic Crisis of 2007-2009

2015

In this paper it, we have conducted a factor analysis which implied determining the international research directions that have characterized the period following the outbreak of the crisis in 2007 and 2008-2011. In this research, we used secondary data that were extracted from 342 articles, which were based on 665 individual researches. Following this research, we have identified three main research in the macroeconomic areas which explained 56% of all the analyzed research. Also, the results showed the trends in macroeconomic research after the start of the crisis in 2007.

Are Socio-Demographic Factors Associated to Burnout Syndrome in Police Officers?: a Correlational Meta-Analysis

2017

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O26 Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Inf…

2019

BackgroundIn the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates.MethodsA ‘meta-model’ using NONMEM with 4894 concentrations from 1631 neonates was built and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming at reaching a target AUC0-24 of 400 mg*h/L at steady state in at least 80% of neonates.ResultsA two-compartment model best fitted the data. Current weight, post-menstrual age (PMA) and serum creatinine were the significant covariates for clearance (CL). After model validation, simulations showed that a loading dose (25 mg/kg) and a maintenance dose (15 mg/kg twice dail…

Palliative sedation in patients with advanced cancer followed at home: A systematic review

2011

Abstract Context Patients with advanced cancer who are near the end of life may experience intolerable suffering refractory to targeted palliative therapies. Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief. Objectives The aim of this study was to systematically review articles regarding PS performed at home in patients with intractable symptoms. Methods Literature databases searched included MedLine, PubMed, and EMBASE. The text words and MeSH/EMTREE terms "home care" and "sedation" were used for electronic database searches. Results Six articles met the inclusion criteria for research …

Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta…

2017

Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these cytokines have been published, and so we performed an updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD. The P…

GASTRIC CANCER (GC) ADJUVANT (A) CHEMOTHERAPY (CT): A LITERATURE BASED META-ANALYSIS (MA)

2010

Of Friends and Foes in Organizations: A Theoretical Perspective Upon Performance at Work

2014

Abstract The present paper highlights, from a theoretical perspective, the main challenges which aim work performance, inside meta- analytical research studies in organizations, focusing, especially, on factors and organizational concepts, directly related to performance and their relations within. Results show that, in most cases, human resources oriented management resides in an increase of performance at work. In this manner, team effectiveness, group size and proactive behavior determine and influence the levels of work performance, from a positive perspective, whilst turnover is widely associated with a negative view.

Should inflammatory pathways be targeted for the prevention and treatment of hypertension?

2019

Hypertension is the most common modifiable risk factor for cardiovascular disease (CVD)1 and is a leading cause of death globally.2 Hypertension and CVD share common antecedent risk factors which include physical inactivity, obesity and excess alcohol intake.3 Though these established risk factors explain a large proportion of hypertension risk, its pathogenesis is still not fully established as it appears that other additional lifestyle and genetic factors may be involved. There is therefore a need to identify and evaluate putative risk factors that may increase our knowledge of hypertension development, may have causal or predictive relevance, and which will help develop preventive and ma…

Identifying suitable proxies for climate change impacts in shallow Mediterranean habitats: sponge filtration not a ready-to-use tool yet

2009

The identi#cation of reliable proxies is crucial to undertake experimental manipulation and test hypotheses on climate change impacts. We evaluated the potential use of sponge #ltering activity as a proxy for the e$ect of temperature (T) increase in shallow marine habitats since: i) Porifera are ubiquitous, sessile and long-lived aquatic organisms; ii) Porifera are active #lter feeders and play a key-role in benthic-pelagic coupling; iii) #ltering activity already proved reliable to detect T e$ects on bivalves. The systematic screening of current literature to gather data and test the assumption “T increase -> increase in sponge #ltering activity” led to a #rst list of 840 sources (title re…