Search results for "Mora"
showing 10 items of 1952 documents
Memoria oral y alimentación: estrategias de supervivencia durante la Guerra Civil Española (1936-1939) y la posguerra (1939-1955)
2011
El principal objetivo de nuestro tra bajo es delimitar las prácticas de reciprocidad que se llevaron a cabo durante el período de tiempo analizado y que permitieron reproducirse socialmente a los grupos menos favorecidos por la guerra y la posguerra . Nuestro análisis demuestra que la alimentación es un sistema de comuni - cación mediante el cual se crean o mantienen prácticas de poder , así como expre - siones de identidad y/o defensa o ruptura de las normas morales que comparte un grupo social .
Europa, el placer y la moral
1998
Textes à l'appui entre 1989 et 1991
1988
Usted no, señor Kissinger
2001
RECENSIONE DI MASSIMO LA TORRE, NOSTRA LEGGE È LA LIBERTÀ. ANARCHISMO DEI MODERNI, DERIVE APPRODI, ROMA 2017
2018
Il testo qui recensito costituisce un sasso nello stagno del dibattito sulla giustificazione delle istituzioni giuridiche, sasso lanciato da uno dei più eminenti filosofi del diritto italiani. Il sasso è costituito dalla dottrina politica “anti-giuridica” per definizione: l’anarchismo. E che tale sasso sia lanciato in uno “stagno”, e non in un “torrente” di idee, ci sembra dato dal fatto che ormai sembra cristallizzato un consenso generale tra i filosofi del diritto circa il primato del liberalismo politico (J. Rawls), o di forme di repubblicanesimo parassitarie del liberalismo politico (J. Habermas), su altre dottrine politiche alternative quando si discute dell’obbligo di obbedire al diri…
IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
2012
Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of Vγ9Vδ2 cells with phosphoantigen and IL-21 leads to selective expression of the transcription repressor Bcl-6 and polarization toward a lymphocyte subset displaying features of follicular B-helper T (T(FH)) cells. T(FH) like Vγ9Vδ2 cells have a predominant central memory (CD27(+)CD45RA(-)) phenotype and express ICOS, CD40L and CXCR5. Upon antigen activation, they secrete IL-4, IL-10 and CXCL13, and provide B-cell help for antibody production in vitro. Our findings delineate a subset of human Vγ9Vδ2 lymphocytes, which, upon interaction w…
Moraalisten ja esteettisten arvostelmien suhde taiteessa : katsaus kohtuullisiin teorioihin
2015
Tämä tutkielma käsittelee moraalisten ja esteettisten arvostelmien suhdetta taiteessa keskittyen kolmeen kohtuulliseksi teoriaksi katsottuun näkemykseen: Noël Carrollin kohtuulliseen moralismiin, Berys Gautin etikismiin sekä Andersonin ja Deanin kohtuulliseen autonomismiin. Tarkoitukseni on selvittää, millä tavalla kukin näistä teoreetikoista näkee taiteen moraalin ja estetiikan suhteen. Tutkimuskysymyksessäni haluan ottaa selvää, onko taiteessa sekä moraalisia että esteettisiä arvostelmia ja vaikuttavatko nämä toisiinsa. Ennen siirtymistä varsinaisiin kohtuullisiin teorioihin pohjustan aihetta selvittämällä, kuinka taiteen moraaliin ja estetiikkaan on suhtauduttu historian kuluessa ja mite…
Study of the antitumor effect of inducible nitric oxide synthase in a breast cancer model : analysis of molecular mechanisms
2013
The anti -tumor effect of a lipid A, OM -174 (lipid portion of LPS) was studied in a model of breast cancer in mice. In vivo, OM- 174 increases the survival of mice whereas in vitro it is not toxic to cancer cells. OM -174 binds to TLR4 immune cells inducing the production of cytokines such as IFNγ. In vitro, the combination of IFNγ to lipid A is cytotoxic. The objective of this thesis is to analyze those molecular mechanisms. We have shown both in vitro and in vivo that the cytotoxicity of the lipid A / IFNγ is dependent of TLR4 and of the receptor for IFNγ, and the NOS II expression. We also showed that the radical species, NO and superoxide anion forming peroxynitrite play a crucial role…
Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures
2017
Glycoprotein research is pivotal for vaccine development and biomarker discovery. Many successful methodologies for reliably increasing the antigenicity toward tumor-associated glycopeptide structures have been reported. Deeper insights into the quality and specificity of the raised polyclonal, humoral reactions are often not addressed, despite the fact that an immunological memory, which produces antibodies with cross-reactivity to epitopes exposed on healthy cells, may cause autoimmune diseases. In the current work, three MUC1 antitumor vaccine candidates conjugated with different immune stimulants are evaluated immunologically. For assessment of the influence of the immune stimulant on a…
The interplay between the immune system and chemotherapy: emerging methods for optimizing therapy.
2013
Preclinical studies have revealed an unexpected ability of the immune system to contribute to the success of chemotherapy and radiotherapy. Anticancer therapies can trigger immune system activation by promoting the release of danger signals from dying tumor cells and/or the elimination of immunosuppressive cells. We have, however, recently discovered that some chemotherapies, such as 5-fluorouracil and gemcitabine, exert conflicting effects on anticancer immune responses. Although 5-fluorouracil and Gem selectively eliminated myeloid-derived suppressive cells in tumor-bearing rodents, these chemotherapies promoted the release of IL-1β and the development of pro-angiogenic IL-17-producing CD…