Search results for "Mutagenesis"
showing 10 items of 2483 documents
Cytotoxic and genotoxic effects of electronic cigarette liquids on human mucosal tissue cultures of the oropharynx
2016
The popularity of electronic cigarettes (ECs) is rapidly growing and ECs are claimed to be an uncritically regarded alternative to conventional cigarettes. The mucosal tissue of the upper aerodigestive tract (UADT) is the first contact organ for xenobiotics such as liquids of ECs. The aim of this study is to investigate the bimolecular effects of e-liquids on human pharyngeal tissue cultures to evaluate whether e-liquids and their components present a risk factor for head and neck squamous cell carcinoma. Fresh tissue samples of healthy oropharyngeal mucosa were assembled into mucosal tissue cultures. Two fruit-flavored liquids (FLs), one tobacco-flavored liquid (TL) (all containing nicotin…
Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation
2012
Background The human prion diseases are a group of universally fatal neurodegenerative disorders associated with the auto-catalytic misfolding of the normal cell surface prion protein (PrP). Mutations causative of inherited human prion disease (IPD) include an insertion of six additional octapeptide repeats (6-OPRI) and a missense mutation (P102L) with large families segregating for each mutation residing in southern England. Here we report for the first time the neuropsychological and clinical assessments in these two groups. Method The cognitive profiles addressing all major domains were obtained for 26 patients (18 6-OPRI, 8 P102L) and the cortical thickness determined using 1.5T MRI in …
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.
2006
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete re…
Examining the Dynamics of the Implicit and the Explicit Self-Concept in Social Anxiety: Changes in the Implicit Association Test–Anxiety and the Soci…
2008
In this study, we analyzed changes in the strength of self-anxiety associations—as measured by the Implicit Association Test–Anxiety (IAT–Anxiety; Egloff & Schmukle, 2002) and the Social Phobia Anxiety Inventory (SPAI; Turner, Beidel, Dancu, & Stanley, 1989)—following treatment of social anxiety. We assessed socially anxious participants (N = 24) prior to and following a group-based treatment; and we assessed healthy controls (N = 24) at matched time points. Results showed (a) higher implicit and explicit anxiety in socially anxious participants (as compared to controls) prior to treatment and (b) reductions in IAT–Anxiety and SPAI scores of socially anxious participants following treatment…
From Happiness Orientations to Work Performance: The Mediating Role of Hedonic and Eudaimonic Experiences
2019
In organizations, psychologists have often tried to promote employees&rsquo
Immunologic findings in workers formerly exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners
1998
One hundred ninety-two workers in a German pesticide factory who were exposed to polychlorinated dibenzodioxins and -furans (PCDD/PCDF) were investigated for former and present diseases and laboratory changes of the immune system. Moreover, in a subgroup of 29 highly exposed and 28 control persons, proliferation studies were performed. In addition to assays such as blood count, immunoglobulins, serum electrophoresis, monoclonal bands, surface markers, autoantibodies, and lymphocyte proliferation, two new methods, the rise of tetanus antibody concentration after vaccination and the in vitro resistance of lymphocytes to chromate, were used to diagnose the morphologic and functional state of t…
The Basic Psychological Need Satisfaction and Frustration Scale: Construct and Predictive Validity in the Italian Context
2020
The Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) is a self-report instrument assessing the satisfaction and frustration of the three basic psychological needs of autonomy, competence, and relatedness defined by self-determination theory. The aim of this study was to examine the dimensionality, the predictive validity, and the measurement invariance across different age groups of the Italian version of the BPNSFS. The participants were 2,204 Italian adolescents and young adults (41% males) from 14 to 28 years old (M age = 20.23, SD = 4.25). The invariance across age demonstrated adequate equivalence of the 6-factor model of scales across adolescents (14–18 years) and …
Temporal stability of the implicit association test-anxiety.
2005
The Implicit Association Test-Anxiety (IAT-Anxiety; Egloff & Schmukle, 2002) provides an indirect assessment of anxiety by measuring associations of self (vs. other) with anxiety-related (vs. calmness-related) words. In 3 studies (using 3 independent samples), we examined the temporal stability of the IAT-Anxiety. In Study 1, 65 participants responded twice to the IAT-Anxiety with a time lag of 1 week. The test-retest correlation was .58. In Study 2 (N = 39), we extended the time interval between test and retest to 1 month and this yielded a stability coefficient of .62. In Study 3 (N = 36), we examined the long-term stability (time lag: 1 year) of the IAT-Anxiety and this showed a correlat…
Changes in Salivary Levels of Creatine Kinase, Lactate Dehydrogenase, and Aspartate Aminotransferase after Playing Rugby Sevens: The Influence of Gen…
2020
Rugby sevens is characterised by continuous exertion and great physical contact per unit of time, leading to muscle damage. It is important to identify markers that can quantify muscle damage in order to improve recovery strategies. The objective of this study was to evaluate the release dynamics of muscle damage markers creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) in saliva samples when playing rugby sevens, analysing the influence of gender, during the rugby sevens university championship of Spain. The total sample included 27 athletes, divided into two teams of 14 men and 13 women between 18 and 31 years of age. CK, LDH, and AST were quantified …
Chronic occupational noise exposure: Effects on DNA damage, blood pressure, and serum biochemistry
2019
Abstract Noise levels experienced by industrial workers may cause both auditory and non-auditory harmful effects. We have studied the effects of chronic industrial noise exposure on DNA damage, blood pressure, and serum biochemistry in factory workers. Male workers (109 individuals) in three parts of a food factory in Shahroud, Iran were enrolled as the exposed group and male office workers (123 individuals) were the unexposed control group. Noise exposure was measured (dosimetry) and the comet assay was used to evaluate DNA damage in peripheral blood mononuclear cells. Glutathione peroxidase (GPx) and ceruloplasmin (Cp) levels were measured in serum samples. GPx levels, systolic and diasto…