Search results for "N 1"

showing 10 items of 1053 documents

Epigenetic Regulation of Early- and Late-Response Genes in Acute Pancreatitis

2015

Abstract Chromatin remodeling seems to regulate the patterns of proinflammatory genes. Our aim was to provide new insights into the epigenetic mechanisms that control transcriptional activation of early- and late-response genes in initiation and development of severe acute pancreatitis as a model of acute inflammation. Chromatin changes were studied by chromatin immunoprecipitation analysis, nucleosome positioning, and determination of histone modifications in promoters of proinflammatory genes in vivo in the course of taurocholate-induced necrotizing pancreatitis in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-α. Here we show that the upregulat…

Taurocholic AcidTranscriptional Activation0301 basic medicineChromatin ImmunoprecipitationImmunologyAcinar CellsBiologyMethylationChromatin remodelingEpigenesis GeneticHistones03 medical and health sciences0302 clinical medicineHistone methylationAnimalsImmunology and AllergyNucleosomeEpigeneticsPromoter Regions GeneticEarly Growth Response Protein 1Histone AcetyltransferasesInflammationPancreatitis Acute NecrotizingTumor Necrosis Factor-alphaDNA HelicasesNuclear ProteinsAcetylationHistone acetyltransferaseChromatin Assembly and DisassemblyRatsChromatin030104 developmental biologyHistoneGene Expression Regulation030220 oncology & carcinogenesisbiology.proteinCancer researchProtein Processing Post-TranslationalChromatin immunoprecipitationTranscription FactorsThe Journal of Immunology
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Termo- e foto- degradazione di nano compositi a base di nylon 11

2016

Negli ultimi anni la poliammide 11 (PA11) ha suscitato un notevole interesse in svariati settori industriali industriali.Per ottimizzare la comprensione dei meccanismi che governano la termo e foto ossidazione della PA11, sono stati studiati mediante Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) , cromatografia ad esclusione sterica (SEC) e viscosimetria, i processi di degradazione termo e foto-ossidativi che interessano il PA11 ed in particolare i nanocompositi formulati con Cloisite30B

Termo-ossidazione foto-degradazione nanocompositi nylon 11
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A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease

2010

OBJECTIVES: Behçet's disease has been historically classified as a Th1 disease. The recently described IL-17/IL-23 pathway seems to play an important role in many inflammatory diseases and in the intestinal abnormalities of AS and CD. The aim of the present study was to evaluate the IL-17/IL-23 axis in parallel with Th1 and IL-27 response in the intestine of patients with BD and gastrointestinal abnormalities. METHODS: Quantitative TaqMan reverse transcriptase-polymerase chain reaction (RT-PCR) was utilised for all determinations on ileal biopsy specimens obtained from BD, AS and CD patients. The serum levels of Th1 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay. RES…

Th1BehcetTh17Behcet interleukin 17 Th17 Th1interleukin 17
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La stereotomia nella cattedra di Architettura statica di Carlo Giachery

2014

La scuola di architettura di Palermo, sin dalla sua fondazione nel 1779, con la creazione della cattedra di Architettura civile affidata a Giuseppe Venanzio Marvuglia, era divenuta inevitabilmente il luogo di verifica e talvolta di esplorazione dei temi legati alla pratica professionale e, quindi, all’arte del costruire. Giachery, Professore di Architettura statica e civile dal 1837 al 1865, è il primo ad avvertire, da docente, la crisi profonda del sistema didattico della scuola di architettura di Palermo isterilita dalla ricerca di astratte idealità neoclassiche e straniatasi dal processo evolutivo della cultura architettonica europea dopo la morte dei “maestri” Marviglia e Gentile. Secon…

The School of Architecture of Palermo since its founding in 1779 with the creation of the chair of Civil Architecture entrusted to Joseph Venantius Marvuglia has become the place of testing exploration of issues related to professional practice and the art of building. Carlo Giachery Professor of Static and Civil Architecture from 1837 to 1865 is the first to feel the deep crisis of the educational system of the school of architecture of Palermo. For him architecture and applied sciences to architecture found in their stereotomy confirmation of the existence of correspondent relationships in their evolutionary process. The notion of stereotomy taken by Carlo Giachery in teaching reconnects directly to the noble art of coupe des pierres. Taken together the teaching aids used to show a theoretical advance that Giachery inclined in the direction of elasticity of the materials. Noting the outcomes of teaching his students have the clear perception of how the teaching on stereotomy is the compendium of all the French tradition on the subject. With the establishment of the School of Application for Engineers and Architects in 1866 the steretomia seems to gradually lose interest in favor of the prevailing metal construction. All the wisdom of build which for centuries had been linked with art de la coupe des pierres gave way to new construction techniques and new materials.Settore ICAR/14 - Composizione Architettonica E Urbana
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Ultreya, suseya, Santiago!” Viaggio e spazialità ne La ballata dei pellegrini

2020

Per studiare dal punto di vista della geografia culturale alcuni aspetti del pellegrinaggio a Santiago de Compostela, in Spagna, il capitolo prende in considerazione un testo letterario, il romanzo autobiografico "La ballata dei pellegrini" della scrittrice francese Edith De La Héronnière, pubblicato per la prima volta nel 1993 e tradotto in italiano nel 2004. Il romanzo racconta l’esperienza del pellegrinaggio giacobeo effettuato dall’autrice negli anni Novanta assieme a tre compagni di viaggio partendo da un cammino francese. In particolare, attraverso l’analisi di alcune parti del testo, si indagano le modalità attraverso le quali la narrazione costruisce e descrive lo spazio fisico e si…

The contribution critically and from a geographical perspective discusses the connection between propaganda comics and cartoons in the period of twentieth-century totalitarianisms. The way in which space real and symbolic is implicated through the rhetoric and dialectics of power in social economic and identity dynamics is then explored. In order to study some aspects of the pilgrimage to Santiago de Compostela from the point of view of cultural geography in Spain the chapter takes into consideration a literary text the autobiographical novel "The pilgrims' ballad" by the French writer Edith De La Héronnière first published in 1993 and translated into Italian in 2004. The novel recounts the experience of the Jacobean pilgrimage carried out by the author in the nineties together with three traveling companions starting from a French journey. In particular through the analysis of some parts of the text the ways in which the narration constructs and describes the physical and symbolic space of the pilgrimage are investigated. In this way it is possible to explore the way in which peculiar attributions of meaning inscribe the experience of pilgrimage in a symbolic universe that is both personal and collective at the same time.
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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A novel mutation (Thr116IIe) in the presenilin 1 gene in a patient with early-onset Alzheimer's disease

2004

We report a novel presenilin 1 (PSN1) mutation (Thr116Ile) in a woman with early onset Alzheimer's disease (AD). This mutation was not found in 100 healthy controls, indicating that this is not a common polymorphism. The patient presented with forgetfulness at age 45, followed over the next 3 years by a worsening of the memory loss and frequent episodes of confusion and spatial disorientation. Neuroimaging studies were consistent with AD. The analysis of the family's pedigree showed that the proband was apparently the only member affected. Because the early death of several close relatives (i.e. the mother and the grandmother) and the demonstration that the father is not a mutation carrier,…

ThreonineProbandDNA Mutational AnalysisDiseaseBioinformaticsGenetic analysisPresenilinMutation CarrierAlzheimer DiseasePolymorphism (computer science)Presenilin-1medicineHumansEarly-onset Alzheimer's diseaseIsoleucineGeneticsbusiness.industryMembrane ProteinsMiddle Agedmedicine.diseaseNeurologyMutationMutation (genetic algorithm)FemaleSettore MED/26 - NeurologiaNeurology (clinical)businessAlzheimer's Disease Novel mutation Presenilin 1
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NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins.

2013

The transmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells (OPC), which migrate to axons during developmental myelination and remyelinate in the adult after migration to injured sites. Highly invasive glial tumors also express NG2. Despite the fact that NG2 has been implicated in control of OPC migration, its mode of action remains unknown. Here, we show in vitro and in vivo that NG2 controls migration of OPC through the regulation of cell polarity. In stab wounds in adult mice we show that NG2 controls orientation of OPC toward the wound. NG2 stimulates RhoA activity at the cell periphery via the MUPP1/Syx1 signaling pathway, which favors the bipolar shape of migrat…

Threoninerho GTP-Binding ProteinsRHOAPolarity (physics)CellNerve Tissue ProteinsGTPaseBiologyCell MovementAucun;physiologyCell polaritymedicineGuanine Nucleotide Exchange FactorsHumansT-Lymphoma Invasion and Metastasis-inducing Protein 1genetics;physiologyAntigensPhosphorylationCell ShapeTight Junction ProteinsGeneral NeuroscienceChemotaxisStem CellsCell PolarityArticlesTransmembrane proteinCell biologyrac GTP-Binding ProteinsOligodendrogliamedicine.anatomical_structurenervous systembiosynthesis;geneticsphysiologybiology.proteinPhosphorylationRNAProteoglycansRNA InterferenceSignal transductionmetabolismSignal Transduction
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A novel and rapid prediction assay for the effectiveness of IL-6 receptor specific antisense oligonucleotides by proliferation inhibition of an inter…

2001

Interleukin-6 (IL-6) belongs to a family of cytokines that use receptors consisting of a common signal-transducing chain (gp130). Baf/3 cells transfected with the human IL-6 receptor (IL-6R) and gp130 (Baf/3-gp130/IL-6R) can only grow in medium containing IL-6. We attempted to interrupt the signal transducing pathway of IL-6 with the help of antisense oligonucleotides (ASOs) designed against the IL-6R. We used 18 different kinds of antisense oligonucleotides of overlapping sequences around the translational start codon of the human IL-6R. Sense ASOs were used as a control. The proliferation of cells was analysed by H-thymidine incorporation. Cell surface expression of the IL-6R was assessed…

Time FactorsCellBiologyCell LineSubstrate SpecificitySense (molecular biology)medicineHumansReceptorInterleukin 6Base SequenceInterleukin-6Cell BiologyGeneral MedicineTransfectionOligonucleotides AntisenseGlycoprotein 130Flow CytometryMolecular biologyReceptors Interleukin-6medicine.anatomical_structureCell cultureInterleukin-6 receptorbiology.proteinCell DivisionSignal TransductionCell biology international
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Cytokine- and Interferon-Modulating Properties of Echinacea spp. Root Tinctures Stored at −20°C for 2 Years

2007

Echinacea spp. phytomedicines are popular for treating upper respiratory infections. The purpose of this investigation was to examine the immunomodulatory properties of Echinacea tinctures from seven species after being stored at -20 degrees C for 2 years. Two experimental techniques were employed using human peripheral blood mononuclear cells (PBMC). In the first set of experiments, PBMCs were stimulated in vitro with tinctures alone and assayed for proliferation and production of interleukin-10 (IL-10), IL-12, and tumor necrosis factor-alpha (TNF-alpha). In the second set of experiments, subjects were immunized with influenza vaccine. PBMCs from vaccinated individuals were stimulated in v…

Time FactorsDrug StorageImmunologyPeripheral blood mononuclear cellPlant RootsVirusArticleEchinaceaCytokine interferon Echinacea immunologyEchinacea (animal)Interferon-gammaImmune systemSpecies SpecificitySettore BIO/13 - Biologia ApplicataInterferonVirologymedicineHumansInterferon gammaCells CulturedCell ProliferationCryopreservationTraditional medicinebiologyPlant ExtractsTumor Necrosis Factor-alphaCell Biologybiology.organism_classificationInterleukin-12Interleukin-10Interleukin 10AlcoholsImmunologyInterleukin 12Leukocytes MononuclearCytokinesmedicine.drug
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