Search results for "Neste"
showing 10 items of 639 documents
GABA-A receptoru agonista muscimola ietekme uz acetilholīna daudzumu Alcheimera slimības tipa modeļdzīvnieku smadzenēs
2017
Šī darba mērķis bija noskaidrot muscimola ļoti zemu devu (0,01 un 0,05 mg/kg) efektus uz acetilholīna šķelšanu intracerebroventrikulāras (i.c.v.) streptozocīna (STZ) ievadīšanas AD-tipa modelī. Rezultāti rāda, ka: 1.STZ i.c.v. ievadīšana izraisīja būtisku garozas un hipokampa AChE blīvuma palielinājumu. 2.Muscimols 0,01 un 0,05 mg/kg devās normalizēja AChE blīvumu STZ grupas žurku garozā un hipokampā līdz kontroles grupas līmenim. Iegūtie dati ļauj secināt, ka muscimola ļoti mazas devas regulē acetilholīna daudzumu i.c.v. STZ modelī. Iespējams, šis regulācijas mehānisms atbild par iepriekš novērotiem telpiskās atmiņas uzlabojumiem AD-tipa modeļdzīvniekos, tomēr ir nepieciešami tālāki pētīju…
Neuroinflammation and acetylcholinesterase overexpression as the main targets for low doses of GABA-A receptor agonists in Alzheimer's disease rat mo…
2018
Noturīgo organisko piesārņotāju noteikšana Latvijas gliemenēs
2018
Noturīgo organisko piesārņotāju noteikšana Latvijas gliemenēs. Ikkere L.E., zinātniskais vadītājs Asoc. prof. Dr. chem. Vadims Bartkevičs. Maģistra darbs, 51 lappuse, 14 attēli, 11 tabulas, 74 literatūras avoti, 3 pielikumi. Latviešu valodā. Darba literatūras apskatā ir apkopota vispārīgā informācija par dažādām piesārņotāju klasēm. Izveidots plašs pārskats par pētīto piesārņotāju izplatību gliemenēs visā pasaulē, kā arī novērtēti iespējamie piesārņojuma avoti. Maģistra darbā vides piesārņojuma novērtēšanai Latvijā tika izmantotas gliemenes kā indikatororganismi. Tika analizēti divdesmit četri gliemeņu paraugi no Latvijas upēm un ezeriem. Paraugos noteiktas četras piesārņotāju grupas – poli…
What motivates the adoption of green restaurant products and services? A systematic review and future research agenda
2021
Issues regarding green restaurants have received significant scholarly and practitioner attention in the last decade, particularly concerning why consumers adopt green restaurants. Although several reviews exist on green hospitality, a comprehensive review of the literature on consumers' green restaurant adoption is currently lacking. The following systematic literature review examines 50 research studies published on the consumer adoption of green restaurant services to address this gap accordingly. Through a detailed content analysis, the research profile and thematic analysis are presented. The review further identifies four key thematic foci: (a) consumer behavior variables studied, (b)…
2014
Introduction: Many studies examine gene expression data that has been obtained under the influence of multiple factors, such as genetic background, environmental conditions, or exposure to diseases. The interplay of multiple factors may lead to effect modification and confounding. Higher order linear regression models can account for these effects. We present a new methodology for linear model selection and apply it to microarray data of bone marrow-derived macrophages. This experiment investigates the influence of three variable factors: the genetic background of the mice from which the macrophages were obtained, Yersinia enterocolitica infection (two strains, and a mock control),and treat…
BODIPY dyes functionalized with 2-(2-dimethylaminophenyl)ethanol moieties as selective OFF–ON fluorescent chemodosimeters for the nerve agent mimics …
2014
[EN] Two OFF-ON fluorescent chemodosimeters based on a BODIPY core for the detection of nerve agent mimics have been synthesized. Their reactivity towards diethylcyanophosphonate (DCNP) and diisopropylfluorophosphate (DFP) has been tested in organic and aqueous phase. These chemodosimeters selectively detect the nerve agent mimics with good LODs. The chemodosimeters hold their sensing properties on solid supports, allowing the preparation of a hand held sensing kit. The sensing in solid-liquid phase has been demonstrated. The X-ray structure of compound 2 has been resolved.
Face Inpainting via Nested Generative Adversarial Networks
2019
Face inpainting aims to repaired damaged images caused by occlusion or cover. In recent years, deep learning based approaches have shown promising results for the challenging task of image inpainting. However, there are still limitation in reconstructing reasonable structures because of over-smoothed and/or blurred results. The distorted structures or blurred textures are inconsistent with surrounding areas and require further post-processing to blend the results. In this paper, we present a novel generative model-based approach, which consisted by nested two Generative Adversarial Networks (GAN), the sub-confrontation GAN in generator and parent-confrontation GAN. The sub-confrontation GAN…
Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice
2013
Mildronate, a carnitine congener drug, previously has been shown to provide neuroprotection in an azidothymidine-induced mouse model of neurotoxicity and in a Parkinson's disease rat model. The aim of this study was to investigate the effects of mildronate treatment on cognition and pathology in Alzheimer's disease (AD) model mice (APP(SweDI)). Mildronate was administered i.p. daily at 50 or 100 mg/kg for 28 days. At the end of treatment, the animals were behaviorally and cognitively tested, and brains were assessed for AD-related pathology, inflammation, synaptic markers, and acetylcholinesterase (AChE). The data show that mildronate treatment significantly improved animal performance in w…