Search results for "Nose"
showing 10 items of 1793 documents
The risk of minor depression in families of probands with major depression: sex differences and familiality.
1992
Currently it is not clear whether minor forms of unipolar depression not matching the criteria of “major depression” should be considered as a separate diagnostic category. A controlled family study examined the familial aggregation of minor depression among probands with unipolar major depression. In the families of these probands the relative risk for minor depression was elevated by a similar magnitude to the risk for major depression. Threrefore, the diagnostic category “minor depression” would not increase diagnostic sensitivity at the expense of diagnostic specificity as far as familiality is the criterion. In agreement with recent epidemiological studies, minor depression did not rev…
The impact of the endogenous subtype on the familial aggregation of unipolar depression.
1991
The endogenous/non-endogenous distinction of unipolar major depression is widely accepted, as is the family study approach to the validation of diagnostic distinctions. Rates of affective disorders were examined in 689 first-degree relatives of 184 patients with unipolar major depression and were compared with 312 first-degree relatives of 80 healthy controls. Only unipolar depression and alcoholism were more common in families of depressed probands compared with families of healthy controls. As a variety of diagnostic definitions of endogenous depression have been proposed, probands and relatives were diagnosed in a polydiagnostic manner. None of the five diagnostic definitions of endogeno…
Propeller Flaps: A Review of Indications, Technique, and Results
2014
In the last years, propeller flaps have become an appealing option for coverage of a large range of defects. Besides having a more reliable vascular pedicle than traditional flap, propeller flaps allow for great freedom in design and for wide mobilization that extend the possibility of reconstructing difficult wounds with local tissues and minimal donor-site morbidity. They also allow one-stage reconstruction of defects that usually require multiple procedures. Harvesting of a propeller flap requires accurate patient selection, preoperative planning, and dissection technique. Complication rate can be kept low, provided that potential problems are prevented, promptly recognized, and adequate…
Systems Biology and immune aging
2014
Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a given biological system. Systems Biology benefits from the continuous advances in the omics sciences, based on high-throughput and high-content technologies, as well as on bioinformatic tools for data mining and integration. The Systems Biology approach is becoming gradually used to propose and to test comprehensive models of aging, both at the level of the immune system and the wh…
Biological properties of extracellular vesicles and their physiological functions
2015
The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202). In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive invest…
Adaptative biochemical pathways and regulatory networks in Klebsiella oxytoca BAS-10 producing a biotechnologically relevant exopolysaccharide during…
2012
Abstract Background A bacterial strain previously isolated from pyrite mine drainage and named BAS-10 was tentatively identified as Klebsiella oxytoca. Unlikely other enterobacteria, BAS-10 is able to grow on Fe(III)-citrate as sole carbon and energy source, yielding acetic acid and CO2 coupled with Fe(III) reduction to Fe(II) and showing unusual physiological characteristics. In fact, under this growth condition, BAS-10 produces an exopolysaccharide (EPS) having a high rhamnose content and metal-binding properties, whose biotechnological applications were proven as very relevant. Results Further phylogenetic analysis, based on 16S rDNA sequence, definitively confirmed that BAS-10 belongs t…
Opinion of the Patients About an Internet-Based Psychological Treatment Protocol
2015
Emotional disorders (depression and anxiety disorders) are highly prevalent. Currently, there is evidence showing the efficacy of disorder-specific cognitive-behavior therapy for emotional disorders. However, high comorbidity rates among emotional disorders have led some researchers to shift the focus to treatment strategies that might be more widely effective across these diverse conditions (transdiagnostic approach). Another important line of research in the literature is Internet-based psychotherapy. An increasing number of meta-analyses have shown the efficacy and effectiveness of Internet-based cognitive-behavior treatment protocols for emotional disorders. Nevetherless, little is know…
Serotonin dysfunction syndromes: a functional common denominator for classification of depression, anxiety, and obsessive-compulsive disorder.
1993
Pensamientos intrusos en obsesivos subclínicos : contenidos, valoraciones, estrategias de control
2003
Recent cognitive theories of obsessions consider that they differ from unwanted intrusive thoughts (IT) in terms of frequency of ocurrence, valorative appraisals, and thought control strategies. This paper examines that assumption comparing the responses provided by normal (N= 239) and subclinical (N=28) subjects to the following instruments: Revised Obsessional Intrusions Inventory (ROII), Maudsley Obsessive Compulsive Inventory (MOCI), BDI, and STAIS. Significant relationships were obtained among all the instruments, and the association between ROII and MOCI was maintained when depression scores were partialled out. Subclinically obsessive scored higher than normals on depressive, anxious…