Search results for "Note"

Promoting Deoxygenation of Bio-Oil by Metal-Loaded Hierarchical ZSM-5 Zeolites

2016

3 Figuras.- 5 tablas.-1 Esquema.- This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.5b01606 ”

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

2017

Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehens…

Innovative strategies to treat skin wounds with mangiferin: fabrication of transferosomes modified with glycols and mucin

2020

Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico–chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their pr…

Trends in Online Intube Solid Phase Microextraction

2017

BIO-Bragg gratings: structured molecular networks for on-fiber bioanalysis

2021

The research on photonic biosensors is a scientific hot topic at the moment, with a significant potential impact on industry and medicine. Label-free, miniaturized, inexpensive and low-loss biosensors are developed based on optical fiber technology. Our approach is based on a Bio-Bragg-Grating (BBG) patterned on the surface of a microfiber. We present the design, fabrication and proof of concept of our device, as well as its multiplexing and tunability perspectives [1] .

A class-selective immunoassay for simultaneous analysis of anilinopyrimidine fungicides using a rationally designed hapten

2017

he development of multianalyte immunoassays constitutes a main research issue in the field of bioanalytical techniques. In the present study, class-specific antibodies against the three members of the anilinopyrimidine family of fungicides (pyrimethanil, cyprodinil and mepanipyrim) were raised by using a bioconjugate of a rationally designed hapten [5-(6-methyl-2-(phenylamino)pyrimidin-4-yl)pentanoic acid]. Highly sensitive immunoassays were developed for the generic determination of these compounds, using the competitive enzyme-linked immunosorbent assay (ELISA). Particularly, a direct antibody-coated competitive ELISA afforded identical sensitivity for the three anilinopyrimidines, with I…

Smart materials for sample preparation in bioanalysis: A green overview

2021

Abstract The analysis of biological samples is a complex challenge due to the complexity of the matrix, but also to the low concentration of target analytes that must be determined. Consequently, different sample treatment procedures have been proposed in bioanalysis to clean-up and enrich sample extracts, paying special attention to microextraction approaches. In this frame, the combined use of microextraction approaches with smart materials provides environmentally friendly sample treatment strategies with improved selectivity, sensitivity, and reusability. Applications of smart solid materials includes antibody–antigen interaction based materials, aptamers, molecularly imprinted polymers…

Hybrid, multiplexed, functional DNA nanotechnology for bioanalysis

2015

We herein aim to report on the fabrication of DNA nano-heterostructures usable as a robust multi-functional analytical system to obtain multiple and complex data in parallel format from a single sample with unprecedented analytical performances. The ability of chemical information contained in the sequences of programmed DNA structures to organize matter made DNA become a unique material in “the nanoworld”. Such carefully designed DNA nanostructures can then be functionalized/templated with different biomolecules/nanomaterials as different as nanoparticles, nanowires, organic molecules, peptides, and proteins with controlled spacing on the nanometer scale (<10 nm). In this way, it is possib…

Bioaugmentācijas pielietošana notekūdeņu dūņu pārstrādes stimulēšanai

2020

Pirms dūņas varētu izmantot, kā augsnes mēslojumu, tās ir jāstabilizē, samazinot patogēnu, toksisko un organisko vielu daudzumu, kā arī samazinot smakojošu materiālu rašanos. Darba mērķis bija raksturot bioaugmentācijas un salmu pievienošanas ietekmi notekūdeņu dūņu paraugiem to pārstrādes stimulēšanai. Lai šo mērķi sasniegtu, dažādās kombinācijās, tika izveidoti dūņu, salmu, mikroorganismu un ūdeni saturoši eksperimentālie paraugi. Mikroorganismu elpošanas intensitāte, dažādu fizioloģisko grupu KVV skaits, kā arī veidotā amonjaka daudzums un fitotoksiskums tika uzskatīti kā svarīgākie parametri izvirzītā darba mērķa sasniegšanai. Darba rezultāti sniedz informāciju, ka kviešu salmi un bioau…

Development of controlled release systems of biocides for the conservation of cultural heritage

2017

Abstract The presence of microorganisms is one of the main causes of monument deterioration. Biocides are usually applied after or before restoration in order to prevent or slow down microbial growth. Frequent applications are necessary leading to increased costs and high risks to humans and the environment. The aim of this study is the design of novel controlled release systems comprising a biocide loaded into a mesoporous silica. Pristine MCM41 as well as MCM41 functionalised with carboxy- (MCM41-COOH) and amino-groups (MCM41-NH2) were used. Biotin T and New Des 50, two commercial formulations, were chosen as biocides. The biocide encapsulation was performed adding the mesoporous silica t…