Search results for "OGD"
showing 10 items of 25 documents
Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency
2016
International audience; N-terminal acetylation is a common protein modification in eukaryotes associated with numerous cellular processes. Inherited mutations in NAA10, encoding the catalytic subunit of the major N-terminal acetylation complex NatA have been associated with diverse, syndromic X-linked recessive disorders, whereas de novo missense mutations have been reported in one male and one female individual with severe intellectual disability but otherwise unspecific phenotypes. Thus, the full genetic and clinical spectrum of NAA10 deficiency is yet to be delineated. We identified three different novel and one known missense mutation in NAA10, de novo in 11 females, and due to maternal…
Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation
2020
Altres ajuts: The group has received funding from 'la Caixa Foundation' CI15-00009, from the European Institute of Innovation and Technology (EIT) PoC-2016-SPAIN-04, which receives support from the European Union's Horizon 2020 research and innovation program, and from the 'Fundación para la Innovación y la Prospectiva en Salud en España (FIPSE)' program 3594-18. Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to interact with the excitotoxicity driver NMDA receptor (NMDAR), and in sudden pathophysiological conditions of the brain, e.g., stroke, several lines of evidence link DAPK1 with t…
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…
2018
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…
Latvijas Universitātes Raksti. 755. sēj.
2010
LogDet divergence-based metric learning with triplet constraints and its applications.
2014
How to select and weigh features has always been a difficult problem in many image processing and pattern recognition applications. A data-dependent distance measure can address this problem to a certain extent, and therefore an accurate and efficient metric learning becomes necessary. In this paper, we propose a LogDet divergence-based metric learning with triplet constraints (LDMLT) approach, which can learn Mahalanobis distance metric accurately and efficiently. First of all, we demonstrate the good properties of triplet constraints and apply it in LogDet divergence-based metric learning model. Then, to deal with high-dimensional data, we apply a compressed representation method to learn…
Vairogdziedzera mezglu malignitātes riska standartizēto novērtēšanas sistēmu salīdzinājums
2020
Vairogdziedzera mezglu malignitātes riska standartizētas novērtēšanas sistēmas (TIRADS) vairogdziedzera ultrasonogrāfijas laikā ir ļoti svarīgas pacientiem ar vairogdziedzera mezgliem, jo tās var palīdzēt izvērtēt tievās adatas aspirācijas biopsijas (FNA) nepieciešamību. Pasaulē ir izveidotas vairākas TIRADS novērtēšanas sistēmas, Latvijā tiek pielietota Kwak et al. 2011. gadā izveidota TIRADS sistēma, tomēr neviena no TIRADS sistēmām nav atzīta par etalonu. Pētījuma mērķis ir izpētīt, kura no trim TIRADS sistēmām ir jutīgāka un precīzāka – Latvijā pielietojamā, Eiropas vai Korejas TIRADS sistēma. Materiāli un metodes: Prospektīvs pētījums, kurā tika analizēti 176 pacientu vairogdziedzeru u…
Vairogdziedzera vēža sastopamība pacientiem ar akromegāliju
2016
Akromegālija ir reta endokrīna saslimšana, kas raksturojas ar paaugstinātu STH un IGF-1 sekrēciju. Zināms, ka akromegālijas slimniekiem ir paaugstināts audzēju risks. 54-65% akromegālijas pacientiem ir nodoza struma. Pēc literatūras datiem 5-10% mezglu ir maligni, kas liek domāt, ka arī vairogdziedzera vēža risks akromegālijas pacientiem ir lielāks. Literatūrā ir dažādi pētījumi, kuros ir minēta cukura diabēta (CD) saistība ar audzējiem. Glikozes regulācijas traucējumi ir bieža akromegālijas blakus slimība un ir maz pētījumu par to lomu vairogdziedzera patoloģiju attīstībā. Vēl joprojām akromegālijas pacientiem tiek pētīti iespējamie audzēju attīstības mehānismi. Pētījuma mērķis ir noskaidr…
Adequate Training and Multidisciplinary Support May Assist Pediatricians in Properly Handling and Managing Gender Incongruence and Dysphoria.
2022
What we call “sexual identity” refers to the complex relationship between biological sex, gender identity and role, and sexual orientation.1 “Gender identity” means the unified and persistent perception of oneself as belonging to the male or the female gender or ambivalent. For many, gender identity coincides with sexual identity; traditional culture has long provided for the definition of only 2 genders, corresponding to the 2 biological sexes. The person with gender incongruence experiences a disharmony between biological aspects and gender identity, with the constant awareness that he or she belongs to the opposite gender and is imprisoned in a body that does not represent him or her. Ge…
EU-TIRADS salīdzinājums ar Latvijā izmantoto modificēto TIRAD sistēmu vairogdziedzera mezglu malignitātes riska novērtēšanai
2019
TIRADS ir vairogdziedzera mezglu malignitātes riska novērtēšanas sistēma, kuras galvenie mērķi ir atvieglot endokrinologu un radiologu – diagnostu darbu, palīdzot atlasīt pacientus tālākai vairogdziedzera mezglu punkcijas biopsijas veikšanai, kas mūsdienās ir objektīvākā metode varogdziedzera mezglu malignitātes apstiprināšanai. Pastāv vairāki TIRADS modeļi, no kurām Latvijā tika izmantota 2011.gada modificēta sistēma. Pētījuma mērķis bija noskaidrot un salīdzināt galvenās atšķirības starp vairogdziedzera US klašu interpretāciju, kā arī malignitātes riska atšķirības Eiropā un Latvijā izmantotajās TIRAD sistēmās. Petījuma gaitā tika izvirzīta hipotēze, ka vairogdziedzera mezgliem, kuri lokal…
Invariant circles in the Bogdanov-Takens bifurcation for diffeomorphisms
1996
AbstractWe study a generic, real analytic unfolding of a planar diffeomorphism having a fixed point with unipotent linear part. In the analogue for vector fields an open parameter domain is known to exist, with a unique limit cycle. This domain is bounded by curves corresponding to a Hopf bifurcation and to a homoclinic connection. In the present case of analytic diffeomorphisms, a similar domain is shown to exist, with a normally hyperbolic invariant circle. It follows that all the ‘interesting’ dynamics, concerning the destruction of the invariant circle and the transition to trivial dynamics by the creation and death of homoclinic points, takes place in an exponentially small part of the…