Search results for "Ofili"
showing 10 items of 996 documents
Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
2014
The EU FP6 project carcinoGENOMICS explored the combination of toxicogenomics and in vitro cell culture models for identifying organotypical genotoxic- and non-genotoxic carcinogen- specific gene signatures. Here the performance of its gene classifier, derived from exposure of metabolically competent human HepaRG cells to prototypical non-carcinogens (10 compounds) and hepatocarcinogens (20 compounds), is reported. Analysis of the data at the gene and the pathway level by using independent biostatistical approaches showed a distinct separation of genotoxic from non-genotoxic hepatocarcinogens and non-carcinogens (up to 88 % correct prediction). The most characteristic pathway responding to …
The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value
2021
AbstractIron is a fundamental nutrient utilized by living cells to support several key cellular processes. Despite its paramount role to sustain cell survival, excess of labile iron availability can inflict severe cell damage via reactive oxygen species generation which, in turn, can promote neoplastic transformation. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tensions herein present. Moreover, cigarette smoke as well as air pollution particulate can function as vehicles of iron supply, leading to an iron dysregulation condition shown to be crucial in the pathogenesis of several respiratory diseases including lung cancer. Hephaestin (HEPH) bel…
Vadības, uzmanības funkciju un apstrādes ātruma spēju heterogenitāte bērniem ar un bez UDHS
2022
Pētījuma mērķis bija izpētīt vadības, uzmanības funkciju un informācijas ātruma spēju heterogenitāti bērniem ar un bez UDHS. Kā arī noskaidrot vai pastāv statistiski nozīmīgas atšķirības šajās spējās starp abām grupām. Pētījumā piedalījās 76 bērni vecumā no 8-13 gadiem, kas tika sadalīti divās grupās: UDHS grupā - 46 bērni (M = 10,08; SD = 1,67), kontroles grupā – 30 bērni (M = 9,41; SD = 1,60). Lai aprēķinātu kognitīvo spēju rādītājus, tika izmantotas četras metodes: Strūpa vārdu un krāsu tests, Simbolu šifrēšanas tests, Ciparu atmiņas tests un Nepārtrauktās veiktspējas tests. Pētījuma rezultāti tikai daļēji atklāj nozīmīgas atšķirības starp grupām – kavēšanas kontroles traucējumu rādītājo…
Factores predictores de respuesta a los tratamientos de inmunotolerancia en pacientes hemofílicos A con inhibidores
2015
En el momento actual se considera que la aparición de inhibidores tras la administración de concentrados del factor deficitario es la complicación más seria y que condiciona en mayor medida el tratamiento y la calidad de vida de los hemofílicos. Este problema es mucho más frecuente en hemofilia A grave (21-33%). El objetivo terapéutico a largo plazo es la erradicación del inhibidor mediante los tratamientos de inducción de tolerancia inmunológica (ITI). En este trabajo se presentan los resultados de los ITI llevados a cabo en una unidad de referencia en coagulopatías. Se trata de un estudio retrospectivo y prospectivo de los tratamientos efectuados entre 1980 y 2015. En este periodo se trat…
Personalizētas mācīšanās iespējas 3.klases skolēniem caurviju prasmju kontekstā
2022
Šobrīd skolās ir novērojamas situācijas, kurās ne vienmēr skolēnam ir iespēja mācību procesa gaitā parādīt sevi un atklāt savas prasmes vai spējas, kas turklāt rada neveselīgu uzskatu par mācīšanos. Ne vienmēr mācību procesā tiek ņemtas vērā skolēna intereses, tādēļ darba autore uzsver, ka šīs mācību problēmas būtu novēršamas, ja mācību procesu vairāk balstītu uz personalizētas mācīšanās teorētiskām nostādnēm. Bakalaura darbs “Personalizētas mācīšanās iespējas 3.klases skolēniem caurviju prasmju kontekstā.” Sastāv no 2 nodaļām un 5 apakšnodaļām secinājumiem, izmantotās literatūras un avotu saraksta un pielikumiem. Lai veiktu pētījumu par bakalaura darba tēmu “Personalizētas mācīšanās iespēj…
The transformation of the Horatian Sabine farm in Persius? Satire 6
2020
The purpose of this article is to focus on the motif of the countryside in Roman satire. In particular, it aspires to study the way the Sabine farm is delineated in Horace's Satire 2.6 and later in his Epistles, in order to elucidate the evolution of this motif in Persius? 6th Satire. In this poem, Persius addresses Caesius Bassus, who retreats to Sabine to seek poetic inspiration, but seems trapped in the paths of earlier poetry and cannot attain bliss, while the poet achieves it in the port of Luna.
The transcriptome analysis of Strongyloides stercoralis L3i larvae reveals targets for intervention in a neglected disease.
2012
Background: Strongyloidiasis is one of the most neglected diseases distributed worldwide with endemic areas in developed countries, where chronic infections are life threatening. Despite its impact, very little is known about the molecular biology of the parasite involved and its interplay with its hosts. Next generation sequencing technologies now provide unique opportunities to rapidly address these questions. Principal Findings: Here we present the first transcriptome of the third larval stage of S. stercoralis using 454 sequencing coupled with semi-automated bioinformatic analyses. 253,266 raw sequence reads were assembled into 11,250 contiguous sequences, most of which were novel. 8037…
Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs.
2018
Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)a and IFN? and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activit…
IFI16 expression is related to selected transcription factors during B-cell differentiation
2015
The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation.IFI16mRNA was differentially expressed in B-cell subsets with significant decrease inIFI16mRNA in GC and PCs with respect to naïve and memory subs…
Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology
2019
Recent advances in cytometry have radically altered the fate of single-cell proteomics by allowing a more accurate understanding of complex biological systems. Mass cytometry (CyTOF) provides simultaneous single-cell measurements that are crucial to understand cellular heterogeneity and identify novel cellular subsets. High-dimensional CyTOF data were traditionally analyzed by gating on bivariate dot plots, which are not only laborious given the quadratic increase of complexity with dimension but are also biased through manual gating. This review aims to discuss the impact of new analysis techniques for in-depths insights into the dynamics of immune regulation obtained from static snapshot …