Search results for "Oral presentation"
showing 10 items of 22 documents
Increased percentages of calprotectin and TNF-Α double-positive monocytes in the acute phase of Kawasaki disease
2011
Background The acute phase of KD is characterized by a deficiency of suppressor T cells, marked activation of the immune system and increased secretion of cytokines by immune effector cells. Moreover, it has been shown that myeloid-related protein (MRP-8 and MRP-14) and S100proteins, the major calcium-binding proteins secreted by activated neutrophils and monocytes, contribute to cause inflammation in acute lesions of KD, and indeed one of the more common hematological alteration in KD is the increase of peripheral blood monocytes. Calprotectin, one of the major calcium-binding proteins, can lead to direct and indirect effects that result not only in inflammation but also in modification of…
cGMP modulates stem cells differentiation to neurons in brain in vivo pathological implications
2011
During brain development there is a strict control of the proliferation, migration and differentiation of neural stem cells to different cell types. Alterations in the control of these processes may result in altered balance in the formation of different cell types resulting in a long-lasting impairment of cerebral processes. This occurs for example if brain is exposed to alcohol during key stages of development which results in accelerated glial cells formation, impaired neuron formation and impaired cognitive function. The molecular mechanisms modulating differentiation of neural stem cells to neurons or non neuronal cells are not well known. Nitric oxide (NO) plays a relevant role in thi…
Gene-based treatment options for Usher type 1C by translational read-through of a nonsense mutation
2012
The Usher syndrome (USH) is the most frequent cause of inherited combined deaf-blindness. The ciliopathy is clinically and genetically heterogeneous, assigned to three clinical USH types of which the most severe type is USH1. The USH1C gene encodes the PDZ containing scaffold protein harmonin which is expressed in form of numerous alternatively spliced variants. Hamonin binds directly to all USH1/2 proteins and is a key organizer of USH protein networks in photoreceptor cells. So far no effective treatment for the ophthalmic component of USH exists. Translational read-through was introduced as an innovative therapy option for several non-ocular diseases caused by nonsense mutations leading …
150 years of rowing faster: what are the sources of more and more speed?
2015
Rowing has a 150 yr+ competitive history. Examining results from historic races like Oxford-Cambridge (established 1829) and the world championships (established 1893) reveals a linear increase in boat speed by 2-3% per decade. Boat velocity increases if propulsive power is increased and/or power losses are reduced. Over time, the propulsive power capacity of elite rowers has increased. Part of this increase is a result of recruiting athletes from a population that has become taller (1-3 cm per decade) and heavier. Modern world class rowers are typically 190-200 cm tall and weigh 90-100 kg. However, physical capacity does not scale directly with body dimensions but conforms instead to biolo…
O047. The sound-induced flash illusions reveal visual cortex hyperexcitability in cluster headache
2015
Objectives Pathophysiology of cluster headache (CH) is not wellknown. Although posterior hypothalamus has been suggested to play a pivotal role, evidence exists of a more diffuse involvement of the central nervous system including brainstem and cerebral cortex. In this regard, we recently observed increased motor cortical excitability in episodic CH patients both outside and inside bout [1]. The sound-induced flash illusions (SIFI) represent an example of multisensory integration, and provide a tool to indirectly explore the excitability state of the visual cortex [2]. SIFI are classified as “fission” and “fusion” illusions. When one visual stimulus (flash) is accompanied by two or more aud…
Wpływ mediów na ustne wypowiedzi maturzystów
2017
Artykuł poświęcony jest wpływowi mediów na język młodzieży. Składa się z trzech części, w których kolejno opisuję przeobrażenia polskiego modelu językowego, cechy języka medialnego oraz ich obecność w ustnych wypowiedziach polskich maturzystów.
O046. Color vision and visual cortex excitability are impaired in episodic migraine. Simply coexisting or pathophysiologically related dysfunctions?
2015
Background and objectives Evidence of abnormal color vision processing in migraine comes from observation of positive symptoms during visual aura, effects of strong color contrast triggering attacks and of colored-spectacles reducing migraine frequency. Although the central or peripheral basis of such color misperception remains unclear, several authors reported a selective deficit of shortwavelength cones (S-cones) [1]. Sound-induced flash illusions (SIFI) are a simple way to describe visual distorsion induced by acoustic perception. SIFI critically depend on excitability of primary visual cortex (V1) as they are reduced by facilitatory anodal transcranial direct current stimulation (tDCS)…
O069. Menstrual cycle affects cortical excitability differently in females with migraine and in healthy controls: a new perspective by cross modal so…
2015
The sound-induced flash illusions (SIFI) represent a valid tool to explore multimodal perception and are critically dependent on visual and acoustic cortical excitability [1, 2]. In a previous study [3], we observed a significant reduction of illusions in migraine patients with respect to healthy controls, probably due to a condition of visual cortex hyperexcitability. Aim of the present study was to evaluate SIFI perceptions in healthy women and patients with menstrual migraine and to describe the effects of cyclical change of steroid hormones and cortical responsiveness.
Some epidemiological aspects of nosocomial infections. Antibiotic sensitivity rates of isolated bacteria from nosocomial infections - A prospective s…
2014
Results The total number of isolated strains was 413, 231 in 2012 and 182 in 2013. In the intensive care units 151 nosocomial infections were identified; 88 strains in the Surgical Department, 27 strains in the Department of Gynecology and Obstetrics, 24 strains in the Department of Neurosurgery and 23 in the Orthopedic Department. 19 strains were identified in the Neurology Department and also in the Internal Medicine Department, 17 strains were identified in the Urology Department, 14 in the Aesthetic Surgery Department, 8 in the Nephrology Department, 8 in the Hematology Department and 5 in the Gastroenterology Department. 3 strains were isolated in each of the following departments: Dia…
TRANS-FUSIMO - clinical translation of patient specific planning and conduction of FUS treatment in moving organs
2015
The movement of the target challenges the application of high intensive focused ultrasound (HiFU/MRgFUS) for the treatment of malignancies in moving abdominal organs such as liver and kidney. Moreover, the anatomical location of the lesion is often behind the rib cage. The physiology of the organs, the dynamic and complex blood perfusion impairs the energy disposition in the tissue due to the heat transfer within the organ. To explore the full potential of extracorporeal FUS to safely and precisely destroy tissue in the depth of a moving organ requires sophisticated software and advanced hardware. In the EU project FUSIMO (http://www.fusimo.eu) a software demonstrator for the patient specif…