Search results for "Oxyquinoline"
showing 10 items of 17 documents
CCDC 633848: Experimental Crystal Structure Determination
2007
Related Article: M.Albrecht, Triyanti, S.Schiffers, O.Osetska, G.Raabe, T.Wieland, L.Russo, K.Rissanen|2007|Eur.J.Org.Chem.|2007|2850|doi:10.1002/ejoc.200700130
8-Hydroxyquinoline-2-Carboxylic Acid as Possible Molybdophore: A Multi-Technique Approach to Define Its Chemical Speciation, Coordination and Sequest…
2020
8-hydroxyquinoline-2-carboxylic acid (8-HQA) has been found in high concentrations (0.5&ndash
Zinc(II) complexes of amide- and urea-substituted 8-hydroxyquinolines
2002
Abstract A series of amide- and urea-substituted 8-hydroxyquinoline ligands 1–6-H are used for the formation of zinc(II) complexes. Hereby in general 2:1 complexes are obtained and the X-ray structure of [(3)2Zn] reveals the presence of a coordination polymer in the solid state. Only the derivatives of 7-amino-8-hydroxyquinoline 4-H and 5-H form trinuclear hexa-helical 6:3 complexes which exhibit interesting structural and NMR and fluorescence spectroscopic properties.
The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study.
1997
The mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in Salmonella typhimurium TA98 is inhibited by flavonoids with distinct structure-antimutagenicity relationships (Edenharder, R., I. von Petersdorff I. and R. Rauscher (1993). Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food, Mutation Res., 287, 261-274). With respect to the mechanism(s) of antimutagenicity, the following results were obtained here. (1) 7-Methoxy- and 7-ethoxyresorufin-O-dealkylase activities in rat liver microsomes, linked to cytochrome P-450-dependent 1A1 and…
Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity …
2009
International audience; Three series of 1-substituted-7-chloro-6-hydroxy-tetrahydroisoquinolines (1-butyl-, 1-phenyl- and 1-benzyl derivatives) were prepared to explore the influence of each of these groups at the 1-position on the affinity for dopamine receptors. All the compounds displayed affinity for D(1)-like and/or D(2)-like dopamine receptors in striatal membranes, and were unable to inhibit [(3)H]-dopamine uptake in striatal synaptosomes. Different structure requirements have been observed for adequate D(1) or D(2) affinities. This paper details the synthesis, structural elucidation, dopaminergic binding assays, structure-activity relationships (SAR) of these three series of isoquin…
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system
2007
A series of substituted derivatives containing the 1,4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity. Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen. Compound 17 was the most outstanding derivative because of its remarkable in vivo anti-inflammatory activity. In this paper, we examine and discuss the structure-activity relationships and anti-inflammatory activiti…
Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analyse…
2014
The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident probiotic bacteria during infection treatment, the use of molecules with selective antibacterial activity enhances the efficacy by selectively removing C. difficile. One of them is the plant alkaloid 8-hydroxyquinoline (8HQ), which has been shown to selectively inhibit clostridia without repressing bifidobacteria. Selective antimicrobial activity is generally tested by culture techniques of individual bacterial strains. However, the main limitation of these techniques is the inability to describe …
Gelation behavior of 5-chloro-8-hydroxyquinoline, an antituberculosis agent, in aqueous alcohol solutions
2012
It was shown that 5-chloro-8-hydroxyquinoline, an antituberculosis agent, gels aqueous alcohol solutions efficiently. Thermal stability and gel-to-sol transition temperature of 1% gel in CD3OD/D2O (2:1) was studied by 1H-NMR. Fibrous structures of four xerogels have been characterized by scanning electron microscope. peerReviewed
CCDC 133179: Experimental Crystal Structure Determination
2003
Related Article: M.Albrecht, K.Witt, E.Wegelius, K.Rissanen|2000|Tetrahedron|56|591|doi:10.1016/S0040-4020(99)01057-1
CCDC 633849: Experimental Crystal Structure Determination
2007
Related Article: M.Albrecht, Triyanti, S.Schiffers, O.Osetska, G.Raabe, T.Wieland, L.Russo, K.Rissanen|2007|Eur.J.Org.Chem.|2007|2850|doi:10.1002/ejoc.200700130