Search results for "PANA"
showing 10 items of 193 documents
Looking for a new panacea in ALK-rearranged NSCLC: may be Ceritinib?
2014
Abstract: In the past decade, the advent of targeted therapy led to a silent revolution in the war against lung cancer and a significant evolution on the concept of Phase I clinical trials design. Thanks to the specificity of their target, the new drugs have radically changed NSCLC treatment, leading to the development of personalized strategies. The accelerated approval of the first ALK-inhibitor, Crizotinib and more recently Ceritinib, without a Phase III randomized, clinical trial, has been an amazing success story in lung cancer research, marking the beginning of a new decade of targeted drugs development, characterized by modern, biomarker-driven, early clinical trial design and shorte…
First report of Tomato leaf curl Sinaloa virus infecting tomato crops in Panama
2015
In April 2011 and September 2012, virus-like symptoms were observed in open field- and greenhouse-grown tomato crops (Solanum lycopersicum) in Chiriquí, the westernmost province of Panama. Samples from symptom-bearing plants (127 in all) were collected and tested for the presence of begomoviruses by polymerase chain reaction (PCR) assays with sets of degenerated primers designed to amplify parts of the DNA-A and DNA-B components (Rojas et al., 1993; Table 1). Products of the expected sizes, obtained with both DNA-A- and DNA-B-specific primers for 49 samples, suggested infection with New World bipartite begomoviruses. This corresponds to an incidence of 26% (8 plants) in open field, and 43% …
Panaxie
2009
Prefazione al volume di poesie, Panaxie, di Angelo Giambartino
Chemical Composition of the Essential Oils of Three Species of Apiaceae Growing Wild in Sicily: Bonannia graeca, Eryngium maritimum and Opopanax chir…
2013
In the present study the chemical composition of the essential oils from aerial parts of Bonannia graeca (L.) Halácsy and Opopanax chironium (L.) Kock, and from aerial parts and roots of Eryngium maritimum L. was evaluated by GC and GC-MS. α-Pinene (15.2%) and β-pinene were recognized as the main constituents of B. graeca, whereas the aerial parts of O. chironium contained mainly the diterpene cembrene and the coumarin angelicin. In both aerial parts and roots of E. maritimum germacrene D (10.4% and 15.9%, respectively) and 2,4,5-trimethylbenzaldehyde (8.3% and 6.7%) were the most abundant components.
Scaling laws in the distribution of galaxies
2004
Research done during the previous century established our Standard Cosmological Model. There are many details still to be filled in, but few would seriously doubt the basic premise. Past surveys have revealed that the large-scale distribution of galaxies in the Universe is far from random: it is highly structured over a vast range of scales. To describe cosmic structures, we need to build mathematically quantifiable descriptions of structure. Identifying where scaling laws apply and the nature of those scaling laws is an important part of understanding which physical mechanisms have been responsible for the organization of clusters, superclusters of galaxies and the voids between them. Find…
Una nueva forma de hacer política: dar la voz a la militancia ¿realidad o mera apariencia?
2020
Political parties have been accused of being controlled by an elite or caste that has looked more for their own interests than for general interests. A new way of doing politics and new parties has appeared whose stated objective has been to return the voice to the militancy, assuming that it had been kidnapped by the inbreeding elites of the parties. This paper analyses whether the parties, whose power has traditionally been built from top to bottom, have assumed this change that would mean that power flows from the bottom up or has simply taken a cosmetic operation that apparently responds to this new way of doing policy, although the power is still in the hands of a minority. Summary:1. …
Tourism planning and innovation: The Caribbean under the spotlight
2018
International audience; The importance of the islands working together toward a multicentre product for tourists has been highlighted asearly as the 1980s, and yet hardly anything has been done in that sense. Can cluster be considered as the wayforward for the sustainable development of the Caribbean? This question could be considered as the first step ofthe tourism planning process. Hierarchical method or linkage method that works by identifying entities thatmatch each other based on the investigator selection of similar attribute categories is the most suitable clusteringapproach for the Caribbean. Despite the fact that cluster appears as a potential solution for issues faced by someCarib…
Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods
2021
The selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune, inflammatory diseases, and hematologic malignancies. Recently, a new series of amide derivatives as non-covalent inhibitors of the β1i subunit with Ki values in the low/submicromolar ranges have been identified. Here, we investigated the binding mechanism of the most potent and selective inhibitor, N-benzyl-2-(2-oxopyridin-1(2H)-yl)propanamide (1), to elucidate the steps from the ligand entrance into the binding pocket to the ligand-induced conformational changes. We carried out a total of 400 ns of MD-binding analyses, followed by 200 ns of plain MD. The trajectories clustering allowed identifying thre…
Tropomyosin: A panallergen that causes a worldwide allergic problem
2021
Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symp…
Trabajo feminino y distribucion de rentas en Espana
1988
International audience; En este artículo detallamos la actividad profesional de las mujeres casadas, y medimos, a lo largo del ciclo de vida de los hogares, el impacto del trabajo femenino sobre la distribución de las rentas familiares. A continuación, confrontamos la situación de España con la de otros paises donde han podido efectuarse análisis similares ^Francia, Gran gretaña y Estados Unidos).