Search results for "PAP"
showing 10 items of 3248 documents
European society of hypertension position paper on ambulatory blood pressure monitoring
2013
Ambulatory blood pressure monitoring (ABPM) is being used increasingly in both clinical practice and hypertension research. Although there are many guidelines that emphasize the indications for ABPM, there is no comprehensive guideline dealing with all aspects of the technique. It was agreed at a consensus meeting on ABPM in Milan in 2011 that the 34 attendees should prepare a comprehensive position paper on the scientific evidence for ABPM.This position paper considers the historical background, the advantages and limitations of ABPM, the threshold levels for practice, and the cost-effectiveness of the technique. It examines the need for selecting an appropriate device, the accuracy of dev…
Enhancer trap infidelity in Drosophila optomotor-blind
2013
Reporter gene activity in enhancer trap lines is often implicitly assumed to mirror quite faithfully the endogenous expression of the "trapped" gene, even though there are numerous examples of enhancer trap infidelity. optomotor-blind (omb) is a 160 kb gene in which 16 independent P-element enhancer trap insertions of three different types have been mapped in a range of more than 60 kb. We have determined the expression pattern of these elements in wing, eye-antennal and leg imaginal discs as well as in the pupal tergites. We noted that one pGawB insertion (omb (P4) ) selectively failed to report parts of the omb pattern even though the missing pattern elements were apparent in all other 15…
A White Paper on keV sterile neutrino Dark Matter
2017
We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, and particle physics - in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrin…
Thermal sensation and cell adaptability
2013
Whole person adaptive comfort is discussed with reference to recent findings in molecular scale systems biology. The observations are upscaled to hypotheses relating to less traditional interpretations of thermal processes, which have new implications for indoor climate management and design. Arguments are presented for a revision of current focus, model and paradigm. The issue is seen as a problem of integrating theoretical development, conceptual modeling and as an investigation of the extent to which environments and acclimatization can be used to achieve individual fitness and health, not only at the subjective comfort level, as hitherto promoted. It is argued that there are many questi…
Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts
1984
Quinidine exerts anticholinergic effects which have been ascribed to atropine-like properties of the drug. We have examined the effects of acetylcholine on the force of contraction in isolated heart muscle preparations from cats and compared the inhibitory effects of atropine with those of quinidine. The effects of acetylcholine were antagonized competitively in the presence of atropine. The Schild-plot yielded a straight line; the slope was not significantly different from unity. In the presence of quinidine, the concentration-response curve of acetylcholine was shifted to the right as with atropine, however, the Schild-plot yielded a regression line which was not linear; the slope was sta…
Apmaksāta un neapmaksāta atvaļinājuma tiesiskais regulējums un tā piemērošanas aktualitātes.
2021
Darba autore: Santa Orbidāne Darba tēma: Apmaksāta un neapmaksāta atvaļinājuma tiesiskais regulējums un tā piemērošanas aktualitātes Darba veids: Bakalura darbs Darbs izklāstīts uz 40 lappusēm, ietver 8 tabulas, 20 literatūras avoti. Bakalaura darbā tiek pētīts apmaksāta un neapmaksāta atvaļinājuma tiesiskais regulējums un tā piemērošana. Pētījuma ietvaros, tika aplūkoti atvaļinājuma veidi, to piešķiršana, atlīdzināšana, kā arī darba strīdi. Darba strīdi vienmēr ir aktuāli, bet valstī esošās ārkārtējās situācijas dēļ ir ietekmēti dažādu darba nozaru sfērā strādājošie. Līdz ar to darba mērķis ir izprast, kā rīkoties pareizāk, nepārkāpjot darba ņēmēja tiesības un ko darīt gadījumā, ja šīs tie…
Representation of ASD in mass media: analysis of a generalist newspaper
2020
Los medios de comunicación influyen notablemente en sus consumidores, por lo que no son meros informadores, sino que también son creadores de opinión. Este hecho es relevante para el ámbito de la inclusión, en tanto que las necesidades específicas de apoyo educativo son también un tema tratado por los medios de comunicación. En el presente estudio se analizan los artículos que abordan la temática relacionada con el Trastorno del Espectro Autista (TEA) en el diario El País durante el año 2017. Los resultados del análisis de contenido de los artículos indican que el TEA fue un tema de interés en el año 2017. Los contenidos más recurrentes fueron las causas del TEA, frecuentemente desmintiendo…
Sleep Apnea, Sleepiness, and Driving Risk
2019
Obstructive sleep apnea is associated with excessive daytime sleepiness in about 50% of cases, and with increased risk of driving accidents. Treatment with continuous positive airway pressure effectively decreases such risk, but compliance with continuous positive airway pressure treatment is often suboptimal. According to the European Union Directive on driving risk, retention of a driving license in patients with obstructive sleep apnea requires assessment of sleepiness and adherence to continuous positive airway pressure treatment, but there remains uncertainty on the optimal methods to assess sleepiness on a large scale.
Involvement of PAR-4 in Cannabinoid-Dependent Sensitization of Osteosarcoma Cells to TRAIL-Induced Apoptosis
2014
The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). In treated cells we also observed the conversion of the cytosolic form of the autophagosome marker LC3-I into LC3-II (the lipidated form located on the autophagosome membrane) and the enhanced incorporation of monodansylcadaverine and acridine orange, two markers of t…
Diffusion of Drone Journalism: the Case of Finland, 2011-2020
2020
This article details Finnish news organizations’ adoption of drones for journalistic purposes from 2011 to 2020. The theoretical starting point of the article is Rogers’ (1962) diffusion of innovations theory, which explains how new ideas and technologies spread in societies. The main empirical data for the study were derived from a phone survey conducted among the 80 most popular newspapers in Finland. The findings reveal that drone journalism in Finland has already diffused from a few pioneering organizations to a large number of newsrooms, including regional, mid-sized newspapers. Most of the newspapers are either using in-house drones, buying commissioned images, or using both strategie…