Search results for "PERK"
showing 10 items of 75 documents
Two cases of adynamia episodica hereditaria: In vitro investigation of muscle cell membrane and contraction parameters
1983
Membrane potentials, current-voltage relationships, and contractile parameters were studied in intact muscle cell bundles obtained from two patients with adynamia episodica hereditaria. In a normal extracellular medium, the cell membranes had resting potentials of about -80 mV and their current-voltage relationships were not significantly different from control curves. In contrast to normal muscles the afflicted cells were paralyzed in a medium having 6-10 mmol/liter potassium. The mechanisms of paralysis in the two specimens were different from each other. Many fibers from one patient were spontaneously active even in normal solution. In high potassium solution spontaneous activity was inc…
Activated Cashew Carbon-Manganese Oxide Based Electrodes for Supercapacitor Applications
2023
The current global energy challenge which affects most developing countries in particular, is of major source of concern today. The availability of less expensive techniques of storing excess generated energy is critical to the success of the renewable energy roadmaps implementation. In this study, hydrothermal and chemical leaching methods have been used to synthesize MnO2 nanoparticles using KMnO4 and MnSO4 as precursors at 140 °C and from natural local manganese ore. Activated Carbon (ACF) have also been produced from agricultural Cashew biomass waste, through a physical carbonization and KOH activation process using temperatures of 700 °C – 900 °C for periods between 1-2 hours. The as-p…
Between Scylla and Charibdis: eIF2α kinases as targets for cancer chemotherapy
2011
[EN] The eIF2 alpha kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell biology, ranging from regulation of cell cycle progression, maintenance of genome stability, control of apoptosis, and cell survival under nutrient stress and hypoxia. Accordingly, active eIF2 alpha kinases modulate the antineoplasic activity of several antitumour drugs, either by exacerbating their cytotoxic effect or by promoting chemoresistance. Understanding of eIF2 alpha kinases molecular roles may provide mechanistic insights into how tumour cells sense and adapt to …
Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain
2007
Elevated brain glutamate with activation of neuronal glutamate receptors accompanies neurological disorders, such as epilepsy and brain trauma. However, the mechanisms by which excitotoxicity triggers neuronal injury are not fully understood. We have studied the glutamate receptor agonist kainic acid (KA) inducing seizures and excitotoxic cell death. KA caused the disintegration of the endoplasmic reticulum (ER) membrane in hippocampal neurons and ER stress with the activation of the ER proteins Bip, Chop, and caspase-12. Salubrinal, inhibiting eIF2α (eukaryotic translation initiation factor 2 subunit α) dephosphorylation, significantly reduced KA-induced ER stress and neuronal deathin vivo…
Ureteru akmeņu endoskopiskās ārstēšanas iespējas
2016
Ievads: Urīnakmeņu incidence pasaulē ir 1500-2000 gadījumi uz miljonu iedzīvotāju. Pēc statistikas datiem nierakmeņu izplatības rādītāji svārstās no 1% līdz 20%. Šī slimība ir novērojama pacientiem pārsvarā no 30 līdz 50 gadu vecumā. Pēc Eiropas Urologu asociācijas 2012. gada datiem nierakmeņu slimību sastop aptuveni 20% gadījumu no visām uroloģiskajām saslimšanām. Materiāli un metodes: Retrospektīvā pētījumā tika iekļauti 123 pacienti ar urolitiāzi, kuri ārstējās Paula Stradiņa klīniskā universitātes slimnīcā 4. uroloģijas nodaļā laika posmā no 2013. gada 1. janvāra līdz 2014. gada 31. decembrim. Tiek ievākti un analizēti sekojošie pacientu dati: pētījumu objekta skaits; vecums un to dzimu…
IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions
2014
The lack of a generally accepted animal model for human psoriasis has hindered progress with respect to understanding the pathogenesis of the disease. Here we present a model in which transgenic IL-17A expression is targeted to the skin in mice, achievable after crossing our IL-17A(ind) allele to the K14-Cre strain. K14-IL-17A(ind/+) mice invariably develop an overt skin inflammation bearing many hallmark characteristics of human psoriasis including dermal infiltration of effector T cells, formation of neutrophil microabscesses, and hyperkeratosis. IL-17A expression in the skin results in upregulated granulopoiesis and migration of IL-6R-expressing neutrophils into the skin. Neutralization …
Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection.
2005
Purpose To analyze proliferative verrucous leukoplakia (PVL) for the presence of human papillomavirus (HPV) in different stages of the disease. Materials and Methods We studied 13 patients with PVL. In 10 patients (76.9%), a lesional biopsy was taken and frozen at −40°C. Four patients were instructed to mouth rinse with sterile sera. The biopsy and rinse samples were analyzed for HPV by PCR. Results We did not detect HPV infection in the PVL tissue or in the oral rinse of any of the 13 patients in any stage of the disease analyzed, neither in oral squamous cell carcinoma nor in the simple hyperkeratosis. Conclusion There was no association between PVL and HPV infection in our patients.
5-6 gadīgu bērnu perkusīvo mūzikas instrumentu spēles apguve attālinātās mācībās pirmsskolā
2021
Maģistra darbs “5-6 gadīgu bērnu perkusīvo mūzikas instrumentu spēles apguve attālinātās mācībās pirmsskolā” tika izstrādāts ar mērķi noskaidrot kā pilnvērtīgi ir iespējams īstenot perkusīvo mūzikas instrumentu spēles apguvi, 5-6 gadus veciem bērniem, mācoties attālināti pirmsskolā. Teorētiskās literatūras un dokumentu analīzes rezultātā tika iegūta padziļināta izpratne par attālinātām mācībām pirmsskolā, kā arī par to kā notiek perkusīvo mūzikas instrumentu spēles apguve 5-6 gadus veciem bērniem. Maģistra darba empīriskajā daļā tika analizētas pirmsskolas mūzikas skolotāju anketaptaujā sniegtās atbildes par attālinātu 5-6 gadīgu bērnu perkusīvo mūzikas instrumentu spēles pilnveidošanu un v…
Il pedone, dal viadotto alle greenway. Figure architettoniche del suolo per camminare in città, 1960-2015
2022
L’articolo traccia un quadro nel quale le fasi successive dell’architettura della città europea del Novecento si leggono attraverso il rapporto fra il pedone e la strada, e pone l’ipotesi che la condizione contemporanea di tale rapporto sia l’aggiornamento di un tema indicatore dell’evoluzione del ruolo della maglia viaria. Come ogni strada, la via pedonale è un’infrastruttura, in cui interagiscono l’idea di progresso, i modi di fabbricazione e consumo degli spazi urbani, nuovi orizzonti politici e di investimento economico, e che rinvia ad immaginari collettivi. A partire dall’inizio della pedonalizzazione, nei primi anni Sessanta, l’articolo discute in un’ottica comparativa e genealogica …
Papillon- Lefevre Syndrome: Report of a case and its management
2012
Papillon-Lefèvre Syndrome (PLS) is a rare autosomal recessive disorder first described by two French physicians, Papillon and Lefèvre in 1924. The disorder is characterized by diffuse palmoplantar keratoderma and precocious aggressively progressing periodontitis, leading to the premature loss of deciduous and permanent teeth at a very young age. The cutaneous lesions are usually manifested simultaneously with the intra-oral presentations and include keratotic plaques on the palms and soles varying from mild psoriasiform scaly skin to overt hyperkeratosis. The etiopathogenesis of the syndrome is relatively obscure and immunologic, genetic or possible bacterial etiologies have been proposed. …