Search results for "PLASMA"
showing 10 items of 4043 documents
Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer
2020
MicroRNAs have emerged as new diagnostic and therapeutic biomarkers for breast cancer. Herein, we analysed miR-99a-5p expression levels in primary tumours and plasma of breast cancer patients to evaluate its usefulness as a minimally invasive diagnostic biomarker. MiR-99a-5p expression levels were determined by quantitative real-time PCR in three independent cohorts of patients: (I) Discovery cohort: breast cancer tissues (n = 103) and healthy breast tissues (n = 26)
Wet BNP, fluid and hemodynamic status at discharge in Acute Heart Failure
2010
We comment the noteworthy results of Pimenta et al. concerning the significance of discharge BNP levels in acute HF patients. The innovation of Pimento's study is the systematic research of the potential relationship between BNP and clinical and hemodynamic parameters. We focused the attention on the importance of wet "BNP" in managing HF and its ability to reflect congestion and multiple underlying patho-physiological disturbances. The first observation, regarding the statistical order, underlines the importance of renal insufficiency at discharge in genesis of higher BNP levels. Secondly, we note that the relationship between natriuretic peptides and the non-invasive measurement of the fl…
P4570Prognostic interest of HbA1c and plasma glucose assessment on one-year mortality in non-diabetic patients after acute myocardial infarction
2019
Abstract Background The usefulness of the combined assessment of HbA1c and plasma glucose (PG) in acute myocardial infarction (AMI) in nondiabetic patients remains unclear. Purpose In a large observational study, we aimed to identify the prognostic values of these biomarkers regarding one-year all-cause mortality in nondiabetic patients after AMI. Methods From the “obseRvatoire des Infarctus de Côte d'Or” (RICO) survey database, we included all consecutive nondiabetic patients with AMI (n=6617) from May 2001 to December 2016. Exclusion criteria were: admission known or unknown diabetes, in-hospital death. The primary endpoint was all-cause one-year mortality. The secondary endpoints were: M…
Kinetic Interaction of Cold and Hot Protons With an Oblique EMIC Wave Near the Dayside Reconnecting Magnetopause
2021
STR acknowledges support from the ISSI international team Cold plasma of ionospheric origin in the Earth's magnetosphere and of the Ministry of Economy and Competitiveness (MINECO) of Spain (grant FIS2017-90102-R). Research at IRAP was supported by CNRS, CNES and the University of Toulouse. JHL and DLT acknowledge support from NASA Grant 80NSSC18K1378. RED was supported by NASA grants 80NSSC19K070 and 80NSSC19K0254. MA was supported by SNSA Grant 56/18. SKV and RCA acknowledge support from NASA Grant 80NSSC19K0270. Work performed by MMS team members is supported by NASA contract NNG04EB99C.
Light absorption and conversion in solar cell based on Si:O alloy
2013
Thin film Si:O alloys have been grown by plasma enhanced chemical vapor deposition, as intrinsic or highly doped (1 to 5 at. % of B or P dopant) layers. UV-visible/near-infrared spectroscopy revealed a great dependence of the absorption coefficient and of the optical gap (Eg) on the dopant type and concentration, as Eg decreases from 2.1 to 1.9 eV, for the intrinsic or highly p-doped sample, respectively. Thermal annealing up to 400 °C induces a huge H out-diffusion which causes a dramatic absorption increase and a reduction of Eg, down to less than 1.8 eV. A prototypal solar cell has been fabricated using a 400 nm thick, p-i-n structure made of Si:O alloy embedded within flat transparent c…
Neuroprotective Potential of GDF11: Myth or Reality?
2019
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.
The Peregrine soliton in nonlinear fibre optics
2010
International audience; The Peregrine soliton is a localized nonlinear structure predicted to exist over 25 years ago, but not so far experimentally observed in any physical system. It is of fundamental significance because it is localized in both time and space, and because it defines the limit of a wide class of solutions to the nonlinear Schrödinger equation (NLSE). Here, we use an analytic description of NLSE breather propagation to implement experiments in optical fibre generating femtosecond pulses with strong temporal and spatial localization, and near-ideal temporal Peregrine soliton characteristics. In showing that Peregrine soliton characteristics appear with initial conditions th…
Smart structures through nontraditional design of Tuned Mass Damper Inerter for higher control of base isolated systems
2020
Abstract This paper introduces a smart structure design through the definition of an innovative passive control strategy, referred to as New Tuned Mass Damper Inerter (New TMDI), coupled with a base isolation system (BI), to control displacements in base isolated structures under seismic excitations. The herein proposed New TMDI comprises a recently developed nontraditional Tuned Mass Damper (known as New TMD), in which a secondary mass system is connected to the base plate of the BI system by a spring and to the ground by a dashpot, and of an inerter device placed in parallel with the damper. An optimization procedure which minimizes the base displacement variance of the BI system, conside…
Determination of a pre-heating sequence for the DONES Target Assembly
2021
Abstract Within the activities promoted by the EUROfusion consortium in support of the design and construction of the DEMO Oriented NEutron Source (DONES), a mock-up of its Target Assembly (TA), based on the configuration with a “bayonet” Back-Plate (BP) and available at ENEA Brasimone labs, is being adopted for the execution of experimental activities aiming at the validation of specific aspects of the target design. Despite the “integral”-TA concept is the current reference, experimental tests concerning the TA pre-heating phase are not significantly affected by the TA concept and are still representative even though conducted on the bayonet-TA concept. Indeed, the main objective of the p…
Quantification of rifampicin and rifabutin in plasma of tuberculosis patients by micellar liquid chromatography
2020
A Micellar Liquid Chromatographic method is described to determine Rifampicin and Rifabutin in plasma from Tuberculosis patients. Samples were diluted in mobile phase and then directly injected, avoiding long and tedious extraction steps. The analytes were resolved from the matrix without interferences from endogenous compounds using a mobile phase of sodium dodecyl sulfate 0.15 mol L-1–6%(v/v) 1-pentanol and phosphate buffer at pH 3, running at 1 mL min−1 through a C18 column at 25 °C. Detection was carried out by UV absorbance at 270 nm. Under these conditions, the final chromatographic analysis time was 22 min. The analytical methodology was validated following the FDA 2018 Bioanalytical…