Search results for "POROSITY"
showing 10 items of 599 documents
Hydration dependent dynamics in sol-gel encapsulated myoglobin.
2008
In this work we study the effect of hydration on the dynamics of a protein in confined geometry, i.e. encapsulated in a porous silica matrix. Using elastic neutron scattering we investigate the temperature dependence of the mean square displacements of non-exchangeable hydrogen atoms of sol-gel encapsulated met-myoglobin. The study is extended to samples at 0.2, 0.3 and 0.5 g water/g protein fractions and comparison is made with met-myoglobin powders at the same average hydration and with a dry powder sample. Elastic data are analysed using a model of dynamical heterogeneity to take into account deviations of elastic intensity from gaussian behaviour in a large momentum transfer range and r…
2020
Abstract. Fluid flow on different scales is of interest for several Earth science disciplines like petrophysics, hydrogeology and volcanology. To parameterize fluid flow in large-scale numerical simulations (e.g. groundwater and volcanic systems), flow properties on the microscale need to be considered. For this purpose experimental and numerical investigations of flow through porous media over a wide range of porosities are necessary. In the present study we sinter glass bead media with various porosities and measure the permeability experimentally. The microstructure, namely effective porosity and effective specific surface, is investigated using image processing. We determine flow proper…
Combined numerical and experimental study of microstructure and permeability in porous granular media
2020
<div> <div> <div> <p>Fluid flow on different scales is of interest for several Earth science disciplines like petrophysics, hydrogeology and volcanology. To parameterize fluid flow in large-scale numerical simulations (e.g. groundwater and volcanic systems), flow properties on the microscale need to be considered. For this purpose experimental and numerical investigations of flow through porous media over a wide range of porosities are necessary. In the present study we sinter glass bead media with various porosities, representing shallow depth crustal sediments. The microstructure, namely effective porosity …
Soil physical quality changes under different management systems after 10 years in the Argentine humid pampa
2015
Abstract. South American countries with the highest surface of land under no-tillage (NT) management are Brazil, Argentina and Chile. In Argentina, 78.5% of the agricultural land is cropped under NT management. Several experiments have confirmed the improvements in soil aggregation and infiltration achieved by NT management in dry-land farming areas associated with increases of bulk density (δb) under NT management. An increase in bulk density implies a reduction of the macro and mesoporosity that is in contradiction with the increased infiltration that occurs at macro and mesopores. We hypothesize that the increase of bulk density in NT management mainly affects the mesopores. We evaluated…
Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells
2015
In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-)…
Enzyme-responsive silica mesoporous supports capped with azopyridinium salts for controlled delivery applications
2012
11 páginas, 7 figuras, 3 tablas y 2 esquemas
Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles
2014
New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate based on a cathepsin B target peptidic sequence were synthesized. Solids were designed to show "zero delivery" and to display cargo release in the presence of cathepsin B enzyme, which selectively hydrolyzed in vitro the capping peptide sequence. Controlled delivery in HeLa, MEFs WT, and MEFs lacking cathepsin B cell lines were also tested. Release of safranin O and doxorubicin in these cells took place when cathepsin B was active or presen…
Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles.
2013
[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.
Protective effect of mesoporous silica particles on encapsulated folates.
2016
Mesoporous silica particles (MSPs) are considered suitable supports to design gated materials for the encapsulation of bioactive molecules. Folates are essential micronutrients which are sensitive to external agents that provoke nutritional deficiencies. Folates encapsulation in MSPs to prevent degradation and to allow their controlled delivery is a promising strategy. Nevertheless, no information exists about the protective effect of MSPs encapsulation to prevent their degradation. In this work, 5-formyltetrahydrofolate (FO) and folic acid (FA) were entrapped in MSPs functionalized with polyamines, which acted as pH-dependent molecular gates. The stability of free and entrapped vitamins af…
Towards chemical communication between gated nanoparticles.
2014
The design of comparatively simple and modularly configurable artificial systems able to communicate through the exchange of chemical messengers is, to the best of our knowledge, an unexplored field. As a proof-of-concept, we present here a family of nanoparticles that have been designed to communicate with one another in a hierarchical manner. The concept involves the use of capped mesoporous silica supports in which the messenger delivered by a first type of gated nanoparticle is used to open a second type of nanoparticle, which delivers another messenger that opens a third group of gated nanoobjects.We believe that the conceptual idea that nanodevices can be designed to communicate with …