Search results for "PREM"
showing 10 items of 1115 documents
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs)
2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations. These mutations in specific genes generate premature termination codons (PTCs) responsible for the translation of truncated proteins. After a brief introduction on nonsense mutations and their pathological effects, the features of various classes of TRIDs will be described discussing differences or similarities in their mechanisms of action. Strategies to correct the PTCs will be presented, particularly focusing on a new class of Ataluren-like oxadiazole derivatives in comparison …
Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology.
2017
Animal and human studies revealed that patterned neuronal activity is an inherent feature of developing nervous systems. This review summarizes our current knowledge about the mechanisms generating early electrical activity patterns and their impact on structural and functional development of the cerebral cortex. All neocortical areas display distinct spontaneous and sensory-driven neuronal activity patterns already at early phases of development. At embryonic stages, intermittent spontaneous activity is synchronized within small neuronal networks, becoming more complex with further development. This transition is accompanied by a gradual shift from electrical to chemical synaptic transmiss…
A solution of the minimum-time velocity planning problem based on lattice theory
2018
For a vehicle on an assigned path, we find the minimum-time speed law that satisfies kinematic and dynamic constraints, related to maximum speed and maximum tangential and transversal acceleration. We present a necessary and sufficient condition for the feasibility of the problem and a simple operator, based on the solution of two ordinary differential equations, which computes the optimal solution. Theoretically, we show that the problem feasible set, if not empty, is a lattice, whose supremum element corresponds to the optimal solution.
Effects of maternal singing during kangaroo care on maternal anxiety, wellbeing, and mother-infant relationship after preterm birth: a mixed methods …
2020
Introduction: Preterm birth may disturb the typical development of the mother– infant relationship, when physical separation and emotional distress in the neonatal intensive care unit may increase maternal anxiety and create challenges for early interaction. This cluster-randomized controlled trial examined the effects of maternal singing during kangaroo care on mothers’ anxiety, wellbeing, and the early mother– infant relationship after preterm birth. Method: In the singing intervention group, a certified music therapist guided the mothers (n = 24) to sing or hum during daily kangaroo care during 33–40 gestational weeks (GW). In the control group, the mothers (n = 12) conducted daily kanga…
Franco’s dictatorship in recent school textbooks: A critical review
2018
Este artículo analiza de forma panorámica el tratamiento de la dictadura franquista en los manuales escolares españoles de educación primaria, secundaria y bachillerato de los últimos veinte años. Se parte de la siguiente premisa: el tratamiento educativo de un pasado conflictivo y “candente” como el del franquismo debe preocupar de forma especial a la comunidad de investigadores y profesores de Historia, en tanto en cuanto tiene profundas repercusiones potenciales en la construcción de las identidades sociopolíticas de las nuevas generaciones. En este sentido, el artículo, aunque no niega los avances producidos, focaliza su atención en las carencias metodológicas, epistemológicas e interpr…
The impact of an urban toll ring on housing prices
2020
Abstract Building on standard urban economics theory we set up a stylized model within which we demonstrate that the imposition of a toll ring leads to higher housing prices within the ring, and lower outside the ring. We examine this prediction empirically by using transaction data for 15,306 dwellings in the Norwegian town of Kristiansand, where since 1992 there has been a toll ring. We find that the toll ring implies 6.9 per cent higher housing prices within the toll ring than outside it. The relationship between toll fees and housing prices seems to be stable over time. The impact of the toll ring on the prices of detached houses, apartments, row houses and twin houses is strikingly dif…
Gütekriterien qualitativer Sozialforschung. Ein Diskussionsanstoß
2018
Zusammenfassung Der Beitrag expliziert Gütekriterien der qualitativen Sozialforschung. Er geht von der Prämisse aus, dass Qualitätsmerkmale in diesem Segment empirischer Sozialforschung nur unter konsequentem Rekurs auf die spezifischen Funktionsbedingungen interpretativer und rekonstruktiver Verfahren zu bestimmen sind. Fünf Kriterien werden vorgeschlagen: Gegenstandsangemessen ist eine Weise der Herstellung des Forschungsgegenstandes, die das empirische Feld ernst nimmt und Methoden, Fragestellungen und Datentypen einer fortlaufenden Justierungsanforderung unterwirft. Empirische Sättigung reflektiert die Güte der Verankerung von Interpretationen im Datenmaterial. Theoretische Durchdringun…
Cuestiones varias en torno a la determinación de la filiación por doble paternidad
2018
The article 7.3 of the law 14/2006, of May 26 on technologies of human assisted reproduction establishes the possibility of determining legally the double maternity of married women and not separated legally or of fact, when the not biological mother consents that filiation decides to his favor the respect of the born son of his spouse. In the suppositions not regulated in the mentioned rule the Supreme Court in relation with equal women?s homosexuality in judgment of December 5, 2013 and January 15, 2014 applies the civil code and allows to determine judicially the maternity by means of the exercise of an action of claim for possession of status foreseen in the article 131. In the present …
Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex
2017
Rodent rhythmic whisking behavior matures during a critical period around 2 weeks after birth. The functional adaptations of neocortical circuitry during this developmental period remain poorly understood. Here, we characterized stimulus-evoked neuronal activity across all layers of mouse barrel cortex before, during, and after the onset of whisking behavior. Employing multi-electrode recordings and 2-photon calcium imaging in anesthetized mice, we tested responses to rostro-caudal whisker deflections, axial "tapping" stimuli, and their combination from postnatal day 10 (P10) to P28. Within this period, whisker-evoked activity of neurons displayed a general decrease in layer 2/3 (L2/3) and …
El delito de impago de pensiones (art. 227 cp) tras la última jurisprudencia del tribunal supremo español (ssts núms. 346/2020 de 25 de junio; 348/20…
2021
Estudio del art. 207 CP en clave jurisprudencial