Search results for "Particle"
showing 10 items of 15225 documents
Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(
2019
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparti…
Charged jet cross sections and properties in proton-proton collisions at $\sqrt{s}=7$ TeV
2015
The differential charged jet cross sections, jet fragmentation distributions, and jet shapes are measured in minimum bias proton-proton collisions at centre-of-mass energy $\sqrt{s}=7$ TeV using the ALICE detector at the LHC. Jets are reconstructed from charged particle momenta in the mid-rapidity region using the sequential recombination $k_{\rm T}$ and anti-$k_{\rm T}$ as well as the SISCone jet finding algorithms with several resolution parameters in the range $R=0.2$ to $0.6$. Differential jet production cross sections measured with the three jet finders are in agreement in the transverse momentum ($p_{\rm T}$) interval $20<p_{\rm T}^{\rm jet,ch}<100$ GeV/$c$. They are also consistent w…
Predicted gamma-ray image of SN 1006 due to inverse Compton emission
2009
We propose a method to synthesize the inverse Compton (IC) gamma-ray image of a supernova remnant starting from the radio (or hard X-ray) map and using results of the spatially resolved X-ray spectral analysis. The method is successfully applied to SN 1006. We found that synthesized IC gamma-ray images of SN 1006 show morphology in nice agreement with that reported by the H.E.S.S. collaboration. The good correlation found between the observed very-high energy gamma-ray and X-ray/radio appearance can be considered as an evidence that the gamma-ray emission of SN 1006 observed by H.E.S.S. is leptonic in origin, though the hadronic origin may not be excluded.
Investigating the Structure of Vela X
2018
Vela X is the prototypical example of a pulsar wind nebula whose morphology and detailed structure have been affected by the interaction with the reverse shock of its host supernova remnant. The resulting complex of filamentary structure and mixed-in ejecta embedded in a nebula that is offset from the pulsar provides the best example we have of this middle-age state that characterizes a significant fraction of composite SNRs, and perhaps all of the large-diameter PWNe seen as TeV sources. Here we report on an XMM-Newton Large Project study of Vela X, supplemented by additional Chandra observations. Through broad spectral modeling as well as detailed spectral investigations of discrete emiss…
Deep-learning based reconstruction of the shower maximum X max using the water-Cherenkov detectors of the Pierre Auger Observatory
2021
The atmospheric depth of the air shower maximum $X_{\mathrm{max}}$ is an observable commonly used for the determination of the nuclear mass composition of ultra-high energy cosmic rays. Direct measurements of $X_{\mathrm{max}}$ are performed using observations of the longitudinal shower development with fluorescence telescopes. At the same time, several methods have been proposed for an indirect estimation of $X_{\mathrm{max}}$ from the characteristics of the shower particles registered with surface detector arrays. In this paper, we present a deep neural network (DNN) for the estimation of $X_{\mathrm{max}}$. The reconstruction relies on the signals induced by shower particles in the groun…
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Cationic solid lipid nanoparticles complexed with genetic material for liver tumor treatment
2015
Concept Gene therapy is a growing field of medicine with great potential for the treatment of several diseases and it is based on the delivery of nucleic acids (DNA, RNA, etc.,) to specific cells. To achieve their therapeutic effects, the nucleic acids need to cross several biological barriers and be protected from the degradation by nucleases, present in biological fluids and intracellular compartments, to successfully gain access to their intracellular targets. To overcome these hurdles, it is necessary to deliver the genetic material with biocompatible carriers able to facilitate its translocation across the cell membranes and protect it from being degraded while circulating in the blood…
ESTIMATING SOIL PARTICLE-SIZE DISTRIBUTION FOR SICILIAN SOILS
2009
The soil particle-size distribution (PSD) is commonly used for soil classification and for estimating soil behavior. An accurate mathematical representation of the PSD is required to estimate soil hydraulic properties and to compare texture measurements from different classification systems. The objective of this study was to evaluate the ability of the Haverkamp and Parlange (HP) and Fredlund et al. (F) PSD models to fit 243 measured PSDs from a wide range of 38 005_Bagarello(547)_33 18-11-2009 11:55 Pagina 38 soil textures in Sicily and to test the effect of the number of measured particle diameters on the fitting of the theoretical PSD. For each soil textural class, the best fitting perf…
Structural properties of core and surface of silica nanoparticles investigated by Raman spectroscopy
2013
We studied the experimental Raman spectra of various commercial silica nanoparticles of average diameter from 7 to 40 nm and specific surface from 50 to 380 m^2/g. We found that the peculiarities of the particles Raman spectra systematically depend on their specific surface. In detail, the peak position of the R band at about 440 cm ^-1 shifts towards high wavenumbers following an almost linear dependence on the specific surface. Similarly, the amplitudes of the D1 and D2 bands, at about 495 and 605 cm ^-1, respectively, increase linearly with the same quantity. Our results are interpreted in the frame of the shell model for the nanoparticles clarifying that the network of the core of the n…
Thioflavin-T doped silica nanoparticles by basic-catalyzed sol-gel synthesis
2014
We developed a basic-catalyzed sol-gel procedure that allows to synthesize silica nanoparticles functionalized with Thioflavin-T (ThT). During the synthesis, the formation of the doped silica nanoparticles was monitored by absorbance spectra indicating that the catalyst does not cause the total hydroxylation of the dye. Fluorescence measurements carried out on the ThT doped silica nanoparticles proved the attachment of ThT on silica and Raman spectroscopy provided information about the dye structure.