Search results for "Phosphinate"
showing 10 items of 21 documents
Phosphinotripeptidic Inhibitors of Leucylaminopeptidases
2021
Phosphinate pseudopeptide are analogs of peptides containing phosphinate moiety in a place of the amide bond. Due to this, the organophosphorus fragment resembles the tetrahedral transition state of the amide bond hydrolysis. Additionally, it is also capable of coordinating metal ions, for example, zinc or magnesium ions. These two properties of phosphinate pseudopeptides make them an ideal candidate for metal-related protease inhibitors. This research investigates the influence of additional residue in the P2 position on the inhibitory properties of phosphinopeptides. The synthetic strategy is proposed, based on retrosynthetic analysis. The N-C-P bond formation in the desired compounds is …
Networks based on hydrogen-bonds containing phosphorus anions and tris(3,5-dimethylpyrazolyl)borate nickel(II) moieties
2012
Abstract Five structural kinds of nickel hydrogen-bonded networks containing hydrotris(3,5-dimethylpyrazolyl)borate ligands (Tp∗) have been elucidated by X-ray diffraction, [Tp∗Ni(OH2)3][(p-NO2C6H4O)2PO2] (4), [Tp∗Ni(OH2)3][Me2PO2]·Me2P(O)OH (5), [Tp∗Ni(OH2)3][(nBuO)2PO2]·0.5H2O (6), [(Hpz)Tp∗Ni(OH2)2][(Ph)PO2OH] (7) and [Tp∗Ni(OH2)2(Me2PO2)] (8). The most relevant supramolecular feature of complexes 4–8 is all of them form coordination networks based on hydrogen bonds between water molecules and phosphate, phosphonate or phosphinate anions. These hydrogen bonds are formed within the monomer units in addition to connect monomers along the chains. Their behaviors in solution were investigate…
m-Carboranylphosphinate as Versatile Building Blocks To Design all Inorganic Coordination Polymers
2017
The first examples of coordination polymers of manganese(II) and a nickel(II) complex with a purely inorganic carboranylphosphinate ligand are reported, together with its exhaustive characterization. X-ray analysis revealed 1D polymeric chains with carboranylphosphinate ligands bridging two manganese(II) centers. The reactivity of polymer 1 with water and Lewis bases has also been studied Thanks to MINECO (CTQ2015-66143-P, CTQ2010-16237 and SEV-2015-0496), Generalitat de Catalunya (2014/SGR/149), and COST CM1302. E.O. who is enrolled in the PhD program of the UAB thanks for FPU grant
A synthetic method for diversification of the P1′ substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1′ bindin…
2007
Abstract A novel, general, and versatile method of diversification of the P1′ position in phosphinic pseudodipeptides, presumable inhibitors of proteolytic enzymes, was elaborated. The procedure was based on parallel derivatization of the amino group in the suitably protected phosphinate building blocks with appropriate alkyl and aryl halides. This synthetic strategy represents an original approach to phosphinic dipeptide chemistry. Its usefulness was confirmed by obtaining a series of P1′ modified phosphinic dipeptides, inhibitors of cytosolic leucine aminopeptidase, through computer-aided design basing on the structure of homophenylalanyl-phenylalanine analogue (hPheP[CH 2 ]Phe) bound in …
Solvent extraction studies of uranium(VI) from phosphoric acid: Role of synergistic reagents in mixture with bis(2-ethylhexyl) phosphoric acid
2014
Abstract The extraction of uranium(VI) from 5.3 mol·L − 1 H 3 PO 4 (a typical concentration of wet phosphoric acid) with a series of neutral organosphosphorus synergistic reagents (0.125–0.250 mol·L − 1 ) used in mixture with 0.5 mol·L − 1 bis(2-ethylhexyl) phosphoric acid (D2EHPA) in Isane IP 185 (a 100% isoparaffinic aliphatic diluent) has been investigated. The series of synergistic reagents includes tri- n -butyl phosphate (TBP), di- n -butyl n -butyl phosphonate (DBBP), n -butyl di- n -butyl phosphinate (BDBP), tri- n -butyl phosphine oxide (TBPO), tri- n -hexyl phosphine oxide (THPO), tri- n -octyl phosphine oxide (TOPO), tri- n -decyl phosphine oxide (TDPO), di- n -hexyl n -decyl pho…
CCDC 706868: Experimental Crystal Structure Determination
2012
Related Article: L.Lopez-Banet, M.D.Santana, G.Garcia, J.Perez, L.Garcia, L.Lezama, M.Liu|2012|Polyhedron|31|575|doi:10.1016/j.poly.2011.10.014
CCDC 1534780: Experimental Crystal Structure Determination
2017
Related Article: Elena Oleshkevich, Clara Viñas, Isabel Romero, Duane Choquesillo-Lazarte, Matti Haukka, Francesc Teixidor|2017|Inorg.Chem.|56|5502|doi:10.1021/acs.inorgchem.7b00610
CCDC 104892: Experimental Crystal Structure Determination
1999
Related Article: J.Ebels, R.Pietschnig, M.Nieger, E.Niecke, S.Kotila|1997|Heteroat.Chem.|8|521|doi:10.1002/(SICI)1098-1071(1997)8:63.0.CO;2-T
CCDC 1434442: Experimental Crystal Structure Determination
2015
Related Article: Elena Oleshkevich, Francesc Teixidor, Duane Choquesillo-Lazarte, Reijo Sillanpää, Clara Viñas|2016|Chem.-Eur.J.|22|3665|doi:10.1002/chem.201504408
N-Benzyl Residues as the P1′ Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases
2020
Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH2-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH). Phosphonamidate pseudopeptides are broadly recognized as competitive mechanism-based inhibitors of metalloenzymes, mainly hydrolases. Their practical use is, however, limited by hydrolytic instability, which is particularly restricting for dipeptide analogs. Extension of phosphonamidates by addition of the methylene group produces a P-C-N system fully resistant in water conditions. In the current work, we present a versatile synthetic approach to such modified dipeptides, based…