Search results for "Porte"
showing 10 items of 1894 documents
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.
2008
SLC5A8 is a member of the sodium/glucose cotransporter family. It has been proposed that SLC5A8 might act as an apical iodide transporter in the thyroid follicular cells or as a transporter of short chain monocarboxylates. We have directly addressed the functional role of SLC5A8 in vivo by generation of SLC5A8 mutant mice. We found that SLC5A8 is responsible for the re-absorption of lactate at the apical membrane of the kidney proximal tubules and of serous salivary gland ducts. In addition, SLC5A8 mediated the uptake of lactate into colonocytes under physiological conditions. We did not find any evidence of SLC5A8 being essential for the apical iodide transport in the thyroid gland, even i…
Endocytosis in skeletal muscle fibers.
1999
Defining the organization of endocytic pathway in multinucleated skeletal myofibers is crucial to understand the routing of membrane proteins, such as receptors and glucose transporters, through this system. Here we analyzed the organization of the endocytic trafficking pathways in isolated rat myofibers. We found that sarcolemmal-coated pits and transferrin receptors were concentrated in the I band areas. Fluid phase markers were taken up into vesicles in the same areas along the whole length of the fibers and were then delivered into structures around and between the nuclei. These markers also accumulated beneath the neuromuscular and myotendinous junctions. The recycling compartment, lab…
Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1
2003
Objectives: Serum is among the agents known to induce hypertrophy of cardiac myocytes, which occurs concomitant with an increase in AP-1-mediated transcription. We have examined if this effect correlates with changes in the relative abundance of particular AP-1 heterodimers, as their exact composition under these conditions is unknown. Furthermore, we obtained insight on the specific role of c-Fos from studying the induction of the glucose transporter GLUT1 by serum in fibroblasts. Methods: We characterised the AP-1 heterodimers expressed in neonatal cardiac myocytes by supershift electrophoretic mobility shift assay (EMSA) analysis. Quantitative changes in transcription were measured using…
La motivation des étudiants à l’entrée à l’université : quels effets directs ou indirects sur la réussite ?
2015
L’enjeu de cet article réside dans la mesure du rôle des capacités motivationnelles des étudiants sur la réussite universitaire, en adoptant une démarche quantitative et intégrative. À cette fin, les données récoltées sur des étudiants en première année de licence de trois filières permettent de contrôler un ensemble de facteurs relatifs aux caractéristiques socio-démographiques et scolaires des étudiants. Mesurée dans le cadre de la théorie de l’autodétermination, il ressort des analyses que la motivation intrinsèque exerce une influence positive tandis que l’amotivation se traduit par de moins bonnes performances. Par ailleurs, la motivation est un atout pour les bons étudiants, mais ne j…
Situational and dispositional factors as predictors of precompetitive anxiety and self-confidence in college athletes
2015
Apoyados en la teoría de la autodeterminación y la teoría de las metas de logro, el objetivo del presente estudio fue poner a prueba dos modelos que examinan secuencialmente las relaciones entre factores situacionales (clima motivacional creado por el entrenador), factores disposicionales (orientaciones de meta y regulaciones motivacionales), y consecuencias de ansiedad y autoconfianza precompetitivas (considerando sus dimensiones de intensidad y dirección). También se analizó el papel mediador de las orientaciones de meta y de las regulaciones motivacionales, en la relación entre el clima motivacional y la ansiedad y autoconfianza precompetitivas. Se utilizó un diseño transversal de recogi…
Parenté et fraternité monastique dans les miracles posthumes de saint Honorat (Vita sancti Honorati, BHL 3976, fin XIIIe siècle)
2008
Kinship and monastic fraternity in the saint Honoratus miracles at the end of the 13th century (Vita sancti Honorati - BHL 3976) - The legendary Life of saint Honoratus, founding abbot of Lerins and archbishop of Arles (BHL 3976), is a long anonymous narrative of the end of the 13th century. The chapters 30-48 gather together 37 posthumous miracles of the saint. These narratives, close to the contemporary exempla, are rich in moral teachings and display the social relationships representations from the monastic fraternity ideal pattern viewpoint. They point out the insertion of the conjugal unit in a large fabric of horizontal relationships converging to Lerins, and the sexual behavioral co…
Ultracytochemical localization of Ca2(+)-ATPase activity in the middle ear mucosa of the guinea pig.
1989
Ca2(+)-ATPase activity was studied ultra-cytochemically in the middle ear mucosa of the guinea pig. On electron microscopic examination, the most intense reaction was found on the microvilli. Reaction products were also observed on the cilia and around and between the secretory granules on the apical side of the cells in their secretory phase. The basolateral membranes contained few reaction products, while very little or no activity was found on the basal membrane.
Multimedia application to support distance learning and other social interactions in real-time
2000
Supporting social interactions, in distance learning situations for example, with modern technology is very difficult. Generally Internet, networked PC, document handling and communication services and applications are not designed from a multiple user perspective but to support a one-person-one-device (or tool) interaction. This approach creates problems for supporting awareness of, and communication with other people while simultaneously working on documents. Such simultaneous activities have been identified as essential by CSCW and CHI studies, where users are reported to move promiscuously between media and devices, and combine applications and media intuitively, while maintaining aware…
Critical approach to 3D virtual realities for group work
2002
Collaborative virtual environments (CVEs) have been studied extensively during the past few years. In this paper, the concept of virtual reality (VR), and its value for group work are critically examined. To ground the discussions, experiences from a virtual reality project, from 3D chats, and from present CVE applications are analysed in the light of human communication. It is argued that the value of virtual reality is often overemphasised and overrated in the group work context, especially when conce rning desktop virtual realities and generic groupwork without an explicitly defined task or purpose. The main problem with VR is its self-centricity and inadequate support for shared real-li…
Communities in Technology-Enhanced Environments for Learning
2009
The contemporary society addresses complex, interrelated, and interactive global situations to be faced by its citizens. Instead of pursuing solitary actions, this post-modern turn requires its actors to develop capacities to resituate their activities in collective unities and to successfully communicate their actions within these multiple local and global communities. Also in education, the concept of community continues to possess a positive image and the optimistic premises of how communication technologies may enable communities to grow have been widely discussed. For example, in higher education, educational practices (e.g. Virtual University) are more often fixed around Web-based col…