Search results for "Procedures"

showing 10 items of 1678 documents

Obstetric and Neonatal Outcome of Pregnancies Fathered by Males on Immunosuppression After Solid Organ Transplantation

2015

Immunosuppressive drugs may influence spermatogenesis, but little is known about outcome of pregnancies fathered by transplanted males. We estimated risk of adverse outcomes in pregnancies (with data after the first trimester) fathered by males that had undergone organ transplantation and were treated with immunosuppression. A population-based study, linking data from the Norwegian transplant registry and the Medical Birth Registry of Norway during 1967-2009 was designed. All Norwegian men undergoing solid organ transplantation were included. Odds ratios for major malformations, preeclampsia, preterm delivery (<37 weeks) and small-for-gestational-age were obtained using logistic regression.…

Graft RejectionMaleimmunosuppressantmedicine.medical_treatmentOrgan transplantationCohort StudiesFathersPre-EclampsiaObstetrics and gynaecologyPregnancyRisk FactorsImmunology and AllergyPharmacology (medical)Registrieseducation.field_of_studyNorwayObstetricsPregnancy OutcomeImmunosuppressionMiddle Agedpracticesurgical procedures operativePremature BirthFemalepregnancyImmunosuppressive AgentsLung TransplantationAdultmedicine.medical_specialtyAdolescentPopulationCongenital AbnormalitiesPreeclampsiaYoung AdultmedicineHumansSpermatogenesiseducationRetrospective Studiesobstetrics and gynecologyTransplantationPregnancybusiness.industryOrgan TransplantationOdds ratiomedicine.diseasehealth services and outcomes researchKidney TransplantationLiver TransplantationSurgeryPregnancy ComplicationsTransplantationclinical researchHeart Transplantationbusiness
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Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Regist…

2019

BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study. METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T.…

Graft RejectionMalemedicine.medical_specialtyTime FactorsDrug Compoundingmedicine.medical_treatmentCalcineurin InhibitorsMedizinMEDLINEchemical and pharmacologic phenomenaLiver Transplant030230 surgeryLiver transplantationRisk AssessmentTacrolimusall contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)03 medical and health sciences0302 clinical medicineRisk FactorsProlonged releaseInternal medicinemedicineHumansAged; Calcineurin Inhibitors; Delayed-Action Preparations; Drug Compounding; Europe; Female; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Male; Middle Aged; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Tacrolimus; Time Factors; Treatment Outcome; Liver TransplantationRegistriesAgedRetrospective StudiesTransplantationbusiness.industryGraft SurvivalImmunosuppressionRetrospective cohort studyMiddle AgedTacrolimusSettore MED/18Liver Transplantation3. Good healthEuropeTreatment Outcomesurgical procedures operativeDelayed-Action PreparationsFemale030211 gastroenterology & hepatologyTransplant patientbusinessRisk assessmentImmunosuppressive AgentsTransplantation
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Donor/recipient algorithm for management of the middle hepatic vein in right graft live donor liver transplantation

2010

Abstract Background The aim of this study was to delineate an algorithm for donor and recipient criteria and middle hepatic vein (MHV) management in right-graft live-donor liver transplantation (LDLT) on the basis of computerized 3-dimensional computed tomographic image analysis. Methods Data on 94 consecutive right-graft LDLTs were prospectively collected. Graft and remnant data for the first 23 cases were retrospectively evaluated by means of 3-dimensional computed tomographic reconstructions, and on the basis of that preliminary series, a graft selection algorithm using 3 parameters—hepatic vein dominance classification, graft and remnant graft volume/body weight ratios, and congestion v…

Graft RejectionMalemedicine.medical_specialtyTissue and Organ ProcurementLive donormedicine.medical_treatmentHepatic VeinsLiver transplantationliverBody weightRisk AssessmentPreoperative careComputed tomographicCohort StudiesImaging Three-DimensionalPostoperative ComplicationsPreoperative CareLiving DonorsmedicineGraft selectionHepatectomyHumansProspective StudiesAnalysis of VarianceSmall for size syndromebusiness.industryPatient SelectionGraft SurvivalGeneral MedicineLiver TransplantationSurgeryTreatment Outcomesurgical procedures operativeMathematikFemaleSurgeryHepatectomyTomography X-Ray ComputedbusinessAlgorithmAlgorithmsFollow-Up StudiesLiver CirculationThe American Journal of Surgery
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The effect of ischemia/reperfusion on the kidney graft.

2014

Ischemia/reperfusion injury is an unavoidable companion after kidney transplantation and influences short-term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that eventually result in a distinct inflammatory reaction of the kidney graft.Underlying factors include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necr…

Graft RejectionTransplantationmedicine.medical_specialtyKidneyGraft dysfunctionGraft rejectionbusiness.industryT-LymphocytesIschemiamedicine.diseaseKidney TransplantationDelayed Graft FunctionImmunity InnateSurgerysurgical procedures operativemedicine.anatomical_structureImmunityReperfusion InjurymedicineImmunology and AllergyAnimalsHumansbusinessReperfusion injuryKidney transplantationCurrent opinion in organ transplantation
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Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients

2013

The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant. However, despite the long use of tacrolimus in clinical practice, the best way to use this agent is still a matter of intense debate. The start of the genomic era has generated new research areas, such as pharmacogenetics, which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body. This variability seems to be correlated with the presence of genetic polymorphisms. Genotyping is an attractive option especially for the initiation of the dosing of tacrolim…

Graft Rejectionmedicine.medical_specialtyCYP3A5ATP Binding Cassette Transporter Subfamily BCYP3A4Genotypemedicine.medical_treatmentPharmacologyLiver transplantationBioinformaticsOrgan transplantationTacrolimusCalcineurin inhibitorMedicineCytochrome P-450 CYP3AHumansDrug Dosage CalculationsDosingATP Binding Cassette Transporter Subfamily B Member 1Topic HighlightKidney transplantLiver transplantKidney transplantationBiotransformationPolymorphism Geneticbusiness.industryPharmacogeneticGraft SurvivalGastroenterologyABCB1General Medicinemedicine.diseaseKidney TransplantationTacrolimusLiver TransplantationSingle nucleotide polymorphismTransplantationsurgical procedures operativePhenotypeTreatment OutcomePharmacogeneticsTacrolimuSettore BIO/14 - FarmacologiaPersonalized medicinebusinessPharmacogeneticsImmunosuppressive Agents
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Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus

2013

Objective To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. Design Experimental study. Setting University laboratory. Animal(s) Female rats. Intervention(s) Uteri from brown Norway rats were transplanted to Lewis rats, receiving either tacrolimus or no treatment. Sham groups underwent either hemihysterectomy or tacrolimus treatment. Main Outcome Measure(s) Gross morphology, histology, density of T-lymphocytes by immunohistochemistry, and mRNA levels of interleukin (IL)-1α, leukemia inhibitory factor (LIF), galectin-1, CD200, IL-15, interferon-inducible protein-10 (IP-10), a…

Graft Rejectionmedicine.medical_specialtyNecrosisGalectin 1UterusHysterectomyTacrolimusAndrologyNecrosisInterleukin-1alphaRats Inbred BNInternal medicineUterus transplantationmedicineAnimalsTransplantation HomologousInflammationbusiness.industryUterusObstetrics and GynecologyInterleukinHistologyOrgan TransplantationTacrolimusRatsChemokine CXCL10Transplantationsurgical procedures operativeEndocrinologymedicine.anatomical_structureReproductive MedicineRats Inbred LewFemalemedicine.symptombusinessLeukemia inhibitory factorBiomarkersImmunosuppressive AgentsFertility and Sterility
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Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies

2014

The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of CYP3A5 6986A>G, but the evidence is not clear. We conducted a meta-analysis of studies evaluating the effect of CYP3A5 polymorphism on kidney transplant recipients with tacrolimus plasma concentration divided by daily dose per body weight (C/D) and clinical outcomes. We searched in MEDLINE and EMBASE. We found evidence suggesting a significantly lower C/D among CYP3A5*1 allele carriers compared with carriers of the CYP3A5*3/*3 genotype at weeks 1 and 2, and months 1, 3, 6 and 12. We demonstrated that the expre…

Graft Rejectionmedicine.medical_specialtyPharmacologyGastroenterologyKidney transplantTacrolimusPharmacokineticsInternal medicineGenotypeGeneticsmedicineCytochrome P-450 CYP3AHumansAlleleCYP3A5Pharmacologybusiness.industryKidney TransplantationTransplant RecipientsTacrolimusObservational Studies as Topicsurgical procedures operativeMeta-analysisMolecular MedicineObservational studybusinessImmunosuppressive Agents
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Transanal coloanal anastomosis for Hirschsprung's disease: comparison between endorectal and perirectal pull-through procedures.

2006

Le but de cette etude est de comparer les resultats de 2 techniques chirurgicales d'abaissement transanal par voie perineale pour maladie de Hirschsprung de forme recto-sigmoidienne. Materiel et Methode: Vingt-et-un patients porteurs de maladie de Hirschsprung de forme recto-sigmoidienne ont ete consecutivement operes entre novembre 1999 et avril 2003 dans les services de Chirurgie Pediatrique de Dijon et Strasbourg. Les 21 enfants ont ete operes par voie perineale transanale: Douze d'entre eux ont eu une dissection peri-rectale (TPR) et 9 une endorectale type Soave (TER). Les 2 groupes de patients ont ete compares pour la longueur du segment aganglionnaire, l'âge et le poids au moment de l…

GynecologyMalemedicine.medical_specialtybusiness.industryColonAnastomosis SurgicalInfant NewbornAnal CanalInfantLength of Staymedicine.diseaseMulticenter studyColon surgeryPediatrics Perinatology and Child HealthMedicineHumansSurgeryFemaleLaparoscopyHirschsprung DiseasebusinessColoanal anastomosisHirschsprung's diseaseDigestive System Surgical ProceduresEuropean journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
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The Thin bilateral and bipedicled DIEAP flap for axillary reconstruction in hidradenitis suppurativa

2019

Reconstruction after resection of advanced stage hidradenitis suppurativa is currently performed with pedicled perforator flaps, that allow functional reconstruction and preservation of shoulder function. Skin availability is limited by the possibility of closing the donor site primarily. Bilateral cases need to be treated in two stages, since the operation is carried out in the lateral decubitus. In this manuscript the application of bilateral and bipedicled DIEAP flaps to bilateral and extensive cases is presented.Between October 2008 and October 2018, 39 patients were treated for axillary hidradenitis suppurativa. Of these, 11 patients had bilateral reconstruction with bilateral DIEAP fl…

GynecologyMicrosurgery030222 orthopedicsmedicine.medical_specialtybusiness.industrySettore MED/19 - Chirurgia PlasticaPlastic Surgery Procedures030230 surgerymedicine.diseaseDIEAP flap - thin perforator flap - hidradenitis suppurativa - axillary reconstructionSurgical FlapsHidradenitis Suppurativa03 medical and health sciences0302 clinical medicineLipectomyAxillaDIEAP flap thin perforator flap hidradenitis suppurativa axillary reconstructionmedicineHumansOrthopedics and Sports MedicineSurgeryHidradenitis suppurativaSurgical treatmentbusinessPerforator Flap
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Improvements of General Multiple Test Procedures for Redundant Systems of Hypotheses

1988

In dieser Arbeit wird untersucht, welche Verscharfungen allgemeiner multipler Testprozeduren moglich sind, wenn die Kenntnis von „Redundanzen“ (logischen Abhangigkeiten) im Hypothesensystem ganz oder teilweise ausgenutzt wird. Fur den Fall gleicher Gewichtung der Elementartests werden mehrere verbesserte „statische“ Prozeduren angegeben, unter denen sich auch die „MSRB-Prozedur“ von Shaffer (1986) befindet. Last man auch ungleiche Gewichtung zu, so erhalt man vier verschiedene „dynamische“ Verbesserungen der Prozedur von Holm (1979), die in aufsteigender Reihenfolge immer trennscharfer, aber auch immer rechenaufwendiger werden. Es werden praktikable Algorithmen vorgestellt, die in einem ent…

Gynecologymedicine.medical_specialtyTest proceduresPhilosophyStatisticsmedicine
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