Search results for "R15"
showing 10 items of 35 documents
Expression of miR159 Is Altered in Tomato Plants Undergoing Drought Stress.
2019
In a scenario of global climate change, water scarcity is a major threat for agriculture, severely limiting crop yields. Therefore, alternatives are urgently needed for improving plant adaptation to drought stress. Among them, gene expression reprogramming by microRNAs (miRNAs) might offer a biotechnologically sound strategy. Drought-responsive miRNAs have been reported in many plant species, and some of them are known to participate in complex regulatory networks via their regulation of transcription factors involved in water stress signaling. We explored the role of miR159 in the response of Solanum lycopersicum Mill. plants to drought stress by analyzing the expression of sly-miR159 and …
Novel DNA Methylation Sites Influence GPR15 Expression in Relation to Smoking
2018
Smoking is a major risk factor for cardiovascular diseases and has been implicated in the regulation of the G protein-coupled receptor 15 (GPR15) by affecting CpG methylation. The G protein-coupled receptor 15 is involved in angiogenesis and inflammation. An effect on GPR15 gene regulation has been shown for the CpG site CpG3.98251294. We aimed to analyze the effect of smoking on GPR15 expression and methylation sites spanning the GPR15 locus. DNA methylation of nine GPR15 CpG sites was measured in leukocytes from 1291 population-based individuals using the EpiTYPER. Monocytic GPR15 expression was measured by qPCR at baseline and five-years follow up. GPR15 gene expression was upregulated i…
The Covid-19 containment effects of public health measures:A spatial difference-in-differences approach
2021
Abstract The paper studies the containment effects of public health measures to curb the spread of Covid‐19 during the first wave of the pandemic in spring 2020 in Germany. To identify the effects of six compound sets of public health measures, we employ a spatial difference‐in‐differences approach. We find that contact restrictions, mandatory wearing of face masks and closure of schools substantially contributed to flattening the infection curve. The significance of the impact of restaurant closure does not prove to be robust. No incremental effect is evidenced for closure of establishments and the shutdown of nonessential retail stores.
The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?
2002
International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …
Deinococcus radiodurans' SRA-HNH domain containing protein Shp (Dr1533) is involved in faithful genome inheritance maintenance following DNA damage
2018
WOS:000452343100012; International audience; Background: Deinococcus radiodurans R1 (DR) survives conditions of extreme desiccation, irradiation and exposure to genotoxic chemicals, due to efficient DNA breaks repair, also through Mn2+ protection of DNA repair enzymes. Methods: Possible annotated domains of the DR1533 locus protein (Shp) were searched by bioinformatic analysis. The gene was cloned and expressed as fusion protein. Band-shift assays of Shp or the SRA and HNH domains were performed on oligonucleotides, genomic DNA from E. coif and DR. slip knock-out mutant was generated by homologous recombination with a kanamycin resistance cassette. Results: DR1533 contains an N-terminal SRA…
Automata and differentiable words
2011
We exhibit the construction of a deterministic automaton that, given k > 0, recognizes the (regular) language of k-differentiable words. Our approach follows a scheme of Crochemore et al. based on minimal forbidden words. We extend this construction to the case of C\infinity-words, i.e., words differentiable arbitrary many times. We thus obtain an infinite automaton for representing the set of C\infinity-words. We derive a classification of C\infinity-words induced by the structure of the automaton. Then, we introduce a new framework for dealing with \infinity-words, based on a three letter alphabet. This allows us to define a compacted version of the automaton, that we use to prove that ev…
On the Number of Closed Factors in a Word
2015
A closed word (a.k.a. periodic-like word or complete first return) is a word whose longest border does not have internal occurrences, or, equivalently, whose longest repeated prefix is not right special. We investigate the structure of closed factors of words. We show that a word of length $n$ contains at least $n+1$ distinct closed factors, and characterize those words having exactly $n+1$ closed factors. Furthermore, we show that a word of length $n$ can contain $\Theta(n^{2})$ many distinct closed factors.
Cyclic Complexity of Words
2014
We introduce and study a complexity function on words $c_x(n),$ called \emph{cyclic complexity}, which counts the number of conjugacy classes of factors of length $n$ of an infinite word $x.$ We extend the well-known Morse-Hedlund theorem to the setting of cyclic complexity by showing that a word is ultimately periodic if and only if it has bounded cyclic complexity. Unlike most complexity functions, cyclic complexity distinguishes between Sturmian words of different slopes. We prove that if $x$ is a Sturmian word and $y$ is a word having the same cyclic complexity of $x,$ then up to renaming letters, $x$ and $y$ have the same set of factors. In particular, $y$ is also Sturmian of slope equ…
Anti-powers in infinite words
2018
In combinatorics of words, a concatenation of $k$ consecutive equal blocks is called a power of order $k$. In this paper we take a different point of view and define an anti-power of order $k$ as a concatenation of $k$ consecutive pairwise distinct blocks of the same length. As a main result, we show that every infinite word contains powers of any order or anti-powers of any order. That is, the existence of powers or anti-powers is an unavoidable regularity. Indeed, we prove a stronger result, which relates the density of anti-powers to the existence of a factor that occurs with arbitrary exponent. As a consequence, we show that in every aperiodic uniformly recurrent word, anti-powers of ev…
Factorizations of the Fibonacci Infinite Word
2015
The aim of this note is to survey the factorizations of the Fibonacci infinite word that make use of the Fibonacci words and other related words, and to show that all these factorizations can be easily derived in sequence starting from elementary properties of the Fibonacci numbers.