Search results for "RATES"
showing 10 items of 1636 documents
Transcriptional Activity and Nuclear Localization of Cabut, the Drosophila Ortholog of Vertebrate TGF-β-Inducible Early-Response Gene (TIEG) Proteins
2011
Background Cabut (Cbt) is a C2H2-class zinc finger transcription factor involved in embryonic dorsal closure, epithelial regeneration and other developmental processes in Drosophila melanogaster. Cbt orthologs have been identified in other Drosophila species and insects as well as in vertebrates. Indeed, Cbt is the Drosophila ortholog of the group of vertebrate proteins encoded by the TGF-s-inducible early-response genes (TIEGs), which belong to Sp1-like/Kruppel-like family of transcription factors. Several functional domains involved in transcriptional control and subcellular localization have been identified in the vertebrate TIEGs. However, little is known of whether these domains and fu…
ADR1 and SNF1 Mediate Different Mechanisms in Transcriptional Regulation of Yeast POT1 Gene
1994
We studied the consequences of adr1 and snf1 mutations on POT1 gene expression in different growth conditions. The results obtained reveal that ADR1 and SNF1 genes affect POT1 transcription in different ways: ADR1 has a minor role in derepression in low concentration of glucose but is essential for activation in stationary phase whereas SNF1 is essential for derepression and activation, although it does not seem to be directly involved in the molecular mechanism of activation in stationary phase.
Collapse or Continuity? The case of the EB-MB transition at Tell Shiyukh Tahtani
2007
La fin du Troisieme Millenaire est, dans l'histoire du Proche-Orient ancien, une periode sujette a contro¬verses car, selon les regions, elle connalt soil une disintegration et un effondrement culturels, soil une conti¬nuite et un developpement urbains. Le tableau general de la situation reste confus, particulierement en. Syrie, ou it a fait /'objet d'un grand nombre de theories et de modeles d'interpretation. La periode de "transition" entre le Bronze Ancien et le Bronze Moyen est ici consideree du point de vue d'un petit site rural de la vallee de l'Euphrate en Syrie du Nord, Tell Shiyukh Tahtani. Les fouilles recentes realisees par l'Universite de Palerme y ant mis au jour une longue seq…
Tributyltin(Iv) butyrate: A novel epigenetic modifier with er stress-and apoptosis-inducing properties in colon cancer cells
2021
Organotin(IV) compounds are a class of non-platinum metallo-conjugates exhibiting antitumor activity. The effects of different organotin types has been related to several mechanisms, including their ability to modify acetylation protein status and to promote apoptosis. Here, we focus on triorganotin(IV) complexes of butyric acid, a well-known HDAC inhibitor with antitumor properties. The conjugated compounds were synthesized and characterised by FTIR spectroscopy, multi-nuclear (1H, 13C and 119Sn) NMR, and mass spectrometry (ESI-MS). In the triorganotin(IV) complexes, an anionic monodentate butyrate ligand was observed, which coordinated the tin atom on a tetra-coordinated, monomeric enviro…
Autecology, lifestyle and hydrodynamics of early vertebrates
2018
Capítulo 1. Introducción general Los vertebrados constituyen uno de los grupos de animales más exitosos, contando con más de 60000 especies distintas y ocupando la gran mayoría de ecosistemas marinos y continentales. Su origen y evolución han sido temas centrales para biólogos y paleontólogos durante décadas, pero las discusiones en este sentido se han visto obstaculizadas porque los grupos actuales (ciclóstomos, condrictios y osteíctios) constituyen solo una pequeña representación de toda la diversidad que existió en el pasado. Por lo tanto, el registro fósil es crucial para arrojar luz sobre estos aspectos permitiendo desvelar el momento y el tempo de la aparición de los diferentes caract…
Medicina, ciencia, humanidad: el médico hipocrático
2011
Breve revisión de algunas de las características del médico hipocrático. This is a brief review of some of the features of the Hippocratic Doctor.
Association between Intake of Energy and Macronutrients and Memory Impairment Severity in US Older Adults, National Health and Nutrition Examination …
2020
Without a cure, dementia affects about 50 million people worldwide. Understanding the effects of dietary habits, a key lifestyle behavior, on memory impairment is critical to inform early behavioral modification to delay further memory loss and progression to dementia. We examined the associations of total energy intake and energy intake from macronutrients with memory impairment among older US adults using data from the nationally representative National Health and Nutrition Examination Survey study 2011&ndash
Identifying and validating the presence of guanine-quadruplexes (G4) within the blood fluke parasite schistosoma mansoni
2021
Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomiasis by praziquantel has limitations, new strategies for managing disease burden are urgently needed. A better understanding of schistosome biology could identify previously undocumented areas suitable for the development of novel interventions. Here, for the first time, we detail the presence of G-quadruplexes (G4) and putative quadruplex forming sequences (PQS) within the Schistosoma mansoni genome. We find that G4 are present in both intragenic and intergenic regi…
Giustizia ambientale e recupero delle aree verdi: il caso di Palermo
2021
L’urban shrinkage è diventata una questione centrale tanto nel dibattito scientifico quanto nell’agenda politica di diverse città europee. Secondo i dati EUROSTAT (2019), circa il 40% delle città europee con più di 200.000 abitanti stanno perdendo popolazione; una contrazione che si esplicita maggiormente, sotto il profilo spaziale, in una progressiva sottoutilizzazione del patrimonio edificato, così come nel contestuale incremento di aree e terreni in stato di abbandono. In questo quadro controverso di mutazione strutturale della città, così come l’abbiamo conosciuta, le politiche urbane alla prova in Europa tentano di declinare la decrescita quale occasione strategica di investimento sull…
Birokrātismi sabiedriskajā saziņā
2016
Darbs pēta birokrātismus sabiedriskajā saziņā. Darba mērķis ir izpētīt, kā veidojas nozīme Eiropas Savienības (ES) diskursā un atklāt vissarežģītākos aspektus priekš tiem valodas lietotājiem, kam angļu valoda nav dzimtā. Šī darba loks ir sašaurināts līdz vienam programmas Horizon 2015 dokumentam, un visi piemēri šajā darbā ir ņemti no iepriekšminētā dokumenta. Pētnieciskā metode ir diskursa analīze. Autore pieradīja ka zināmas birokrātismu pazīmes, kā īpašības vārdi un modalitāte, var rādīt dokumentā neskaidrību . Šī darba rezultāti ir piemēru, paskaidrojumu un rekomendāciju kopsavilkums, kas varētu palīdzēt strādāt ar neskaidras valodas gadījumiem un ES dokumentācijas praktisks pētījums, k…