Search results for "RECIPIENTS"

Sirolimus exposure and the occurrence of cytomegalovirus DNAemia after allogeneic hematopoietic stem cell transplantation

2018

Sirolimus appears to protect against cytomegalovirus (CMV) in organ transplant recipients. The effect of this drug in allogeneic hematopoietic stem cell transplantation recipients remains unexplored. By means of multivariate continuous-time Markov model analyses, we identified 3 independent covariates that significantly impacted the risk of CMV DNAemia: recipient/donor CMV serostatus, tacrolimus exposure, and sirolimus exposure. CMV-seropositive recipients with CMV-seronegative donors had a significantly higher probability of having detectable CMV DNAemia. Increasing the tacrolimus trough concentration from 0 to 16 ng/mL increased the probability of patients having detectable CMV DNAemia by…

CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review

2021

Patients with postransplant lymphoproliferative disease (PTLD) who are refractory to rituximab-based regimens have extremely poor prognosis. Data is lacking in the setting of solid organ transplantation (SOT)-related PTLD treated with chimeric antigen receptor T-cell (CAR-T) therapy. Moreover, limited information is available on the influence of concomitant immunosuppressive drugs on CAR-T function. Here, we describe the clinical outcome in one PTLD patient and propose a strategy for tailoring immunosuppressive treatment and organ monitoring in patients with kidney allografts after CAR-T infusion. This report also reviews the limited published data in the setting of SOT-related PTLD treated…

Ex-vivo generation and in-vivo infusion of Herpesvirus-specific T cells to treat virus-induced pathologies in transplant recipients.

2011

Single center report on complications in steroid-free immunosuppressive therapy of liver transplant recipients

2010

Human genetic polymorphisms and risk of viral infection after solid organ transplantation.

2021

The immune system plays a key role in the host defense against viral pathogens. A signaling cascade is activated upon infection involving a variety of molecules such as pattern-recognition receptors (PRRs), interleukins or antiviral interferons. Long-term immunosuppression after solid organ transplantation (SOT) mainly abrogates adaptive T-cell-mediated responses, thus highlighting the relative contribution of innate immunity. Single-nucleotide polymorphisms (SNPs) within genes coding for PRRs or soluble mediators have been associated with differential susceptibility to viral infections among SOT recipients. A protective effect against cytomegalovirus (CMV) infection or disease has been att…

Kardiovaskulārā riska izvērtējums pacientiem ar nieres transplantātu

2022

Viens no biežākajiem nāves iemesliem pacientiem ar funkcionējošu nieres transplantātu ir kardiovaskulāri (KV) notikumi. Lai savlaicīgi varētu veikt preventīvu ārstēšanu un uzlabot nieres transplantāta recipientu dzīvildzi, ir nozīmīgi izvērtēt svarīgākos KV riska faktorus un to ietekmi uz KV notikumu attīstību. Retrospektīva pētījuma mērķis bija izvērtēt KV notikumu incidenci, riska faktorus un nieres transplantācijas (NT) iznākumus pacientiem ar KV notikumiem. Pētījumā tika iekļauti 184 pacienti. Datu analīzei pacienti tika sadalīti divās grupās: pacienti ar KV notikumiem un pacienti bez KV notikumiem. Glomerulārās filtrācijas ātrums tika aprēķināts pēc CKD-EPI Creatinine, 2021 formulas. R…

Przeszczepy narządowe w okresie epidemii COVID-19

2020

Epidemia COVID-19 zmieniła podejście do kwalifikacji dawców i biorców przeszczepów narządowych. Kwalifikacja następuje po obowiązkowym wykonaniu tomografii komputerowej płuc i testu RT-PCR na obecność wirusa, w wyniku indywidualnej oceny korzyści i ryzyka zakażenia. W bardziej odległym okresie od transplantacji na ciężkość objawów w większym stopniu niż leczenie immunosupresyjne wpływają zaawansowany wiek i współchorobowości. Pierwszym krokiem w redukcji leczenia immunosupresyjnego u biorców przeszczepów narządowych jest odstawienie leku antyproliferacyjnego z pozostawieniem inhibitora kalcyneuryny i steroidów. Terapia immunosupresyjna znamiennie wydłuża czas eliminacji wirusa, ale może ogr…

Rīcības ar cilvēka audiem un orgāniem regulējums Latvijā

2019

Darba tēma ir „Rīcības ar cilvēka audiem un orgāniem regulējums Latvijā”. Šobrīd, kad pasaulē strauji attīstās tāda medicīnas nozare kā cilvēka audu un orgānu transplantācija, pieaug arī cilvēka ķermeņa nelikumīgas izmantošanas gadījumi. Lai arī audu un orgānu nelikumīgas izmantošanas prakse Latvijā ir reti sastopama, arī šiem gadījumiem jāparedz atbilstošs regulējums starptautiskajiem tiesību avotiem. Darba mērķis bija noskaidrot, par kādām nelikumīgām darbībām ar cilvēka audiem un orgāniem ir paredzēta kriminālatbildība Latvijā, kādi ir embriju (fetālo) audu izmantošanas tiesiskie aspekti, un salīdzināt Latvijas tiesisko regulējumu ar starptautisko un ārvalstu regulējumu. Transplantācijas…

Italian association for the study of the liver position statement on SARS-CoV2 vaccination.

2021

The vaccination campaign against Sars-CoV-2 commenced in Italy at the end of December 2020. The first ones to receive the immunization against the virus were the health workers and the residents of nursing homes, following which the vaccine would be available for the entire population, beginning with the most vulnerable individuals. SARS-CoV2 vaccines have been demonstrated to be safe for the general population, although no data for patients with liver diseases or those having undergone liver transplantation are available so far. The present position statement AISF is an attempt to suggest, based on the published data on the impact of Sars-Cov-2 infection in patients with chronic liver dise…

Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations.

2016

Cytomegalovirus (CMV) infection remains a major complication of solid organ transplantation. Because of management of CMV is variable among transplant centers, in 2011 the Spanish Transplantation Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) developed consensus guidelines for the prevention and treatment of CMV infection in solid organ transplant recipients. Since then, new publications have clarified or questioned the aspects covered in the previous document. For that reason, a panel of experts revised the evidence on CMV management, including immunological monitoring, diagnostics, prevention, vaccines, indirect effects, tre…