Search results for "RESISTANCE"
showing 10 items of 3641 documents
A synthetic derivative of antimicrobial peptide holothuroidin 2 from mediterranean sea cucumber (Holothuria tubulosa) in the control of Listeria mono…
2019
Due to the limited number of available antibiotics, antimicrobial peptides (AMPs) are considered antimicrobial candidates to fight difficult-to-treat infections such as those associated with biofilms. Marine environments are precious sources of AMPs, as shown by the recent discovery of antibiofilm properties of Holothuroidin 2 (H2), an AMP produced by the Mediterranean sea cucumber Holothuria tubulosa. In this study, we considered the properties of a new H2 derivative, named H2d, and we tested it against seven strains of the dangerous foodborne pathogen Listeria monocytogenes. This peptide was more active than H2 in inhibiting the growth of planktonic L. monocytogenes and was able to interf…
Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes.
2015
International audience; Diabetes is a chronic metabolic disease with a high prevalence worldwide. Diabetes and insulin resistance are associated with the development of cardiovascular and nervous diseases. The development of these disorders reflects complex pathological processes in which the oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) plays a pivotal role. It is widely accepted that diabetes impairs endothelial nitric oxide synthase (eNOS) activity and increases the production of ROS, thus resulting in diminished NO bioavailability and increased oxidative stress. Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and …
3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma
2020
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 and Panc-1. Compounds 9c and 9l, showed relevant in vitro antiproliferative activity on all three pre-clinical models with half maximal inhibitory concentration (IC50) ranging from 5.11 to 10.8 µ
Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole derivatives: as anticancer and antibiofilm agents, and preclinical invest…
2020
3-(6-Phenylimidazo [2,1-
2019
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 and Panc-1. Compounds 9c and 9l, showed relevant in vitro antiproliferative activity on all three pre-clinical models with half maximal inhibitory concentration (IC50) ranging from 5.11 to 10.8 µM, while the compounds 9e and 9n were active in at least one cell line. In addition, compound 9c significantly inhibited the migration rate of SUIT-2 and Capan-1 cells in the scratch wound-healing assay. In conclusion, our results will support further studies to increa…
Political Action Beyond Resistance: Arendt and "Revolutionary Spirit" in Egypt
2016
The article examines what it calls the "politics-as-resistance" frame in contemporary political theory, originating in the works of Michel Foucault and Judith Butler. This way of organizing political experience is contrasted with Hannah Arendt's political thought, particularly her writings on revolutionary action. Arendt's often overlooked – and partly unpublished – passages on virtù and fortuna are further suggested as important additions to her thinking on action. I argue that Arendt's "world-centric" approach can illuminate certain aspects of political experience that remain dimmed in the more subject-oriented politics-as-resistance frame. Particular focus is paid to the austere notion o…
The Metabolic Syndrome and Its Relationship to Hypertensive Target Organ Damage
2007
High blood pressure is often associated with various metabolic abnormalities, including abdominal obesity, dyslipidemia, elevated plasma glucose, and insulin resistance, which are the main features of the metabolic syndrome. The metabolic syndrome is extremely common worldwide. This high prevalence is of considerable concern because several studies suggest that the metabolic syndrome carries an increased risk for cardiovascular events. Several lines of evidence seem to indicate that the metabolic syndrome is associated with an increased prevalence of preclinical cardiovascular and renal changes, such as left ventricular hypertrophy, microalbuminuria, impaired aortic elasticity, and early ca…
The Slow Adoption Rate of Software Robotics in Accounting and Payroll Services and the Role of Resistance to Change in Innovation-Decision Process
2022
Robotic process automation (RPA) has by now for years been viewed as a disruptive innovation that will have a significant impact on accounting, HR and payroll services, and yet the rate of adopting the innovation has not reached a level anticipated in past predictions. As several elements have a negative impact on the organization’s rate of adopting RPA, passive resistance to change has a significant impact in the form of constant dithering. Resistance to change can emerge at any stage of the Innovation-Decision process and fluctuate throughout the continued adoption, causing wasted investments, capabilities and resources. peerReviewed
Bakteriofāgu terapijas iespējas
2016
Pārmērīga antibakteriālu līdzekļu lietošana veicina epidēmijas mēroga bakteriālās rezistences pieaugumu attīstītajās un attīstības valstīs. Bakteriālās rezistences pieaugums atdzīvina interesi par alternatīvām antibakteriālām terapijām. Viena no tām iesaista bakteriofāgus – vīrusus, kuriem piemīt spējas inficēt un vairoties baktēriju saimniekšūnās veicinot to lizēšanu. Ir plaši dokumentēta fāgu veikta vairāku rezistentu baktēriju izskaušana, tomēr nav skaidrs, caur kādiem mehānismiem tā tiek panākta. Tas apgrūtina regulējošo iestāžu atļauju izsniegšanu, lai ieviestu bakteriofāgu terapiju klīniskajā praksē. Bakalaura darba mērķis bija noskaidrot veselības aprūpes speciālistu (ārstu) viedokli…
Distinct bhaplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe
2015
Abstract: Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplo…