Search results for "ROMARIN"

showing 4 items of 4 documents

Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver

2001

The effects of a water-soluble extract (WSE) of rosemary and its purified antioxidant rosmarinic acid (RA) on xenobiotic metabolizing enzymes (XME) were studied in rat liver after dietary administration. The modulation of phase I enzymes such as cytochrome P450 (CYP) 1A, 2B, 2E1, 3A, and phase II enzymes such as glutathione S-transferase (GST), quinone reductase (QR) and UDP-glucuronosyltransferase (UGT) was evaluated by measuring enzyme activities with specific substrates. Protein levels of CYPs and rGST A1/A2, A3/A5, M1, M2 and P1 were measured using antibodies in Western blots. Caffeic acid was also studied because it results from RA biotransformation in rat after oral administration. Ma…

MaleAntioxidantmedicine.medical_treatment[SDV]Life Sciences [q-bio]ReductaseToxicologychemistry.chemical_compoundCytosol0302 clinical medicine[SDV.IDA]Life Sciences [q-bio]/Food engineeringCaffeic acidChromatography High Pressure LiquidComputingMilieux_MISCELLANEOUSchemistry.chemical_classification0303 health sciencesbiologyRosmarinic acidOrgan SizeGeneral Medicine[SDV.IDA] Life Sciences [q-bio]/Food engineeringStimulation Chemical3. Good health[SDV] Life Sciences [q-bio]LiverBiochemistry030220 oncology & carcinogenesisMicrosomes Liver[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringImmunoblottingDepsidesdigestive systemFlavonesXenobiotics03 medical and health sciencesmedicineAnimals[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringRats Wistar030304 developmental biologyFlavonoidsLamiaceaePlant ExtractsTerpenesBody WeightROMARINCytochrome P450GlutathioneDietRatsEnzymechemistryCinnamatesbiology.proteinRATSpectrophotometry UltravioletBiomarkersFood Science
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Induction of cytochrome P450 and/or detoxication enzymes by various extracts or rosemary: description of specific patterns

2001

The ability of rosemary to modulate cytochrome P450 (CYP) and detoxication enzymes in rat liver was evaluated by comparing the effects of dried leaves and leaf extracts with different chemical compositions: essential oil (EO) containing monoterpenes, a dichloromethane extract (DCME) containing phenolic diterpenes and a water-soluble extract (WSE) containing phenolic compounds such as rosmarinic acid and flavonoids. Chemical analyses were done in order to characterize the composition of extracts. Male Wistar rats received the leaves or extracts of rosemary in their diet at 0.5% (w/w) for 2 weeks. The effects of such treatments were evaluated for CYP (1A, 2B, 2E1), glutathione S-transferase (…

Male[SDV]Life Sciences [q-bio]ReductaseToxicologychemistry.chemical_compoundCytosol0302 clinical medicineCytochrome P-450 Enzyme System[SDV.IDA]Life Sciences [q-bio]/Food engineeringCYTOCHROME P 450AnticarcinogenComputingMilieux_MISCELLANEOUSchemistry.chemical_classificationGLUTATHIONE S-TRANSFERASE0303 health sciencesbiologyReverse Transcriptase Polymerase Chain ReactionChemistryRosmarinic acidOrgan SizeGeneral Medicine[SDV.IDA] Life Sciences [q-bio]/Food engineeringSpecific Pathogen-Free Organisms[SDV] Life Sciences [q-bio]LiverBiochemistryEnzyme Induction030220 oncology & carcinogenesisMicrosomes Liver[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringImmunoblottingChemopreventiondigestive system03 medical and health sciencesAnimals[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringRNA MessengerRats Wistar030304 developmental biologyLamiaceaePlant ExtractsBody WeightROMARINCytochrome P450GlutathioneUDP-GLUCURONOSYLTRANSFERASENAD(P)H Dehydrogenase (Quinone)RatsEnzymeMicrosomebiology.proteinRATFood Science
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Herbs and spices : natural sources of phenolic and terpenoid compounds with potential value in nutrition and health

2000

International audience

[SDV] Life Sciences [q-bio]TOXICOLOGIE[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering[SDV]Life Sciences [q-bio][SDV.IDA]Life Sciences [q-bio]/Food engineeringROMARINSANTE[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering[SDV.IDA] Life Sciences [q-bio]/Food engineeringComputingMilieux_MISCELLANEOUS
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Influence d’extraits naturels de romarin sur l’initiation de la cancérogenèse : recherche des mécanismes d’action

2001

Diplôme : Dr. d'Université; L’objectif de ce travail est d’étudier l’influence d’extraits de romarin sur l’étape d’initiation de la cancérogenèse ainsi que les mécanismes mis en jeu. Plusieurs extraits de romarin sont utilisés, notammen tun extrait contenant des diterpènes phénoliques (ED) et un extrait contenant des acides-phénols et des flavonoïdes (EHS). Dans un modèle d’hépatocancérogenèse induite par le benzo(a)pyrène (BaP), les deux extraits (ED et EHS) diminuent significativement la formation de foyers prénéoplasiques. L’utilisation de fractions subcellulaires de foie de rats traités avec les extraits ED et EHS, dans le test de Armes, a notamment permis de mettre en évidence une fort…

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]ROMARINPREVENTION DES MALADIES
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