Search results for "Recurrent"
showing 10 items of 256 documents
Sorafenib in advanced hepatocellular carcinoma
2008
none 25 BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Seconda…
Marginal hazard ratio estimates in joint frailty models for heart failure trials
2019
Abstract This work is motivated by clinical trials in chronic heart failure disease, where treatment has effects both on morbidity (assessed as recurrent non‐fatal hospitalisations) and on mortality (assessed as cardiovascular death, CV death). Recently, a joint frailty proportional hazards model has been proposed for these kind of efficacy outcomes to account for a potential association between the risk rates for hospital admissions and CV death. However, more often clinical trial results are presented by treatment effect estimates that have been derived from marginal proportional hazards models, that is, a Cox model for mortality and an Andersen–Gill model for recurrent hospitalisations. …
A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials
2021
In heart failure trials efficacy is usually proven by a composite endpoint including cardiovascular death (CVD) and recurrent heart failure hospitalisations (HFH), evaluated with time-to-first-event analysis based on a Cox model. As a considerable fraction of events is ignored that way, recurrent event[for full text, please go to the a.m. URL]
String Attractors and Infinite Words
2022
The notion of string attractor has been introduced by Kempa and Prezza (STOC 2018) in the context of Data Compression and it represents a set of positions of a finite word in which all of its factors can be “attracted”. The smallest size γ∗ of a string attractor for a finite word is a lower bound for several repetitiveness measures associated with the most common compression schemes, including BWT-based and LZ-based compressors. The combinatorial properties of the measure γ∗ have been studied in [Mantaci et al., TCS 2021]. Very recently, a complexity measure, called string attractor profile function, has been introduced for infinite words, by evaluating γ∗ on each prefix. Such a measure has…
Are Neural Networks Imitations of Mind?
2015
Artificial neural networks are often understood as a good way to imitate mind through the web structure of neurons in brain, but the very high complexity of human brain prevents to consider neural networks as good models for human mind;anyway neural networks are good devices for computation in parallel. The difference between feed-forward and feedback neural networks is introduced; the Hopfield network and the multi-layers Perceptron are discussed. In a very weak isomorphism (not similitude) between brain and neural networks, an artificial form of short term memory and of acknowledgement, in Elman neural networks, is proposed.
Design e narrazioni
2022
Il testo nasce dall’esigenza di mettere a fuoco le implicazioni cognitive, metodologiche e progettuali del concetto di narrazione, sempre più ricorrente nella nostra esperienza quotidiana soprattutto per le molteplici forme di comunicazione e di produzioni culturali che vi si ispirano; si tratta di un concetto che anche nella riflessione teorica e nella progettualità del design sta alimentando dimensioni fortemente innovative ed evolutive nella costruzione, comunicazione di significati, contenuti immateriali, esperienze e valori emozionali che si sovrappongono e s’intrecciano all’espressione tangibile e funzionale degli oggetti, degli artefatti comunicativi, degli spazi. Si propone un perco…
Diffusive neural network
2002
Abstract A non-connectionist model of a neuronal network based on passive diffusion of neurotransmitters is presented as an alternative to hard-wired artificial neural networks. Classic thermodynamical approach shows that the diffusive network is capable of exhibiting asymptotic stability and a dynamics resembling that of a chaotic system. Basic computational capabilities of the net are discussed based on the equivalence with a Turing machine. The model offers a way to represent mass-sustained brain functions in terms of recurrent behaviors in the phase space.
Non-recurrent laryngeal nerve coexisting with ipsilateral recurrent nerve: personal experience and literature review.
2011
Introduction. Non-recurrence and variations in ascending course of the recurrent laryngeal nerve (RLN) represent a risk factor for nerve injuries during thyroid surgery. Non-recurrent laryngeal nerve (NRLN) coexisting to recurrent nerve branch is a rare anatomyc anomaly. It could be a cause of nerve injuries during thyroidectomy. A systematic intraoperative nerve identification may allow an effectiveness prevention of iatrogenic injuries. Case report. We report one case of a young woman underwent to total thyroidectomy (TT) for papillary thyroid carcinoma (PTC) where we found a rare variation of the right inferior laryngeal nerve anatomy. We identified both right laryngeal nerve structures …
Number VII Behcet's disease (Adamantiades syndrome)
2006
Behçet's syndrome (BS; Adamantiades syndrome) is the association of the triple symptom complex of recurrent aphthous stomatitis (RAS) with genital ulceration, and eye disease (especially iridocyclitis) though a number of other systemic manifestations may also be seen. BS mainly affects young adult males, and there is an association with HLA-B5 and HLA-B51 (B5101). Features such as arthralgia and leucocytoclastic vasculitis suggest an immune-complex mediated basis, which is supported by finding circulating immune complexes and, although the antigen responsible is unidentified, heat shock proteins have been implicated. An inflammatory disorder, BS is now considered as a systemic vasculitis, c…
Heart Failure Occurrence: Mining Significant Patterns and 10 Days Early Prediction
2021
Electronic health records containing patient’s medical history, drug prescription, vital signs measurements, and many more parameters, are being frequently extracted and stored as unused raw data. On the other hand, machine learning and data mining techniques are becoming popular in the medical field, providing the ability to extract knowledge and valuable information from electronic health records along with accurately predicting future disease occurrence. This chapter presents a study on medical data containing vital signs recorded over the course of some years, for real patients suffering from heart failure. The first significant patterns that come along with heart failure occurrence are…