Search results for "Rota"

Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing muc…

2017

Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model. As well as prophylac…

Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children

2021

The gut microbiota has emerged as a key factor in the pathogenesis of intestinal viruses, including enteroviruses, noroviruses and rotaviruses (RVs), where stimulatory and inhibitory effects on infectivity have been reported. With the aim of determining whether members of the microbiota interact with RVs during infection, a combination of anti-RV antibody labeling, fluorescence-activated cell sorting and 16S rRNA amplicon sequencing was used to characterize the interaction between specific bacteria and RV in stool samples of children suffering from diarrhea produced by G1P[8] RV. The genera Ruminococcus and Oxalobacter were identified as RV binders in stools, displaying enrichments between …

Assessing the burden of viral co-infections in acute gastroenteritis in children: An eleven-year-long investigation.

2020

Abstract Background Acute gastroenteritis is an important cause of childhood morbidity and mortality worldwide. A number of pathogens are responsible for human acute gastroenteritis. The recent introduction of syndromic assays for the diagnosis of enteric infections, including a wide panel of enteric pathogens, has unveiled the frequency of mixed infections. This study was carried out to assess the burden of viral co-infections and the genetic diversity of the viruses detected in children hospitalized with acute gastroenteritis in Italy. Methods A total of 4161 stool samples collected from diarrheic children over 11 years, from January 2008 to December 2018, were investigated for the presen…

QuBiLS-MAS, open source multi-platform software for atom- and bond-based topological (2D) and chiral (2.5D) algebraic molecular descriptors computati…

2017

Background In previous reports, Marrero-Ponce et al. proposed algebraic formalisms for characterizing topological (2D) and chiral (2.5D) molecular features through atom- and bond-based ToMoCoMD-CARDD (acronym for Topological Molecular Computational Design-Computer Aided Rational Drug Design) molecular descriptors. These MDs codify molecular information based on the bilinear, quadratic and linear algebraic forms and the graph-theoretical electronic-density and edge-adjacency matrices in order to consider atom- and bond-based relations, respectively. These MDs have been successfully applied in the screening of chemical compounds of different therapeutic applications ranging from antimalarials…

Age-dependent control of collagen-dependent platelet responses by thrombospondin-1 : Comparative analysis of platelets from neonates, children, adole…

2021

Platelet function is developmentally regulated. Healthy neonates do not spontaneously bleed, but their platelets are hypo-reactive to several agonists. The mechanisms underlying immature platelet function in neonates are incompletely understood. This critical issue remains challenging for the establishment of age-specific reference ranges. In this study, we evaluated platelet reactivity of five pediatric age categories, ranging from healthy full-term neonates up to adolescents (11–18 years) in comparison to healthy adults (&gt

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

2020

This review updates current knowledge regarding the risk of viral infections, including COVID-19, in patients treated with cyclosporine. We also shortly refer to bacterial infections and parasitic infestations in patients treated with cyclosporin. Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatment of autoimmune skin diseases in dermatology, rheumatology, ophthalmology and nephrology, and in organ transplantation. A usual concern associated with immunosuppressive treatment is the potential risk of infections. Interestingly, several data indicate a relatively low risk of infections, especially viral infections, in patients receiving cyclosp…

2020

Background: We prospectively tested technical feasibility and clinical outcome of percutaneous ultrasound-guided tenotomy of long head of biceps tendon (LHBT). Methods: We included 11 patients (6 women; age: 73 ± 8.6 years) with symptomatic full-thickness rotator cuff tear and intact LHBT, in whom surgical repair was not possible/refused. After ultrasound-guided injection of local anesthetic, the LHBT was cut with a scalpel under continuous ultrasound monitoring until it became no longer visible. Pain was recorded before and at least six months after procedure. An eight-item questionnaire was administered to patients at follow-up. Results: A median of 4 tendon cuts were needed to ensure com…

An Illustration to Ælfric’s De temporibus anni in Ælfwine’s Prayerbook

2020

L'articolo esamina un diagramma contenuto nel manoscritto London, British Library, Cotton Titus D.xxvii+xxvi, generalmente noto come 'Ælfwine’s Prayerbook'. Il diagramma, che si trova al fol. 21 v , è stato in genere interpretato come una rota incompleta, o delle maree o dei venti (dal momento che contiene solo 4 dei canonici 12 venti della tradizione scientifica medievale). Una analisi comparativa e dettagliata delle caratteristiche del diagramma, tuttavia, mostra come l'ipotesi della rota delle maree sia da rigettare in favore della teoria di una rota ventorum. Inoltre, l'analisi dei testi contenuti nel manoscritto rivela una stretta connessione tra il diagramma e il De temporibus anni di…

Are we correctly measuring the rotational viscosity of heterogeneous bituminous binders?

2020

Modified bituminous binders allow asphalt technologists to design asphalt mixtures with superior performance. However, several recent studies highlighted that due to the complexity of these material, their characterisation can be challenging since common procedures used to characterise neat bitumen might not be adequate. For instance, during high temperature rotational viscosity testing of recycled tyre rubber modified binders (RTR-MB), a number of changes may occur to the sample leading to the here-defined sample stability which in turn provides misleading results. In this study the authors want to first provide a deeper understanding of this phenomenon by a numerical analysis using a besp…

1,5 – 3 gadus vecu bērnu sociālā adaptācija pirmsskolas izglītības iestādē, izmantojot kustību rotaļas

2022

Bakalaura darba nosaukums: 1,5 – 3 gadus vecu bērnu sociālā adaptācija pirmsskolas izglītības iestādē, izmantojot kustību rotaļas Darba autore: Līga Kauliņa Zinātniskā vadītāja: dr. paed., doc. Līga Āboltiņa Darba mērķis: Teorētiski izzināt un praksē pārbaudīt 1,5 – 3 gadus vecu bērnu sociālās adaptācijas norisi pirmsskolas izglītības iestādē Darba uzdevumi: 1. Analizēt teorētiskās nostādnes par sociālo adaptāciju. 2. Sniegt 1,5 – 3 gadus vecu bērnu pedagoģiski psiholoģisko raksturojumu. 3. Apzināt 1,5 – 3 gadus vecu bērnu sociālās adaptēšanās kritērijus. 4. Raksturot sociālās adaptācijas sekmēšanas metodes un paņēmienus. 5. Veikt izmēģinājuma darbību 1,5 – 3 gadus vecu bērnu sociālās adapt…