Search results for "S-N"
showing 10 items of 292 documents
Menores criados por sus abuelas. Mejora de la pautas de cuidado a menores en acogimiento familiar en familia extensa a través de un programa de inter…
2011
[EN] In this research we have tried to describe the fostering kinship with grandparents as an alternative to living together in cases in which parents cannot play or stop playing their roles of main caregivers of their own children. This diversity ranges from multiproblematical and risky families, in which the situations of neglect and unprotection of minors prevail, to the care of minors due to more normalized causes (like parents death, divorce, etc.) The impact of this family situation on grandparents requires an special attention, due to problems related to the restructuring of roles, i.e. turning grandparents into substitute parents. The prevention of the emergence of negative conseque…
The Ultimate Fate of Supercooled Liquids
2010
In recent years it has become widely accepted that a dynamical length scale {\xi}_{\alpha} plays an important role in supercooled liquids near the glass transition. We examine the implications of the interplay between the growing {\xi}_{\alpha} and the size of the crystal nucleus, {\xi}_M, which shrinks on cooling. We argue that at low temperatures where {\xi}_{\alpha} > {\xi}_M a new crystallization mechanism emerges enabling rapid development of a large scale web of sparsely connected crystallinity. Though we predict this web percolates the system at too low a temperature to be easily seen in the laboratory, there are noticeable residual effects near the glass transition that can account …
Growing length scales in a supercooled liquid close to an interface
2002
We present the results of molecular dynamics computer simulations of a simple glass former close to an interface between the liquid and the frozen amorphous phase of the same material. By investigating F_s(q,z,t), the incoherent intermediate scattering function for particles that have a distance z from the wall, we show that the relaxation dynamics of the particles close to the wall is much slower than the one for particles far away from the wall. For small z the typical relaxation time for F_s(q,z,t) increases like exp(Delta/(z-z_p)), where Delta and z_p are constants. We use the location of the crossover from this law to the bulk behavior to define a first length scale tilde{z}. A differe…
Classical and ab-initio molecular dynamic simulation of an amorphous silica surface
2001
We present the results of a classical molecular dynamic simulation as well as of an ab initio molecular dynamic simulation of an amorphous silica surface. In the case of the classical simulation we use the potential proposed by van Beest et al. (BKS) whereas the ab initio simulation is done with a Car-Parrinello method (CPMD). We find that the surfaces generated by BKS have a higher concentration of defects (e.g. concentration of two-membered rings) than those generated with CPMD. In addition also the distribution functions of the angles and of the distances are different for the short rings. Hence we conclude that whereas the BKS potential is able to reproduce correctly the surface on the …
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.
2017
The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…
Sports participation in France and Spain: An international comparison of voraciousness for sport
2020
International audience; The societal comparative approach used in this article to assess voraciousness for sport is based on local surveys. The global was studied at a local level, based on a lengthy process of harmonization of quantitative local surveys. The research is carried out in two countries that are geographically close, but quite different to each other: France and Spain. In an increasingly globalized world, the objective is to examine differences in the social uses of physical activities and sports (PAS) between the two populations, by explaining them with respect to the differences between these two societies as a whole. The social differentiations identified in the portfolio si…
A magnetic skyrmion as a non-linear resistive element - a potential building block for reservoir computing
2017
Inspired by the human brain, there is a strong effort to find alternative models of information processing capable of imitating the high energy efficiency of neuromorphic information processing. One possible realization of cognitive computing are reservoir computing networks. These networks are built out of non-linear resistive elements which are recursively connected. We propose that a skyrmion network embedded in frustrated magnetic films may provide a suitable physical implementation for reservoir computing applications. The significant key ingredient of such a network is a two-terminal device with non-linear voltage characteristics originating from single-layer magnetoresistive effects,…
The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments.
2011
The complexity in composition and function of the eukaryotic nucleus is achieved through its organization in specialized nuclear compartments. The Drosophila chromatin remodeling ATPase ISWI plays evolutionarily conserved roles in chromatin organization. Interestingly, ISWI genetically interacts with the hsrω gene, encoding multiple non-coding RNAs (ncRNA) essential, among other functions, for the assembly and organization of the omega speckles. The nucleoplasmic omega speckles play important functions in RNA metabolism, in normal and stressed cells, by regulating availability of hnRNPs and some other RNA processing proteins. Chromatin remodelers, as well as nuclear speckles and their assoc…
Intensity of GABA-evoked responses is modified by nitric oxide-active compounds in the subthalamic nucleus of the rat: a microiontophoretic study.
2009
We have previously described modulatory effects of nitric oxide (NO)-active drugs on subthalamic nucleus (STN) neurons. In this study, the effects of microiontophoretically applied NO-active compounds on GABA-evoked responses were investigated in subthalamic neurons extracellularly recorded from anesthetized rats: 45 of 62 cells were excited by S-nitroso-glutathione (SNOG), an NO donor, whereas 28 of 43 neurons were inhibited by N-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor. Nearly all neurons responding to SNOG and/or L-NAME showed significant inhibitory responses to the administration of iontophoretic GABA. In these cells, the changes induced by NO-active drugs in the magnitud…
Nitric oxide inhibits electrically active units in the rat pineal gland.
1997
Extracellular multiple unit recordings were performed in isolated rat pineal glands to determine a possible effect of nitric oxide (NO) on the spontaneous electrical activity of pinealocytes. Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly firing clusters (REG, 64%) and irregularly discharging clusters with periodically repeated bursts (RHY, 36%). The NO-donor sodium nitroprusside (SNP) reduced the discharge rate of the great majority of REG clusters and of all the RHY clusters examined. Moreover, the burst activity of RHY clusters was abolished. These results could be completely reproduced by using another NO-donor, S-nitroso-N-acet…