Search results for "S1"
showing 10 items of 755 documents
Enhanced In Situ Availability of Aphanizomenon Flos-Aquae Constituents Entrapped in Buccal Films for the Treatment of Oxidative Stress-Related Oral D…
2019
In recent years, the key role of oxidative stress in pathogenesis of oral diseases has been emphasized and the use of antioxidant agents has been encouraged. Aphanizomenon flos-aquae (AFA) is a unicellular blue-green alga with antioxidant and anti-inflammatory properties. The aim of this study was the formulation and characterization of mucoadhesive thin layer films loaded with AFA, finalized to the treatment of oxidative stress (OS)-related oral diseases. First, to enhance the bioavailability of AFA constituents, the raw food grade material was appropriately treated by a high frequency homogenization able to disrupt cell walls. Thus, Eudragit®
A Hardware and Secure Pseudorandom Generator for Constrained Devices
2018
Hardware security for an Internet of Things or cyber physical system drives the need for ubiquitous cryptography to different sensing infrastructures in these fields. In particular, generating strong cryptographic keys on such resource-constrained device depends on a lightweight and cryptographically secure random number generator. In this research work, we have introduced a new hardware chaos-based pseudorandom number generator, which is mainly based on the deletion of an Hamilton cycle within the $N$ -cube (or on the vectorial negation), plus one single permutation. We have rigorously proven the chaotic behavior and cryptographically secure property of the whole proposal: the mid-term eff…
ALMA full polarization observations of PKS1830-211 during its record-breaking flare of 2019
2020
We report Atacama Large Millimeter Array (ALMA) Band 6 full-polarization observations of the lensed blazar PKS 1830-211 during its record-breaking radio and gamma-ray flare in the spring of 2019. The observations were taken close to the peak of the gamma activity and show a clear difference in polarization state between the two time-delayed images. The leading image has a fractional polarization about three times lower than the trailing image, implying that significant depolarization occurred during the flare. In addition, we observe clear intra-hour variability of the polarization properties between the two lensed images, with a quasi-linear increase in the differential electric-vector pos…
Asynchronous L1 control of delayed switched positive systems with mode-dependent average dwell time
2014
Abstract This paper investigates the stability and asynchronous L 1 control problems for a class of switched positive linear systems (SPLSs) with time-varying delays by using the mode-dependent average dwell time (MDADT) approach. By allowing the co-positive type Lyapunov–Krasovskii functional to increase during the running time of active subsystems, a new stability criterion for the underlying system with MDADT is first derived. Then, the obtained results are extended to study the issue of asynchronous L 1 control, where “asynchronous” means that the switching of the controllers has a lag with respect to that of system modes. Sufficient conditions are provided to guarantee that the resulti…
Stabilization of positive switched systems with time-varying delays under asynchronous switching
2014
Published version of an article in the journal: International Journal of Control, Automation and Systems. Also available from the publisher at: http://dx.doi.org/10.1007/s12555-013-0486-x This paper investigates the state feedback stabilization problem for a class of positive switched systems with time-varying delays under asynchronous switching in the frameworks of continuous-time and discrete-time dynamics. The so-called asynchronous switching means that the switches between the candidate controllers and system modes are asynchronous. By constructing an appropriate co-positive type Lyapunov-Krasovskii functional and further allowing the functional to increase during the running time of ac…
A bi-allelic loss-of-function SARS1 variant in children with neurodevelopmental delay, deafness, cardiomyopathy, and decompensation during fever
2021
Aminoacyl-tRNA synthetases (aaRS) are ubiquitously expressed enzymes responsible for ligating amino acids to their cognate tRNA molecules through an aminoacylation reaction. The resulting aminoacyl-tRNA is delivered to ribosome elongation factors to participate in protein synthesis. Seryl-tRNA synthetase (SARS1) is one of the cytosolic aaRSs and catalyzes serine attachment to tRNASer . SARS1 deficiency has already been associated with moderate intellectual disability, ataxia, muscle weakness, and seizure in one family. We describe here a new clinical presentation including developmental delay, central deafness, cardiomyopathy, and metabolic decompensation during fever leading to death, in a…
Integration of fuzzy logic and image analysis for the detection of gullies in the Calhoun Critical Zone Observatory using airborne LiDAR data
2017
Abstract The entire Piedmont of the Southeastern United States, where the Calhoun Critical Zone Observatory (CCZO) is located, experienced one of the most severe erosive events of the last two centuries. Forested areas were cleared to cultivate cotton, tobacco, and other crops during the nineteenth and early twentieth century and these land use changes, together with intense rainfalls, initiated deep gullying. An accurate mapping of these landforms is important since, despite some gully stabilization and reforestation efforts, gullies are still major contributors of sediment to streams. Mapping gullies in the CCZO area is hindered by the presence of dense canopy, which precludes the identif…
Fingerprint Quality Evaluation in a Novel Embedded Authentication System for Mobile Users
2015
The way people access resources, data and services, is radically changing using modern mobile technologies. In this scenario, biometry is a good solution for security issues even if its performance is influenced by the acquired data quality. In this paper, a novel embedded automatic fingerprint authentication system (AFAS) for mobile users is described. The goal of the proposed system is to improve the performance of a standard embedded AFAS in order to enable its employment in mobile devices architectures. The system is focused on the quality evaluation of the raw acquired fingerprint, identifying areas of poor quality. Using this approach, no image enhancement process is needed after the …
Mecanismos Bioquímicos y Moleculares de la Neurodegeneración en la Enfermedad de Alzheimer
2023
La enfermedad de Alzheimer se caracteriza por la presencia de placas amiloideas, hiperfosforilación de la proteína TAU e incremento de la inflamación cerebral. El uso de modelos animales de experimentación, como APP/PS1 (proteína precursora de amiloide/presenilina 1), permite observar los cambios producidos tanto a nivel de bioquímico como de biología molecular. Las células encargadas de intervenir en el proceso inflamatorio cerebral son los astrocitos y la microglía. Los resultados de esta tesis nos indican que los cambios en las quimiocinas y los receptores de quimiocinas son importantes debido a la implicación que podrían tener en la inflamación relacionada con la enfermedad de Alzheimer…
Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts
2021
Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…