Search results for "S1"
showing 10 items of 755 documents
Agrīnā pirmsskolas vecuma bērnu labizjūtas attīstība
2018
Kvalifikācijas darba tēma ir “Agrīnā pirmsskolas vecuma bērnu labizjūtas attīstība”. Pētījuma mērķis ir izzināt 2-3 gadus vecu bērnu labizjūtas attīstības sekmēšanas iespējas vizuālās mākslas nodarbībās. Kvalifikācijas darba pirmajā nodaļā autore ir teorētiski analizējusi labizjūtas būtību kā arī 2-3 gadus vecu bērnu labizjūtas attīstības galvenos priekšnoteikumus. Šajā nodaļā ir rakstturota un teorētiski pētīta vizuālās mākslas nodarbību nozīme bērnu labizjūtas veicināšanā. Kvalifikācijas darba otrajā nodaļā autore ir veikusi empīrisku pētījumu, kurā ir iekļauta pētījuma metodoloģija, plāns, pētījuma organizēšana gaita, nodarbību kopums un pētījuma rezultātu analīze. Autore ir izstrādājusi…
Triterpenoid saponins from the cultivar “Green Elf” of Pittosporum tenuifolium
2021
Four oleanane-type glycosides were isolated from a horticultural cultivar “Green Elf” of the endemic Pittosporum tenuifolium (Pittosporaceae) from New Zealand: three acylated barringtogenol C glycosides from the leaves, with two previously undescribed 3-O-β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C, 3-O-β-d-galactopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C, and the known 3-O-β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→3)]-β-d-glucuronopyranosyl-21-O-angeloyl-28-O-acetylbarringtogenol C (Eryngioside L). From the roots, the known 3-O-β-d-glucopyra…
Experimental inhibition of nitric oxide increases Plasmodium relictum (lineage SGS1) parasitaemia.
2012
7 pages; International audience; Malaria is a widespread vector-borne disease infecting a wide range of terrestrial vertebrates including reptiles, birds and mammals. In addition to being one of the most deadly infectious diseases for humans, malaria is a threat to wildlife. The host immune system represents the main defence against malaria parasites. Identifying the immune effectors involved in malaria resistance has therefore become a major focus of research. However, this has mostly involved humans and animal models (rodents) and how the immune system regulates malaria progression in non-model organisms has been largely ignored. The aim of the present study was to investigate the role of…
The ATHENA X-ray Integral Field Unit (X-IFU)
2018
Event: SPIE Astronomical Telescopes + Instrumentation, 2018, Austin, Texas, United States.
Determination of pollutants with multixenobiotic -resistance inhibiting properties
1995
Abstract Recent evidence indicates that inherent presence of multixenobiotic resistance (MXR) mechanism represents a general biological defence mechanism for protection of organisms against both endogenous and environmental toxins. In aquatic organisms exposed to polluted waters, this P-170 glycoprotein pump also removes ‘new’ man-made toxic chemicals out of cells. Many chemical agents may alter the function of this fragile mechanism. A new class of compounds, referred to as ‘chemosensitizers’, deserve a top rank among environmentally-hazardous chemicals, since they block this basic natural defence mechanism. The authors measured the concentration of such MXR-inhibiting substances by two me…
Pharmacokinetic Characterization and External Evaluation of a Quantitative Framework of Sublingual Buprenorphine in Patients with an Opioid Disorder …
2020
Background: The aim of this analysis was to characterize the pharmacokinetics (PK) of sublingual buprenorphine (BUP) and its metabolites (buprenorphine glucuronide
Oxidative stress in preterm infants: Overview of current evidence and future prospects
2020
Preterm birth (PTB), defined as parturition prior to 37 weeks of gestation, is the leading cause of morbidity and mortality in the neonatal population. The incidence and severity of complications of prematurity increase with decreasing gestational age and birthweight. The aim of this review study is to select the most current evidence on the role of oxidative stress in the onset of preterm complication prevention strategies and treatment options with pre-clinical and clinical trials. We also provide a literature review of primary and secondary studies on the role of oxidative stress in preterm infants and its eventual treatment in prematurity diseases. We conducted a systematic literature s…
Stability and l1-gain analysis for positive 2D T–S fuzzy state-delayed systems in the second FM model
2014
This paper considers the problems of delay-dependent stability and l"1-gain analysis for a class of positive two-dimensional (2D) Takagi-Sugeno (T-S) fuzzy linear systems with state delays described by the second FM model. Firstly, the co-positive type Lyapunov function method is applied to establish sufficient conditions of asymptotical stability for the addressed positive 2D T-S fuzzy system. Then, the l"1-gain performance analysis for the positive 2D T-S fuzzy delayed system is studied. All the obtained results are formulated in the form of linear matrix inequalities (LMIs) which are computationally tractable. Finally, an illustrative example is given to verify the effectiveness of the p…
BBS1 Mutations in a Wide Spectrum of Phenotypes Ranging From Nonsyndromic Retinitis Pigmentosa to Bardet-Biedl Syndrome
2012
OBJECTIVE: To investigate the involvement of the Bardet-Biedl syndrome (BBS) gene BBS1 p.M390R variant in nonsyndromic autosomal recessive retinitis pigmentosa (RP). METHODS: Homozygosity mapping of a patient with isolated RP was followed by BBS1 sequence analysis. We performed restriction fragment length polymorphism analysis of the p.M390R allele in 2007 patients with isolated RP or autosomal recessive RP and in 1824 ethnically matched controls. Patients with 2 BBS1 variants underwent extensive clinical and ophthalmologic assessment. RESULTS: In an RP proband who did not fulfill the clinical criteria for BBS, we identified a large homozygous region encompassing the BBS1 gene, which carrie…
Proteomic analysis of tyrosine phosphorylation induced by exogenous expression of oncogenic kinase fusions identified in lung adenocarcinoma.
2021
Kinase fusions are considered oncogenic drivers in numerous types of cancer. In lung adenocarcinoma 5-10% of patients harbor kinase fusions. The most frequently detected kinase fusion involves the Anaplastic Lymphoma Kinase (ALK) and Echinoderm Microtubule-associated protein-Like 4 (EML4). In addition, oncogenic kinase fusions involving the tyrosine kinases RET and ROS1 are found in smaller subsets of patients. In this study, we employed quantitative mass spectrometry-based phosphoproteomics to define the cellular tyrosine phosphorylation patterns induced by different oncogenic kinase fusions identified in patients with lung adenocarcinoma. We show that exogenous expression of the kinase fu…