Search results for "S1"
showing 10 items of 755 documents
The untranslated region of exon 2 of the human neuronal nitric oxide synthase (NOS1) gene exerts regulatory activity.
2007
Expressional dysregulation of the human neuronal nitric oxide synthase (NOS1) gene represents an important mechanism in the pathogenesis of certain neuronal disease states. The structure and regulation of the human NOS1 gene is highly complex based on cell type- and stimulus-dependent usage of multiple exon 1 variants. Here we demonstrate that the untranslated region of exon 2 exerts promoter and enhancer functions as well, facilitated in large part by cooperative interaction of two conserved adjacent CREB/AP-1 binding sites. In human neuronal A673 cells, NOS1 expression is stimulated by several compounds which act through these sites, but also stimulate the combined promoter region of exon…
Mathematical modeling of a vehicle crash test based on elasto-plastic unloading scenarios of spring-mass models
2011
Published version of an article in the journal: The International Journal of Advanced Manufacturing Technology. Also available from the publisher on SpringerLink: htp://dx.doi.org/10.1007/s00170-010-3056-x This paper investigates the usability of spring which exhibit nonlinear force-deflection characteristic in the area of mathematical modeling of vehicle crash. We present a method which allows us to obtain parameters of the spring-mass model basing on the full-scale experimental data analysis. Since vehicle collision is a dynamic event, it involves such phenomena as rebound and energy dissipation. Three different spring unloading scenarios (elastic, plastic, and elasto-plastic) are covered…
Investigation of vehicle crash modeling techniques: theory and application
2013
Published version of an article in the journal: The International Journal of Advanced Manufacturing Technology. Also available from the publisher at: http://dx.doi.org/10.1007/s00170-013-5320-3 Creating a mathematical model of a vehicle crash is a task which involves considerations and analysis of different areas which need to be addressed because of the mathematical complexity of a crash event representation. Therefore, to simplify the analysis and enhance the modeling process, in this work, a brief overview of different vehicle crash modeling methodologies is proposed. The acceleration of a colliding vehicle is measured in its center of gravity—this crash pulse contains detailed informati…
Mixed l-/l1 fault detection observer design for positive switched systems with time-varying delay via delta operator approach
2014
Published version of an article in the journal: International Journal of Control, Automation and Systems. Also available from the publisher at: http://dx.doi.org/10.1007/s12555-013-0466-1 This paper investigates the problem of fault detection observer design for positive switched systems with time-varying delay via delta operator approach. A new fault sensitivity measure, called l-index, is proposed. The l- fault detection observer design and multi-objective l -/l1 fault detection observer design problems are addressed. Based on the average dwell time approach and the piecewise copositive type Lyapunov-Krasovskii functional method in delta domain, sufficient conditions for the existence of …
Robust H∞ sliding mode control with pole placement for a fluid power electrohydraulic actuator (EHA) system
2014
Published version of an article in the journal: International Journal of Advanced Manufacturing Technology. Also available from the publisher at: http://dx.doi.org/10.1007/s00170-014-5910-8 In this paper, we exploit the sliding mode control problem for a fluid power electrohydraulic actuator (EHA) system. To characterize the nonlinearity of the friction, the EHA system is modeled as a linear system with a system uncertainty. Practically, it is assumed that the system is also subject to the load disturbance and the external noise. An integral sliding mode controller is proposed to design. The advanced techniques such as the H ∞ control and the regional pole placement are employed to derive t…
Regulation of NOS expression in vascular diseases
2020
Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive molecule involved in the regulation of many cellular processes. One of the most prominent functions of NO is regulation of vasodilatation and thereby control of blood pressure. Most important for vascular tone is NOS3. Endothelial NOS3-generated NO diffuses into the vascular smooth muscle cells, activates the soluble guanylate cyclase resulting in enhanced cGMP concentrations and smooth muscle cell relaxation. However, more and more evidence exist that also NOS1 and NOS2 contribute to vascular function. We summarize the current knowledge about the regulation of NOS expression in the vasculature by tra…
Cloning and characterization of CSP37, a novel gene encoding a putative membrane protein of Candida albicans.
1997
In the course of an analysis of the functions and assembly of the cell wall of Candida albicans, we have cloned and characterized a gene, which we designated CSP37 (cell surface protein), encoding a 37-kDa polypeptide which is a membrane-associated protein. The gene was isolated by immunological screening of a DNA library constructed from mycelial cells with a polyclonal serum raised against cell walls of this morphology. Analysis of the nucleotide sequence of a corresponding genomic DNA fragment revealed a single open reading frame which encodes a predicted protein of 321 amino acids with no significant homology to others in the databases. Disruption of the CSP37 gene by the method describ…
Genetic polymorphism at the CSN1S1 gene in Girgentana dairy goat breed
2013
The aim of this work was to evaluate the variability of the αs1-casein locus in the endangered Girgentana dairy goat breed in order to define genetic improvement and a conservation program for this breed. The study was performed on 200 dairy goats by means of different PCR protocols. The most frequent alleles were A (0.590) and F (0.290) followed by B (0.065) and N (0.047). CSN1S1 E allele was identified with a very low frequency (0.008). The most common genotype was AF (0.365) followed by AA (0.340). The high frequency of the strong genotypes is associated with the production of milk with high fat and protein content and with optimal technological properties. In Girgentana goat breed, the …
Cover crops and pruning in Bobal and Tempranillo vineyards have little influence on grapevine nutrition
2016
ABSTRACT Cover crops may improve vineyard soil properties, grapevine nutrient status and berry composition, however, factors such as cover crop type, annual rainfall, climate and irrigation may change their effects on vineyards. From 2008 to 2011, the effects of a non-permanent cover crop and two pruning techniques on soil as well as vine nutrients and grapevine performance of two vineyards (cv. Tempranillo and cv. Bobal) were evaluated. For that purpose, two legumes were sown in inter-rows of hand-pruned vines in February and were tilled at flowering. Soil tillage, or cover cropping, was combined with either light pruning or severe pruning to study foliar nutrient variations. Soil N, P, K …
Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients
2021
Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…