Search results for "SAGE"
showing 10 items of 1373 documents
A micellar liquid chromatographic method for quality control of pharmaceutical preparations containing tricyclic antidepressants
2002
Micellar liquid chromatography methods for quality control of pharmaceutical preparations (capsules, pills, tablets, injections) containing the tricyclic antidepressants amineptine, amitriptiline, clomipramine, doxepin, imipramine, melitracen and nortriptyline alone or together with other CNS drugs like diazepam, medazepam and perphenazine are described. The methods using micellar solutions of cetyltrimethylammonium bromide as mobile phases and UV detection are rapid and reproducible. Due to the versatility of interactions in micellar liquid chromatography, it is possible determine highly hydrophobic compounds such as TCAs in a short time using mobile phases containing low organic solvent c…
Formation rates and protonation constants of azo dyes in a sodium dodecylsulphate micellar solution.
1991
The effects of a sodium dodecylsulphate micellar solution on the coupling rates of several diazotizated arylamines with N-(1-naphthyl)-ethylenediamine and the shifts in the protonation constants of the corresponding azo dyes are quantitatively studied. Aniline, o-, m- and p-aminobenzoic acids, ethyl p-aminobenzoate and several sulphadrugs are used, and the relationships among the intensity of the effects and the molecular structure of the diazonium ions and the dyes are discussed. A single simplified procedure for the determination of all the substances at pH = 1.3 +/- 0.3, where coupling is quickly completed to directly produce the protonated form of the dyes, is established and applied to…
Chemical gels of scleroglucan obtained by cross-linking with 1,w-dicarboxylic acids: Synthesis and characterization
2005
Chemical gels obtained by cross-linking reaction between scleroglucan and I, omega-dicarboxylic acids having a number of carbon atoms from 4 to 8 in the chain, have been prepared and characterised. The networks show properties correlated with the number of carbon atoms of the acid and with the molar ratio carboxylic acid/glucose unit of the polymer (r) employed in the cross-linking reaction. The diffusion of theophylline, chosen as model drug, through the swelled cross-linked polymers has been also investigated and it has enabled the diffusion coefficients of the drug to be calculated under different environmental conditions. The release profiles of theophylline from tablets prepared with t…
Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying
2020
Abstract The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In part…
pH-sensitive hydrogel based on a polyaspartamide derivative
2006
A pH-sensitive hydrogel was prepared by UV irradiation technique. Starting polymer was obtained from alpha,beta-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG). The PHG copolymer was cross-linked by UV irradiation in the presence of methacrylic acid (MA) to form a pH sensitive hydrogel. The cross-linked matrix shaped as microparticles was characterized by FT-IR spectrophotometry, XPS, X-ray diffraction, SEM and particle size distribution analyses. Moreover, to have information about water affinity of the prepared sample, swelling measurements were carried out in aqueous media mimicking some biological fluids. In order to employ the prepar…
FIA-Fluorimetric assembly for the determination of noradrenaline hydrochloride by a solid-phase reactor with immobilized hexacyanoferrate(III)
1997
An FIA assembly provided with immobilized hexacyanoferrate(III) is proposed for the fluorimetric determination of noradrenaline hydrochloride. The oxidative reagent is immobilized by means of a strong anion-exchange resin. The FIA manifold is very simple and the calibration graph is linear over the range 0.5–75mgl−1 noradrenaline hydrochloride with an r.s.d of 0.88% (17 replicates) and a sample throughput of 84h−1. Foreign compounds such as NaCl, sucrose, lactose and sodium sulfate caused no significant errors. The procedure is applied to the determination of noradrenaline in a medicinal formulation.
Hydrolysis of Phytic Acid by Microwave Treatment: Application to Phytic Acid Analysis in Pharmaceutical Preparations
1998
Abstract The acid hydrolysis of phytic acid in a Teflon reactor using a domestic microwave oven has been studied and compared with other reported procedures. In 0.44 M HCl quantitative hydrolysis was achieved with six heating stages of 2 min each. A lower yield was obtained with H 2 SO 4 and HNO 3 . The analytical use of this hydrolysis to determine phytic acid by indirect determination of phosphate has been demonstrated by analysis of three pharmaceutical formulations. No sample pretreatment other than obtaining a homogeneous suspension was necessary.
Le rôle des paysages urbains dans les choix d'itinéraires pédestres
2007
ACTI; International audience
iconographies paysagères et connaissances sur les paysages
2006
Les atlas de paysages ont été conçus dès 1994 comme outils possibles de connaissance paysagère. Leurs auteurs dressent l'inventaire des paysages régionaux et les analysent. Les prises de décision peuvent ainsi être facilitées par le traitement des informations contenues dans l'atlas. Les images (textes, photographies, cartes, croquis...), comme re-présentations des paysages qui les composent, révèlent et nourrissent des représentations sociales du paysage par la nature des informations divulguées et favorisent ainsi certaines démarches paysagères. Les images visuelles et textes contenus dans les atlas des paysages génèrent donc pour les acteurs de l'aménagement des représentations mentales …
Approche neuropsychologique du syndrome de Williams : Aspects-visuospatiaux
2009
International audience; Nous envisageons différentes dimensions de la cognition visuo-spatiale et visuo-constructive : le fonctionnement perceptif, les représentations spatiales et l’attention spatiale, la mémoire à court terme visuelle, les tâches visuo-constructives comme le dessin ou la construction de configurations avec des cubes. Nous discutons ensuite la question du traitement local et global des stimuli perceptifs et l’éventualité de déficits au niveau des fonctions exécutives qui pourraient expliquer les différences observées notamment dans le traitement global entre les personnes présentant un Syndrome de Williams (SW) et les personnes en développement normal. Enfin, les hypothèse…