Search results for "SAS"
showing 10 items of 2933 documents
Minimal unit vector fields
2002
We compute the first variation of the functional that assigns each unit vector field the volume of its image in the unit tangent bundle. It is shown that critical points are exactly those vector fields that determine a minimal immersion. We also find a necessary and sufficient condition that a vector field, defined in an open manifold, must fulfill to be minimal, and obtain a simpler equivalent condition when the vector field is Killing. The condition is fulfilled, in particular, by the characteristic vector field of a Sasakian manifold and by Hopf vector fields on spheres.
Comparative evaluation of critical factors in Delivering service quality gaps in the Bangladeshi banking industry
2018
Master's thesis Business Administration BE501 - University of Agder 2018 This research study aims to search for the gaps in the quality of the service for the customers in different types of banks in Bangladesh. The study will evaluate the service quality gaps regarding different critical factors based on the SERVQUAL model which is initially established by Parasuraman. The relative importance and necessity of these vital factors in the evaluation of overall service qualitygaps investigated in the dominance analysis technique. This study was run by the questions and interviews of bank customers to find their perceptions about the service quality of selected Bangladeshi banks (Mary & Karl 20…
The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium
2019
Microcystins are a family of chemically diverse hepatotoxins produced by distantly related cyanobacteria and are potent inhibitors of eukaryotic protein phosphatases 1 and 2A. Here we provide evidence for the biosynthesis of rare variants of microcystin that contain a selection of homo-amino acids by the benthic cyanobacterium Phormidium sp. LP904c. This strain produces at least 16 microcystin chemical variants many of which contain homophenylalanine or homotyrosine. We retrieved the complete 54.2 kb microcystin (mcy) gene cluster from a draft genome assembly. Analysis of the substrate specificity of McyB1 and McyC adenylation domain binding pockets revealed divergent substrate specificity …
Enhanced oxidative stress and increased mitochondrial mass during Efavirenz-induced apoptosis in human hepatic cells
2010
BACKGROUND AND PURPOSE Efavirenz (EFV) is widely used in the treatment of HIV-1 infection. Though highly efficient, there is growing concern about EFV-related side effects, the molecular basis of which remains elusive. EXPERIMENTAL APPROACH In vitro studies were performed to address the effect of clinically relevant concentrations of EFV (10, 25 and 50 mu M) on human hepatic cells. KEY RESULTS Cellular proliferation and viability were reduced in a concentration-dependent manner. Analyses of the cell cycle and several cell death parameters (chromatin condensation, phosphatidylserine exteriorization, mitochondrial proapoptotic protein translocation and caspase activation) revealed that EFV tr…
Transcription of genes in the biosynthetic pathway for fumonisin mycotoxins is epigenetically and differentially regulated in the fungal maize pathog…
2012
ABSTRACT When the fungal pathogen Gibberella moniliformis (anamorph, Fusarium verticillioides ) colonizes maize and maize-based products, it produces class B fumonisin (FB) mycotoxins, which are a significant threat to human and animal health. FB biosynthetic enzymes and accessory proteins are encoded by a set of clustered and cotranscribed genes collectively named FUM, whose molecular regulation is beginning to be unraveled by researchers. FB accumulation correlates with the amount of transcripts from the key FUM genes, FUM1 , FUM21 , and FUM8 . In fungi in general, gene expression is often partially controlled at the chromatin level in secondary metabolism; when this is the case, the deac…
Paraugu sagatavošanas metodes optimizācija farmaceitisko savienojumu noteikšanai notekūdens paraugos
2021
Paraugu sagatavošanas metodes optimizācija farmaceitisko savienojumu noteikšanai notekūdens paraugos. Šukajeva V., zinātniskā vadītāja Mag. ķīm. Ikkere L.E. Bakalaura darbs, 59 lpp., 11 attēli, 16 tabulas, 37 literatūras avoti, 1 pielikums. Latviešu valodā. Bakalaura darba ietvaros tika veikta literatūras avotu izpēte par uz notekūdeņiem balstītu epidemioloģiju, Latvijā izplātītākiem farmaceitiski aktīviem savienojumiem, populācijas biomarķieriem un farmaceitisko savienojumu noteikšanas tendencēm ūdens matricās. Klasiskā SPE metode tika optimizēta 56 farmaceitiski aktīvo savienojumu noteikšanai notekūdens paraugos. SPE metodes optimizēšanai tika salīdzinātās Oasis® HLB un dažādas Strata™ ko…
Chromatin remodeling regulation by small molecules and metabolites.
2010
The eukaryotic genome is a highly organized nucleoprotein structure comprising of DNA, histones, non-histone proteins, and RNAs, referred to as chromatin. The chromatin exists as a dynamic entity, shuttling between the open and closed forms at specific nuclear regions and loci based on the requirement of the cell. This dynamicity is essential for the various DNA-templated phenomena like transcription, replication, and repair and is achieved through the activity of ATP-dependent chromatin remodeling complexes and covalent modifiers of chromatin. A growing body of data indicates that chromatin enzymatic activities are finely and specifically regulated by a variety of small molecules derived f…
Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
2003
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
Pedagogy and moral in the Age of Enlightenment: the French writers and its reception in Spain
2002
El debate sobre la educación en la España en el siglo XVIII estuvo estrechamente relacionado con los planteamientos pedagógicos europeos, a través de lecturas y traducciones de numerosas obras, en particular francesas, cuyo influjo no siempre ha sido analizado con detenimiento. En este artículo se estudia la obra y la recepción en España de tres célebres escritoras francesas sobre moral y educación, Mme D’Épinay, Mme Le Prince de Beaumont y Mme de Genlis. A través de múltiples indicios (traducciones, reseñas en la prensa, suscripciones, citas, opiniones de lectores, expedientes de censura), se ponen de relieve las complejas formas de apropiación y las lecturas diversas e incluso opuestas qu…
Arbuscular mycorrhizal fungi influence host infection during epidemics in a wild plant pathosystem
2022
SummaryWhile pathogenic and mutualistic microbes are ubiquitous across ecosystems and often co-occur within hosts, how they interact to determine patterns of disease in genetically diverse wild populations is unknown.To test whether microbial mutualists provide protection against pathogens, and whether this varies among host genotypes, we conducted a field experiment in three naturally-occurring epidemics of a fungal pathogen, Podosphaera plantaginis, infecting a host plant, Plantago lanceolata, in the Åland Islands, Finland. In each population, we collected epidemiological data on experimental plants from six allopatric populations that had been inoculated with a mixture of mutualistic arb…