Search results for "SLI"
showing 10 items of 1729 documents
Muskuļu noslodze transportēšanas cauruļvadu apkalpošanas un remonta dienesta darbiniekiem. Preventīvie pasākumi.
2016
Maģistra darba nosaukums ir „Muskuļu noslodze transportēšanas cauruļvadu apkalpošanas un remonta dienesta darbiniekiem. Preventīvie pasākumi”. Darba autore ir Kristīne Kluša. Darba zinātniskais vadītājs: profesors, Dr.chem. Arturs Vīksna. Darbs ir izklāstīts uz 111 lpp., ietver 93 attēlus, 1 tabulu, 9 pielikumus, izmantoti 62 literatūras avoti. Maģistra darba pētījums sastāv no četrām galvenajām daļām. Pirmajā daļā ir veikts gan latviešu, gan ārzemju literatūras detalizēts apskats un tās kritisks izvertējums atbilstoši iepriekšminētajai maģistra darba tēmai. Otrajā daļā ir aprakstītas pētījumā izmantotās metodes (elektromiogrāfija, kustību analizators un RULA metodika kustību analīzei). Tre…
"Mitä useampi kokki, sitä huonompi soppa" : Maalaisliiton sanomalehdistön suhtautuminen kolmen suuren hallitusyhteistyöhön vuosina 1945-48
1999
Maalaisliiton/Keskustan kunta ja kuntalaisuus liikkeessä? : käsitehistoriallinen näkökulma Maalaisliiton/Keskustan kuntapoliittisiin asiakirjoihin 19…
2014
Tutkimukseni tarkoituksena on selvittää, mikä on Maalaisliiton/Keskustan kunta- ja kuntalaisuuskäsitys. Tarkastelen työssäni kunnan ja kuntalaisuuden saamia merkityksiä käsitehistoriallisesta näkökulmasta. Tutkimukseni teoriatausta rakentuu Reinhart Koselleckin ajatuksiin käsitehistoriasta. Pro-gradu tutkielman aineisto koostuu Maalaisliiton/Keskustan kuntapoliittisista ohjelmista. Kunta- ja kuntalaisuus ovat saaneet ohjelmissa uusia sisältöjä ja merkityksiä, vaikka tietyt perusasiat säilyvät aina 1940- luvun lopulta 2008 vuoden ohjelmaan saakka. Aineistoni osoittaa, että käsitteiden ympärillä on havaittavissa poliittista kamppailua. Tämä ilmenee esimerkiksi kunta- valtiosuhteen kautta. Puo…
Consensus document of an expert group from the Spanish Society of Arteriosclerosis (SEA) on the clinical use of nuclear magnetic resonance to assess …
2020
The assessment and prevention of cardiovascular risk (CVR) that persists in patients with dyslipidaemia despite treatment and achievement of goals specific to the plasma concentration of cholesterol linked to low density (c-LDL) is a clinical challenge today, and suggests that conventional lipid biomarkers are insufficient for an accurate assessment of CVR. Apart from their lipid content, there are other lipid particle characteristics. The results of this study show that there are a number of lipoprotein compounds that determine atherogenic potential and its influence on the CVR. However, such additional characteristics cannot be analysed by the techniques commonly used in clinical laborato…
An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
2018
In recent years, obesity and metabolic syndrome (MetS) have become a growing problem for public health and clinical practice, given their increased prevalence due to the rise of sedentary lifestyles and unhealthy eating habits. Thanks to animal models, basic research can investigate the mechanisms underlying pathological processes such as MetS. Here, we describe the methods used to develop an experimental rabbit model of diet-induced MetS and its assessment. After a period of acclimation, animals are fed a high-fat (10% hydrogenated coconut oil and 5% lard), high-sucrose (15% sucrose dissolved in water) diet for 28 weeks. During this period, several experimental procedures were performed to…
Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes
2016
The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant ch…
Homozygous Familial Hypercholesterolemia in Spain Prevalence and Phenotype-Genotype Relationship
2016
Background— Homozygous familial hypercholesterolemia (HoFH) is a rare disease characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and extremely high risk of premature atherosclerotic cardiovascular disease. HoFH is caused by mutations in several genes, including LDL receptor ( LDLR ), apolipoprotein B ( APOB ), proprotein convertase subtilisin/kexin type 9 ( PCSK9 ), and LDL protein receptor adaptor 1 ( LDLRAP1 ). No epidemiological studies have assessed HoFH prevalence or the clinical and molecular characteristics of this condition. Here, we aimed to characterize HoFH in Spain. Methods and Results— Data were collected from the Spanish Dyslipidemia Regist…
Lipidomic profiling identifies signatures of metabolic risk
2020
Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were…
New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration
2018
Appropriate positioning of new neurons in the brain promotes post-stroke functional recovery.
Glucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high fat diet
2016
Previous studies suggested that endogenous glucagon-like peptide 2 (GLP-2) is dispensable for the regulation of glucose homeostasis under normal conditions, while it can play a beneficial role in obesity conditions. The purpose of the present study was to investigate whether chronic treatment with Gly2-GLP-2, a stable analogue of GLP-2, can have an impact on glycaemic and lipid control in mice fed a high-fat diet (HFD), an animal model of human obesity and insulin resistance. HFD mice were treated once a day with Gly2-GLP-2 for 4 weeks. Body weight, food intake, fasting glucose, intraperitoneal glucose tolerance, insulin-induced glucose clearance, glucose-stimulated insulin secretion, β-cel…