Search results for "SPIO"

Elaboration of functionalized nanoparticles : applications as MRI contrast agent

2010

Spinel structured iron oxide nanoparticles open the way of biomedical applications of nanomaterials.Superparamagnetic properties of ten nanometer size crystallites permit to use them in diagnosis such as Magnetic Resonance Imaging (MRI).The aim of this work was to synthesize colloidal suspension of magnetite or maghemite (called USPIO for Ultrasmall SuperParamagnetic Iron Oxide) stable in physiological conditions (pH = 7.4 and [NaCl] = 0.15M).By classical co-precipitation method, UPSIO were synthesized with a mean crystallite size of 8 nm, with a specific surface area of 110 m².g-1 and an aggregate size of 20 nm. To stabilize these nano-objects, two ways were investigated. Electrostatic age…

Metallic core nano-devices as drug delivery systems

2014

STRATEGIE DI DIREZIONAMENTO ALL’EPATOCARCINOMA DI FARMACI ANTITUMORALI MEDIANTE SISTEMI NANOPARTICELLARI E DI VISUALIZZAZIONE IN CELLULE TUMORALI DEL…

Lo scopo di questo lavoro di tesi è stato quello di realizzare nuovi sistemi nanoparticellari per il direzionamento di farmaci o di agenti per l’imaging, potenzialmente utilizzabili per la terapia e/o per la diagnosi dell’epatocarcinoma (HCC), in particolare per quelle forme caratterizzate dall’overespressione del recettore di membrana degli epatociti ASGP-R o del recettore mitocondriale TSPO. In particolare, nel capitolo 2 sono state descritte la sintesi, la caratterizzazione chimico fisica, la capacità di internalizzazione cellulare e l’efficacia antitumorale di un nuovo sistema nanoparticellare, costituito da un dendrimero a struttura poli-amido-aminica (PAMAM) di quarta generazione, opp…

SPIONs embedded in polyamino acid nanogels to synergistically treat tumor microenvironment and breast cancer cells.

2018

Abstract The extremely complex tumor microenvironment (TME) in humans is the major responsible for the therapeutic failure in cancer nanomedicine. A new concept of disease-driven nanomedicine, henceforth named “Theranomics”, which attempts to target cancer cells and TME on the whole, represents an attractive alternative. Herein, a nanomedicine able to co-deliver doxorubicin and a tumor suppressive proteolytic protein such as collagenase-2 was developed. We successfully obtained superparamagnetic nanogels (SPIONs/Doco@Col) via the intermolecular azide-alkyne Huisgen cycloaddition. We demonstrated that a local ECM degradation and remodeling in solid tumors by means of collagenase-2 could enha…

Combining inulin multifunctional polycation and magnetic nanoparticles: Redox-responsive siRNA-loaded systems for magnetofection

2019

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are recognized as one of the most promising agents for theranostic applications. Among methods designed for siRNA delivery, magnetofection, that is, nucleic acid cell uptake under the influence of a magnetic field acting on magnetic nucleic acid vectors, is emerging as a unique approach to combining advantages such as strong improvement of the kinetics of the delivery process and the possibility of localizing nucleic acid delivery to an area where the magnetic field is applied. This paper reports on the preparation of siRNA loaded magnetoplexes&mdash

Metallic Core Nanocarriers for Multiple Cancer Targeting

2014

Finnish Cyber Security Strategy and Implementation

2015

Technical and automated solutions and information networks, which make planning, guidance and implementation possible fast and in a cost-efficient way, are widely used in Finnish information society. The flipside of this development is increased dependency on extensive and complicated technical systems and information networks. Failures in these systems or, for example, in their power supply may rapidly affect comprehensive security in society. Threats against security in society have become more multifaceted and, as a consequence, more complicated. Threats can no longer be divided clearly into military and non-military threats or internal and external threats; they are often interconnected…

Nanostrutture composite ad azione teranostica per il trattamento del cancro

2020

Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy

2013

The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…

Entry with two correlated signals : the case of industrial espionage and its positive competitive effects

2021

Recent advances in information and communication technologies have increased the incentives for firms to acquire information about rivals. These advances may have major implications for market entry because they make it easier for potential entrants to gather valuable information about, for example, an incumbent’s cost structure. However, little theoretical research has actually analyzed this question. This paper advances the literature by extending a one-sided asymmetric information version of Milgrom and Roberts’ (1982) limit pricing model. Here, the entrant is allowed access to an intelligence system (IS) of a certain precision that generates a noisy signal on the incumbent’s cost struct…