Search results for "Salt"

ChemInform Abstract: Cross-Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β-Amino Acids.

2009

The synthesis of enantiomerically pure, cyclic, gamma,gamma-difluorinated beta-amino acids with various ring sizes has been carried out with a cross-metathesis (CM) reaction being one of the key steps, followed by a Dieckmann-type condensation to bring about the cyclization. Subsequent catalytic hydrogenation under microwave irradiation with (-)-8-phenylmenthol as a chiral auxiliary led to the successful chemo- and diastereoselective chemical reduction of the resulting cyclic beta-enamino esters. The efficiency and scope of the CM reaction with different types of fluorinated imidoyl chlorides and unsaturated esters has also been studied in order to determine the optimal reaction conditions …

Integrated production of fresh water, sea salt and magnesium from sea water

2012

Seawater desalination is becoming an important source of fresh water in several countries all around the world. One of the main drawbacks of desalination processes, however, is related to the disposal of large quantities of concentrated brine, which is an always-present by-product of the process. An integrated production of fresh water and salts may be achieved using the discharge brine from a desalination plant as a feed for conventional salt ponds, with the advantages of using brine more concentrated than sea water and, in the case of thermal desalination plants, warmer than sea water. By doing so, the process is faster as a consequence of the enhancement of evaporation rate on the surfac…

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

2005

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated in order to control intrahepatic cholesterol and bile acid levels. Ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression. To retrace the evolution of the molecular mechanisms underlying CYP7A1 inhibition, we used a chicken hepatoma cell system that retains the ability to be induced by phenobarbital and other drugs. Whereas bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, mRNA expression of these nuclear receptors is unchanged by xenobiotics. Instead, drugs repress chicken hepatic nuclear factor 4alpha (HNF4alpha) transcript levels concomitant with a …

Non-Classical Transformation of Benzendiazonium Hydrogen Sulfates. Access to 1,3-Dimethylisochromeno[4,3-c]pyrazol-5(1H)-one, a Potential Benzodiazep…

2013

The compound 2-((1,3-dimethyl-1H-pyrazol-5-yl)(methyl)carbamoyl)benzene-diazonium hydrogen sulfate (10) was reacted with copper sulfate and sodium chloride, in the presence of ascorbic acid as reducing agent, to afford a mixture of the chlorinated epimers 4′-chloro-2,2′,5′-trimethyl-2′,4′-dihydrospiro[isoindoline-1,3′-pyrazol]-3-one (18) and (19), the epimers 4′-hydroxy-2,2′,5′-trimethyl-2′,4′-dihydrospiro[isoindoline-1,3′-pyrazol]-3-one (20) and (21), and N-(1,3-dimethyl-1H-pyrazol-5-yl)benzamide (22). Under the foregoing conditions, diazonium salt 10 affords neither the 2-chloro-N-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylbenzamide (23) nor the tricyclic derivative 24, the classical products…

Nesso di causalità

2009

ChemInform Abstract: Synthesis of Fluorinated and Non-Fluorinated Bicyclic Amidines Through Ring-Closing Metathesis.

2012

Condensation of unsaturated esters (I) and (VII) with 1,2-diamines proceeds in the presence of trimethylaluminum providing imidazolines (III) and (VIII) which are further allylated giving suitable dienes (V) and (IX).

ChemInform Abstract: An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis.

2014

Based on the title approach, the diastereoselective synthesis of potential peptidomimetics [(XI) and (XIV)] is described.

Eclogites and garnet pyroxenites: Similarities and differences

2010

Eclogites and garnet pyroxenites are genetically linked to basaltic precursors. Traditionally garnet pyroxenites are linked to fractionation of basaltic Magmas Over a range of mantle pressures and more recently they have been implicated in the genesis of ocean islands. in contrast eclogites are linked to the subduction of slab basalt and gabbro precursors which may be hydrothermally altered. Recently this subduction paradigm has been questioned. We present mineralogical, trace element and O isotopic data for eclogites and garnet pyroxenites that reveal some similarities but also important chemical and isotopic differences that support a distinct provenance (i.e., age and process). Continent…

Sodium release and saltiness perception in dairy product systems: influence of food composition and oral parameters

2010

International audience

Sodium release and saltiness perception in dairy product systems: influence of food composition and oral parameters

2010

 9. Wartburg Symposium on Flavour Chemistry and Biology (Eisenach (GER), April 13th-16th, 2010); International audience