Search results for "Sars-CoV-2"
showing 10 items of 1204 documents
Physical Exercise for Health and Performance Post-Pandemic COVID-19 Era, a Renewed Emphasis on Public Health
2022
After the period of forced quarantine due to the COVID-19 epidemic, the physiological principle of detraining became more evident than ever [...]
Fear of Coronavirus, Stress and Fear of Childbirth in Polish Pregnant Women during the COVID-19 Pandemic
2021
The COVID-19 pandemic is the largest pandemic of an aggressive coronavirus in the human population in the 21st century. The pandemic may have a negative emotional impact on pregnant women, causing fear and stress. Negative feelings during pregnancy later affect fear of childbirth. Our study aimed to determine the relationship between fear of COVID-19, stress and fear of childbirth. We assume that fear of COVID-19 will be a mediator of the relationship between perceived stress and fear of childbirth. A total of 262 Polish pregnant women participated in this study. Perceived Stress Scale (PSS-10), Fear of COVID-19 Scale (FOC-6) and Labour Anxiety Questionnaire (KLP II) were used in the study.…
Genetic regulation of iron homeostasis in sideropenic patients with mild COVID-19 disease under a new oral iron formulation: Lessons from a different…
2022
Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) needs iron to replicate itself. Coronaviruses are able to upregulate Chop/Gadd153 and Arg1 genes, consequently leading to CD8 lymphocytes decrease, degradation of asparagine and decreased nitric oxide (NO), thus impairing immune response and antithrombotic functions. Little is known about regulation of genes involved in iron metabolism in pauci symptomatic patients with COVID-19 disease or in patients with iron deficiency treated with sucrosomial iron. Methods: Whole blood was taken from the COVID-19 patients and from patients with sideropenic anemia, treated or not (control group) with iron supplementations. Enrolled …
SARS-CoV-2 infection in COVID-19 patients in Latvia
2022
Šī darba ietvaros tika pētīta SARS-CoV-2 infekcija COVID-19 pacientiem Latvijā, raksturojot vīrusa genoma klātbūtni un slodzi vairākos klīniskajos paraugos un antivielas dinamikā. Pētījumā iesaistīti 134 pacienti, kuriem bija detektēts SARS-CoV-2 RNS nazofaringeālājās iztriepēs ar RT-PĶR metodi, pirms hospitalizācijas. Tika ievākti COVID-19 pacientu nazofaringeālās iztriepes, fēces, urīns, asins plazma, PMBC SARS-CoV-2 genoma klātbūtnes un vīrusa slodzes noteikšanai, izmantojot RT-kPĶŖ metodi. Tika ievākti pacientu plazmas paraugi antivielu detektēšanai un raksturošanai dinamikā, izmantojot ELISA metodi. SARS-CoV-2 genoma sekvence visbiežāk tika detektēta nazofaringeālajās iztriepēs (100/13…
The profile of hospitalized Covid-19 patients and evaluation of Remdesivir effectiveness
2022
Remdesivir ir viens no potenciāli klīniski efektīviem medikamentiem COVID-19 infekcijas ārstēšanā, samazinot hospitalizācijas ilgumu un mortalitāti. Darba mērķis: Izvērtēt hospitalizēto pacientu profilu un remdesivir klīnisko efektivitāti. Materiāli un metodes: Retrospektīvais pētījums tika veikts Latvijas Infektoloģijas centra arhīvā. Tika analizēti 180 pacienti, kas dalījās divās grupās. Kontroles grupā bija 35 pacienti un tie nesaņēma remdesivir terapiju. Remdesivir grupas 145 pacienti saņēma šo medikamentu terapijā. Tika analizēti demogrāfiskie, epidemioloģiskie, laboratorie un klīniskie rādītāji, kā arī medikamenta efektivitāte. Nozīmīgākie rezultāti: Vidējais vecums remdesivir grupai …
The year 2021 in COVID-19 pandemic in children
2022
AbstractIn this article, the developments in the field of COVID-19 pandemic published in the Italian Journal of Pediatrics in 2021 are reflected. We describe progresses in SARS-CoV-2 transmission route, clinical presentation, diagnosis, treatment, and access to health care facilities in children. They led to substantial changes in the clinical approach.
Impact of COVID-19 Pandemic on Disease Control Status and Quality of Life of Patients with Acromegaly.
2022
Background and Objectives: Despite the best efforts of healthcare workers and the deployment of alternative healthcare delivery solutions through telemedicine, the pandemic has disrupted standard care for patients with chronic conditions. The long-lasting pandemic has also had a profound impact on the quality of life (QoL) of the majority of patients with chronic illnesses. The management of rare diseases has been particularly challenging. We aimed to evaluate the impacts that the long-lasting pandemic had on the disease control status and QoL in patients with acromegaly. Materials and Methods: Our prospective study included 34 patients from a national referral centre. The baseline SAGIT an…
The First Case of Haemophagocytic Lymphohistiocytosis Triggered by the Booster Dose of Anti-SARS-CoV-2 Vaccine in a Patient with β-Thalassemia
2022
Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening systemic hyperinflammatory disease, which can have several aetiologies. Clinical case: a 48-year-old woman affected by a transfusion-dependent β-thalassemia was hospitalized in our haematology unit presenting with intermittent fever, haepatosplenomegaly and pancytopenia, which developed a few days after the booster dose of anti-SARS-CoV-2 mRNA vaccine. The investigations performed during hospitalization led to a diagnosis of HLH and steroid therapy where IV dexamethasone was initiated and provided benefits. Conclusions: the severity of HLH mandates early treatment, but the management of patients…
Specific Recognition of the 5′-Untranslated Region of West Nile Virus Genome by Human Innate Immune System
2022
In the last few years, the sudden outbreak of COVID-19 caused by SARS-CoV-2 proved the crucial importance of understanding how emerging viruses work and proliferate, in order to avoid the repetition of such a dramatic sanitary situation with unprecedented social and economic costs. West Nile Virus is a mosquito-borne pathogen that can spread to humans and induce severe neurological problems. This RNA virus caused recent remarkable outbreaks, notably in Europe, highlighting the need to investigate the molecular mechanisms of its infection process in order to design and propose efficient antivirals. Here, we resort to all-atom Molecular Dynamics simulations to characterize the structure of th…
Development of lung on a chip model for SARS-CoV-2 research
2021
Kopš 2019. gada beigām pasauli plosa SARS-CoV-2 izraisītā COVID-19 pandēmija. Lai gan COVID-19 vakcīnas ir tikušas izstrādātas rekordlielā ātrumā, pandēmija ir akcentējusi nepieciešamību padziļināti pētīt koronavīrusus, kā arī sagatavoties nākotnes respiratorām infekcijām. Lai nodrošinātu ātru atbildi pret jaunām respiratorām infekcijām, ir jāpilnveido in vitro modeļi, kas ļautu ātrāk pārprofilēt esošās zāles un izstrādāt jaunas priekš šīm infekcijām. Ņemot vērā orgānu uz čipa sistēmu pielietošanu dažādu slimību pētniecībā, šajā bakalaura darbā tika izveidota plaušas uz čipa sistēma. Tajā tika optimizēta funkcionalizēšana, plūsma un šūnu uzsēšana. Tā tika raksturota ar imūnfluorescenci un 3…