Search results for "Sial"
showing 10 items of 626 documents
Walking a tightrope - as a next-of-kin to an adolescent or young adult with cancer facing eating difficulties
2022
Purpose: Eating difficulties cause reduced food intake and poor quality of life among adolescents and young adults (AYAs) with cancer. Therefore, next-of-kin eating support is crucial. The purpose of this study was to explore the lived experiences of being close to AYAs with cancer in the context of eating when they are at home between high-emetogenic chemotherapy (HEC) sessions. Method: In-depth interviews were conducted with 12 next-of-kin to AYAs (15–29 years old) with oncological or haematological diseases, treated with HEC. Van Manen’s hermeneutic-phenomenological approach guided the design. Results: The essential meaning of the next-of-kin experiences is reflected in the overarching t…
Hyvä ja huono johtajuus suomalaisessa pankkiorganisaatiossa
2017
Tämän tutkimuksen fokus on hyvässä ja huonossa johtajuudessa suomalaisessa pankkiorganisaatiossa. Tutkimuksen tarkoituksena on etsiä hyvän ja huonon johtajuuteen tekijöitä organisaation kolmella eri tasolla: ylimmässä johdossa, keskijohdossa ja alimmalla tasolla. Lisäksi tutkimuksen tarkoituksena oli selvittää, löytyykö organisaation eri tasoilla eroja tai yhtäläisyyksiä näkemyksistä hyvästä ja huonosta johtajuudesta. Teoreettisena viitekehys koostuu monista eri johtajuuden tunnetuista teorioista. Viitekehys on jaettu kahteen osaan: hyvän ja huonon johtajuuden teorioihin. Hyvän johtajuuden teoriat ovat johtajuuden tutkimuskentän merkittävimpiä teorioita, jotka tuovat eri näkökulmia johtajuu…
Calretinin/PSA-NCAM immunoreactive granule cells after hippocampal damage produced by kainic acid and DEDTC treatment in mouse.
2003
There is a dramatic increase in the number of lightly immunoreactive calretinin cells in the granular layer of the dentate gyrus of the mouse hippocampus 1 day after excitotoxic injury using kainic acid combined with the zinc chelator diethyldithiocarbamate. At 7 days after treatment, these cells are strongly immunoreactive for calretinin and for the polysialated form of the glycoprotein neural cell adhesion molecule (PSA-NCAM). The reexpression of calretinin and PSA-NCAM after treatment corresponds well with the loss of input from the damaged hilar mossy cells. These cells could be considered immature granule cells since they are immunoreactive to markers for immature cells such as PSA-NCA…
Luokasta utopiaan : Erik Olin Wrightin myöhäistuotannosta
2020
Katsausartikkelissa tarkastellaan yhdysvaltalaisen marxilaissosiologi Erik Olin Wrightin niin sanottuihin todellisiin utopioihin kohdistunutta tutkimusta. Artikkelissa avataan sekä sitä, kuinka Wrightin todellisen utopian käsite tulisi ymmärtää, että sitä, kuinka hänen oma utopiansa eli ”sosiaalinen sosialismi” voisi olla mahdollinen ja millaiset tosimaailman kokeilut hänen mukaansa ennakoivat ja prefiguroivat tätä utopiaa. Lisäksi artikkelissa eritellään Wrightin käsityksiä antikapitalismin strategioista ja näiden myötä siitä, millä tavalla sosiaalisen sosialismin utopia olisi saavutettavissa. Artikkeli keskittyy erityisesti kahteen Wrightin myöhäistuotannon teokseen – Envisioning Real Uto…
Uenighetsdramaturgier
2019
Hvordan kan samtidsteater bli arena, laboratorium og katalysator for «uenighetsfellesskaper» (Iversen, 2014)? I denne artikkelen drøfter jeg teatersituasjonens potensial for uenighetsfellesskap og ser uenighet i forestillinger i relasjon til uenighet om forestillinger før jeg analyserer to eksempler på «uenighetsdramaturgier». I de kontekstsensible analysene undersøker jeg hvordan publikumets interne uenighet kommer til uttrykk, og hvordan det dramaturgisk legges til rette for denne uenigheten.
ChemInform Abstract: Chemoenzymatic-Chemical Synthesis of a (2-3)-Sialyl T Threonine Building Block and Its Application to the Synthesis of the N-Ter…
2010
Protection of all functional groups of the carbohydrate portion of the chemoenzymatically synthesized sialyl T threonine ester 1 (R=R1 =H, R2 =tBu, Fmoc=9-fluorenylmethoxycarbonyl) and subsequent acidolysis of the tert-butyl ester afforded the building block 2 (R=Ac, R1 =Me, R2 =H). The latter is a useful tool in the solid-phase synthesis of the N-terminal sequence 3 of the leukemia-associated leukosialin.
A language socialisation perspective on Swedish immersion in Finland : Students, teachers, and parents as key actors
2022
Abstract This retrospective review applies a language socialisation perspective in examining the findings of a four-year research project on Swedish immersion in Finland. Findings from nine sub-studies within the project are reported with a point-of-view from three key actors’ (teachers, students, and parents) language socialisation processes. Results show that a special feature of immersion teacher socialisation is its continuous attention toward the additive multilingual nature of immersion education, which requires sustained attention to multilingual language use and development. Students in Swedish immersion are socialised into the use of multiple languages in school and act as socialis…
Polysialic acid can mediate membrane interactions by interacting with phospholipids
2009
Polysialic acid (polySia) is expressed on the surface of neural cells, neuroinvasive bacterial cells and several tumor cells. PolySia chains attached to NCAM can influence both trans interactions between membranes of two cells and cis interactions. Here, we report on the involvement of phospholipids in regulation of membrane interactions by polySia. The pH at the surface of liposomes, specific molecular area of phosphatidylcholine molecules, phase transition of DPPC bilayers, cyclic voltammograms of BLMs, and electron micrographs of phosphatidylcholine vesicles were studied after addition of polysialic acid free in solution. The results indicate that polySia chains can associate with phosph…
Biophysical Characterization of Polysialic Acid—Membrane Nanosystems
2019
Polysialic acid (polySia) is a long, membrane-bound, polyanionic polymer (with the degree of polymerization, DP, up to 400) of negatively charged sialic acid monomers. Biological roles of polySia are based on its ability to modulate repulsive and attractive interactions, and its ability to modulate membrane surface charge density, pH at the membrane surface, and membrane potentials. PolySia is used in anti-bacterial and anti-cancer therapies, and in neural tissue repair. Hydrophobically-modified polySia chains can form nano-structures (micelles or liposomes) with high stability and low toxicity for drug delivery. The analysis, based on the Goldman-Hodgkin-Katz equation, of transmembrane pot…
Liver Membrane Autoantibodies
1996
Publisher Summary This chapter includes the intensive efforts to standardize the assay, define associations with disease or clinical presentation, and characterize antigenic and biological properties of anti-liver membrane antibodies. The characterization of different target antigens on the hepatic plasma membrane shows a polyvalent and heterogenous humoral immune response against the liver surface. Liver membrane antibodies can induce liver cell damage in vitro, including dysfunction of the target antigen. Among the established liver membrane-related autoantigens, the asialoglycoprotein receptor (ASGPR) represents the only component of the hepatic plasma membrane that is fully characterize…