Search results for "Simulation."
showing 10 items of 4779 documents
Patient-specific simulation of the intrastromal ring segment implantation in corneas with keratoconus
2015
Purpose The purpose of this study was the simulation of the implantation of intrastromal corneal-ring segments for patients with keratoconus. The aim of the study was the prediction of the corneal curvature recovery after this intervention. Methods Seven patients with keratoconus diagnosed and treated by implantation of intrastromal corneal-ring segments were enrolled in the study. The 3D geometry of the cornea of each patient was obtained from its specific topography and a hyperelastic model was assumed to characterize its mechanical behavior. To simulate the intervention, the intrastromal corneal-ring segments were modeled and placed at the same location at which they were placed in the s…
El diàleg paradigmàtic en Educació Social: la simulació com una manera d'ensenyar i aprendre en les aules universitàries
2012
El text presenta una pràctica de simulació a l'aula, realitzada -en els últims anys- amb estudiants que han cursat l'assignatura de 'Pedagogia Social' a la Diplomatura d'Educació Social i en la Llicenciatura de Pedagogia (ara Graus), a la Facultat de Ciències de l'Educació de la Universitat de Santiago de Compostel la. Amb un enfocament didàctic innovador, en què els alumnes adquireixen un protagonisme directe en els processos d'ensenyament-aprenentatge que es proposen, els seus plantejaments metodològics es projecten en un 'diàleg paradigmàtic' que pren com a referència els tres models de racionalitat teòrica (teories) als que sol remetre la Pedagogia-Educació Social: tecnològic, interpret…
Assessment of University Students’ Critical Thinking: Next Generation Performance Assessment
2019
Following employers’ criticisms and recent societal developments, policymakers and educators have called for students to develop a range of generic skills such as critical thinking (“twenty-first c...
Performative Architecture: New Semantic for New Shapes?
2008
Two innovations have more deeply changed the building process: the operational continuity of the design and construction phases and the software allowing not only the representation but also the autonomous creation of complex shapes never before thought, just because they could not be represented. This last innovation introduce to a "Performative Architecture" that addresses to emerge a new kind of architecture. Building performances (structural, environmental, energetic) are guiding design principles, adopting new building performance-based priorities for the design of cities, buildings and landscape. This emerging architecture places broadly defined performance above form making; It utili…
Intravascular pillars and pruning in the extraembryonic vessels of chick embryos.
2010
To investigate the local mechanical forces associated with intravascular pillars and vessel pruning, we studied the conducting vessels in the extraembryonic circulation of the chick embryo. During the development days 13-17, intravascular pillars and blood flow parameters were identified using fluorescent vascular tracers and digital time-series video reconstructions. The geometry of selected vessels was confirmed by corrosion casting and scanning electron microscopy. Computational simulations of pruning vessels suggested that serial pillars form along pre-existing velocity streamlines; blood pressure demonstrated no obvious spatial relationship with the intravascular pillars. Modeling a Re…
Semiflexible macromolecules in quasi-one-dimensional confinement: Discrete versus continuous bond angles
2015
The conformations of semiflexible polymers in two dimensions confined in a strip of width D are studied by computer simulations, investigating two different models for the mechanism by which chain stiffness is realized. One model (studied by molecular dynamics) is a bead-spring model in the continuum, where stiffness is controlled by a bond angle potential allowing for arbitrary bond angles. The other model (studied by Monte Carlo) is a self-avoiding walk chain on the square lattice, where only discrete bond angles (0° and ±90°) are possible, and the bond angle potential then controls the density of kinks along the chain contour. The first model is a crude description of DNA-like biopolymer…
Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristi…
2015
ABSTRACT: Disintegration of oral solid dosage forms is a prerequisite for drug dissolution and absorption and is to a large extent dependent on the pressures and hydrodynamic conditions in the solution that the dosage form is exposed to. In this work, the hydrodynamics in the PhEur/USP disintegration tester were investigated using computational fluid dynamics (CFD). Particle image velocimetry was used to validate the CFD predictions. The CFD simulations were performed with different Newtonian and non-Newtonian fluids, representing fasted and fed states. The results indicate that the current design and operating conditions of the disintegration test device, given by the pharmacopoeias, are n…
Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach
2022
Vitamin D’s role in combating the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus causing COVID-19, has been established in unveiling viable inhibitors of COVID-19. The current study investigated the role of pre and pro-vitamin D bioactives from edible mushrooms against Mpro and PLpro proteases of SARS-CoV-2 by computational experiments. The bioactives of mushrooms, specifically ergosterol (provitamin D2), 7-dehydrocholesterol (provitamin-D3), 22,23-dihydroergocalciferol (provitamin-D4), cholecalciferol (vitamin-D3), and ergocalciferol (vitamin D2) were screened against Mpro and PLpro. Molecular docking analyses of the generated bioactive protease complexes unr…
Prediction of tyrosinase inhibition activity using atom-based bilinear indices.
2007
A set of novel atom-based molecular fingerprints is proposed based on a bilinear map similar to that defined in linear algebra. These molecular descriptors (MDs) are proposed as a new means of molecular parametrization easily calculated from 2D molecular information. The nonstochastic and stochastic molecular indices match molecular structure provided by molecular topology by using the kth nonstochastic and stochastic graph-theoretical electronic-density matrices, M(k) and S(k), respectively. Thus, the kth nonstochastic and stochastic bilinear indices are calculated using M(k) and S(k) as matrix operators of bilinear transformations. Chemical information is coded by using different pair com…
Fragment- and negative image-based screening of phosphodiesterase 10A inhibitors.
2019
A novel virtual screening methodology called fragment- and negative image-based (F-NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A-specific small-molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F-NiB combines features from both fragment-based drug discovery and negative image-based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein-bound ligand(s) are seamlessly combined with the negative image of the target's ligand-binding cavity. This cavity- and fragment-based hybrid model, namely its shape and electr…