Search results for "Socio-cultural"

showing 10 items of 227 documents

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis o…

2018

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF…

AdultMaleDiabetes mellituLUNG SAFEOrgan Dysfunction Scoreshumanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Socio-culturaleOrgan Dysfunction ScoreDiabetes ComplicationsDiabetes mellituspuntuaciones de disfunción orgánicaRisk FactorsDiabetes Complicationestudios prospectivosHumansfactores de riesgoProspective StudiesHospital MortalityHypoxiamediana edadAcute hypoxemic respiratory failureAgedRespiratory Distress SyndromeancianoAcute respiratory distress syndromeResearchRespirationrespiraciónRespiratory Distress Syndrome Adultlcsh:Medical emergencies. Critical care. Intensive care. First aidlcsh:RC86-88.9Middle AgedRespiration Artificialinsuficiencia respiratoriaAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFEProspective StudieArtificialAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFE; Aged; Diabetes Complications; Diabetes Mellitus; Female; Hospital Mortality; Humans; Hypoxia; Male; Middle Aged; Organ Dysfunction Scores; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Respiratory Insufficiency; Risk FactorsFemaleRespiratory Insufficiencymortalidad hospitalariacomplicaciones de la diabetesHuman
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The impact of ten years of infant universal Varicella vaccination in Sicily, Italy (2003-2012).

2015

Introduction Universal varicella vaccination in Sicily was introduced in infant population since 2003, with a rapidly increasing coverage. Aim of the present study was to analyze changes in the epidemiology of varicella since the introduction of universal vaccination. Methods The study was performed by analyzing Sicilian administrative/clinical data on varicella case notifications and hospitalizations from 2003 to 2012 (ICD-9-CM discharge diagnosis codes 052 and 052.×). MMR+V and V coverage were also calculated for each birth cohort. Moreover, blood samples drawn in 2013/2014 from general population stratified by age were tested for varicella antibodies. Results From 2003 to 2012, 15 433 va…

AdultMalePediatricsmedicine.medical_specialtyAdolescentImmunologyPopulationSocio-culturalecoverageVaricella vaccinationAntibodies ViralSettore MED/42 - Igiene Generale E ApplicataChickenpox VaccineYoung AdultChickenpoxvaricellaEpidemiologyHumansImmunology and AllergyMedicineYoung adultChildeducationDisease NotificationSicilyChickenpox VaccineHospitalizationsPharmacologyeducation.field_of_studyChickenpoxbusiness.industryVaccinationInfant NewbornInfantNotificationsmedicine.diseaseHospitalizationVaccinationCoverage; Epidemiology; Hospitalizations; Notifications; Sicily; Universal mass vaccination; VaricellaChild PreschoolFemaleepidemiologynotificationbusinessBirth cohortuniversal mass vaccinationHumanResearch Paperhospitalization
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Role of clinical and laboratory parameters for treatment choice in patients with inherited FVII deficiency undergoing surgical procedures: evidence f…

2018

Perioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII-deficient patients undergoing 110 surgical procedures (61 major, 49 minor), we assessed the impact of type of surgery, bleeding phenotype and FVII coagulant activity (FVII:C) levels on perioperative replacement therapy (RT). Compared to those with higher FVII:C levels, patients with <3% FVII:C received a higher number of RT doses (8 vs. 2, P = 0·003) for a longer RT duration (3 days vs. 1 day, P = 0·001), with no difference in RT dose. Similarly, patients with a history of major bleeds received a higher number of RT doses (8·5 vs. 2-3, P = 0·013) for a longer RT duration (2…

AdultMalemedicine.medical_specialtyAdolescentClinical Decision-MakingSocio-culturaleHemorrhage030204 cardiovascular system & hematologyIndependent predictorGastroenterologyAsymptomaticsurgery03 medical and health scienceschemistry.chemical_compoundYoung Adult0302 clinical medicineInternal medicinemedicineHumansIn patientRegistriesFactor VII deficiencybleeding disordersbleeding disorderSurgical ProceduresFactor VIIbusiness.industryDisease ManagementPerioperativeHematologySurgical proceduresFactor VIIMiddle AgedCombined Modality TherapyOperativefactor VII deficiencyTreatment Outcomechemistry030220 oncology & carcinogenesisSurgical Procedures Operativebleeding disorders; factor VII deficiency; surgery; Adolescent; Adult; Clinical Decision-Making; Combined Modality Therapy; Disease Management; Factor VII; Factor VII Deficiency; Female; Hemorrhage; Humans; Male; Middle Aged; Registries; Surgical Procedures Operative; Symptom Assessment; Treatment Outcome; Young Adult; HematologyFemalemedicine.symptomSymptom AssessmentbusinessMajor bleeding
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Influenza vaccination coverage among medical residents: An Italian multicenter survey

2014

Although influenza vaccination is recognized to be safe and effective, recent studies have confirmed that immunization coverage among health care workers remain generally low, especially among medical residents (MRs). Aim of the present multicenter study was to investigate attitudes and determinants associated with acceptance of influenza vaccination among Italian MRs. A survey was performed in 2012 on MRs attending post-graduate schools of 18 Italian Universities. Each participant was interviewed via an anonymous, self-administered, web-based questionnaire including questions on attitudes regarding influenza vaccination. A total of 2506 MRs were recruited in the survey and 299 (11.9%) of t…

AdultMalemedicine.medical_specialtyPediatricsAttitude of Health PersonnelImmunologySocio-culturaleSettore MED/42 - Igiene Generale E ApplicataInfluenza immunizationmedical residentsPhysiciansHealth careInfluenza Humanmedicineinfluenza vaccination; coverage rateImmunology and AllergyHumansGood practiceCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Adult; Female; Humans; Influenza Vaccines; Influenza Human; Italy; Male; Vaccination; Attitude of Health Personnel; Data Collection; Internship and Residency; Physiciansmulticentre surveyEthical responsibilityPharmacologyCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre surveybusiness.industryinfluenza vaccination; medical residents; multicentre survey; coverage rate; ItalyData CollectionVaccinationInternship and ResidencyItaly coverage rate influenza vaccination medical residents multicentre surveyInfluenzainfluenza vaccinationVaccinationMulticenter studyItalyInfluenza VaccinesVaccination coverageFamily medicineCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Immunology and Allergy; Immunology; PharmacologyMulticenter surveyFemalebusinesscoverage rateResearch PaperHuman
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Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholeste…

2017

Homozygous familial hypercholesterolemia is a genetic disorder characterized by low-density lipoprotein (LDL)-receptor dysfunction, markedly elevated levels of LDL-cholesterol (LDL-C) and premature atherosclerosis. Patients are often poorly responsive to conventional lipid-lowering therapies that upregulate LDL-receptor expression.1 Lomitapide inhibits microsomal triglyceride transfer protein, which lipidates nascent apolipoprotein (apo)B-containing lipoproteins. In a pivotal 78-week open-label trial, lomitapide, titrated to the maximal tolerable dose, decreased LDL-C by 50% at the end of the efficacy phase (week 26) in patients with homozygous familial hypercholesterolemia.2 The principal …

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaApolipoprotein BSocio-culturaleFamilial hypercholesterolemia030204 cardiovascular system & hematologyGastroenterologyMicrosomal triglyceride transfer proteinLDLTimeSudden cardiac deathHyperlipoproteinemia Type II03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePhysiology (medical)Internal medicinemedicineHumans030212 general & internal medicineAdverse effectlomitapidebiologybusiness.industryCholesterolAnticholesteremic AgentsCholesterol LDLlomitapide; Adult; Anticholesteremic Agents; Benzimidazoles; Carrier Proteins; Cholesterol LDL; Female; Humans; Hyperlipoproteinemia Type II; Male; Timemedicine.diseaseLomitapideCholesterolEndocrinologychemistrybiology.proteinBenzimidazolesFemalelipids (amino acids peptides and proteins)lomitapide; Cardiology and Cardiovascular Medicine; Physiology (medical)Carrier ProteinsCardiology and Cardiovascular MedicinebusinessLipoproteinCirculation
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Five-year retrospective italian multicenter study of visceral leishmaniasis treatment.

2014

ABSTRACT The treatment of visceral leishmaniasis (VL) is poorly standardized in Italy in spite of the existing evidence. All consecutive patients with VL admitted at 15 Italian centers as inpatients or outpatients between January 2004 and December 2008 were retrospectively considered; outcome data at 1 year after treatment were obtained for all but 1 patient. Demographic characteristics, underlying diseases, diagnostic procedures, treatment regimens and outcomes, as well as side effects were recorded. A confirmed diagnosis of VL was reported for 166 patients: 120 (72.3%) immunocompetent, 21 (12.6%) patients with immune deficiencies other than HIV infection, and 25 (15.1%) coinfected with HI…

AdultMalemedicine.medical_specialtySettore MED/17 - Malattie InfettiveAdolescentAntiprotozoal AgentsSocio-culturaleClinical TherapeuticsAdolescent; Adult; Aged; Amphotericin B; Antiprotozoal Agents; Child; Female; Humans; Italy; Leishmaniasis Visceral; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult; Pharmacology (medical); Pharmacology; Infectious DiseasesYoung AdultAmphotericin BInternal medicineAmphotericin BmedicineHumansPharmacology (medical)Young adultvisceral leishmaniasis treatment ItalyChildLeishmaniasisAgedRetrospective StudiesVisceralPharmacologybusiness.industryAmbientaleRetrospective cohort studyMiddle Agedmedicine.diseaseSurgeryInfectious DiseasesVisceral leishmaniasisTreatment OutcomeMulticenter studyItalyLeishmaniasis VisceralLiposomal amphotericinFemaleOutcome databusinessAfter treatmentmedicine.drug
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The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CO…

2021

Abstract Background Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of th…

AdultPediatricsmedicine.medical_specialtyCancer Researchepidemiological studypopulation-based cancer registriesDatabases FactualPopulationepidemiological study; health care disparities; histology; International Classification of Diseases; population-based cancer registries; primary brain tumorSocio-culturalehealth care disparitiesCancer registration610 Medicine & healthAstrocytomahistology03 medical and health sciencesGlobal population0302 clinical medicineInternational Classification of Diseasesepidemiological study health care disparities histology International Classification of Diseases population-based cancer registries primary brain tumormedicineHumans1306 Cancer ResearchRegistrieseducationChildMedulloblastomaprimary brain tumoreducation.field_of_studybusiness.industryBrain NeoplasmsAstrocytomaCancerHistology10060 Epidemiology Biostatistics and Prevention Institute (EBPI)medicine.diseaseEurope2728 Neurology (clinical)Oncology030220 oncology & carcinogenesisPopulation study2730 OncologyNeurology (clinical)business030217 neurology & neurosurgery
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Impact of a new carrageenan-based vaginal microbicide in a female population with genital HPV-infection: First experimental results

2019

OBJECTIVE: The objective of this study was to assess safety, satisfaction, and anti- viral effect of a new carrageenan-based vaginal microbicide in a population of fertile female patients with genital human papillomavirus (HPV) infection. PATIENTS AND METHODS: Forty healthy and sexually active women aged 18-45 years with genital HPV infection were enrolled. Each subject was treated with a gel formulated with 0.02% carrageenan and Propionibacterium extract (CGP) (Carvir, Depofarma SpA, Mogliano Veneto, Treviso, Italy). The subjects were evaluated at baseline, after the I cycle of therapy and after the II cycle. At final status, treatment acceptability and satisfaction were evaluated using a …

AdultSettore MED/07 - Microbiologia E Microbiologia ClinicaHPVAdolescentSocio-culturaleMicrobicideCarrageenanCarrageenan Papillomavirus Microbicide Female population HPV.Young AdultAnti-Infective AgentsChondrusHumansProspective StudiesCarrageenan Papillomavirus Microbicide Female population HPVPapillomaviridaeFemale populationPapillomavirus InfectionsMiddle AgedPapillomavirusSeaweedAdministration IntravaginalTreatment OutcomeColposcopyPatient SatisfactionCase-Control StudiesDNA ViralVaginaVaginal Creams Foams and JelliesFemaleFollow-Up Studies
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Transitional care of young people with juvenile idiopathic arthritis in Italy: results of a Delphi consensus survey

2018

OBJECTIVES: To present the results of a Delphi consensus survey among Italian paediatric and adult rheumatologists on transitional care (TC) of young people (YP) with juvenile idiopathic arthritis (JIA). METHODS: A taskforce of 27 paediatric and adult rheumatologists evaluated the applicability of the 2016 EULAR/PReS recommendations for TC to the Italian rheumatology practice and healthcare system and formulated additional country-specific statements aimed to increase their suitability. After a two-round discussion, applicability of EULAR/PReS recommendations and agreement with newly-proposed statements were voted on a 0-10 scale (where 0 = no applicability/agreement and 10 = total applicab…

AdultTransition to Adult CareSettore MED/16 - REUMATOLOGIApaediatric rheumatic diseasesConsensusAdolescentJuvenileSocio-culturaleAdolescent; Adult; Child; Consensus; Humans; Italy; Surveys and Questionnaires; Arthritis Juvenile; Rheumatology; Transition to Adult Care; Transitional Carejuvenile idiopathic arthritis paediatric rheumatic diseases Delphi survey recommendations transitional care young peopleAdolescent Adult Child Consensus Humans Italy Surveys and Questionnaires Arthritis Juvenile Rheumatology Transition to Adult Care Transitional Careyoung peopleSettore MED/38 - Pediatria Generale E Specialisticayoung peopleAdolescentRheumatologySurveys and QuestionnairesHumansChildLS7_9ArthritisTransitional CareArthritis JuvenileItalyrecommendationsjuvenile idiopathic arthritisDelphi surveyjuvenile idiopathic arthritis paediatric rheumatic diseases Delphi survey recommendations transitional care young people
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Italian cancer figures, report 2014: Prevalence and cure of cancer in Italy

2015

This Report intends to estimate the total number of people still alive in 2010 after cancer diagnosis in Italy, regardless of the time since diagnosis, and to project these estimates to 2015. This study is also aimed to estimate the number of already cured cancer patients, whose mortality rates have become undistinguishable from that of the general population of the same age and sex.The study took advantage of the information from the AIRTUM database, which included 29 Cancer Registries (covering 21 million people, 35% of the Italian population). A total of 1,624,533 cancer cases diagnosed between 1976 and 2009 contributed to the study. For each registry, the observed prevalence was calcula…

Aged 80 and overMaleMedicine (all)Aged; Aged 80 and over; Female; Humans; Italy; Male; Middle Aged; Neoplasms; Prevalence; Registries; Survival RateSocio-culturaleMiddle AgedSettore MED/42 - Igiene Generale E ApplicataSurvival RateItalyNeoplasms80 and overPrevalenceHumanscancer prevalence cancer incidence cancer in ItalyFemaleRegistriesAged
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